Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration

Gary White Sallisaw Equine Clinic, 213 Mockingbird Ln, Sallisaw, OK 74955

Search for other papers by Gary White in
Current site
Google Scholar
PubMed
Close
 DVM
,
Scott R. McClure Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250

Search for other papers by Scott R. McClure in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Roger Sifferman Bradford Park Veterinary Hospital, 1255 E Independence, Springfield, MO 65804

Search for other papers by Roger Sifferman in
Current site
Google Scholar
PubMed
Close
 DVM
,
John E. Holste B&P Consulting, 1105 Vegas Dr, Columbia, MO 65203

Search for other papers by John E. Holste in
Current site
Google Scholar
PubMed
Close
 DVM
,
Candis Fleishman Merial Limited, 3239 Satellite Blvd, Duluth, GA 30096

Search for other papers by Candis Fleishman in
Current site
Google Scholar
PubMed
Close
 M Stat
,
Michael J. Murray Merial Limited, 3239 Satellite Blvd, Duluth, GA 30096

Search for other papers by Michael J. Murray in
Current site
Google Scholar
PubMed
Close
 DVM, MS
, and
Luiz G. Cramer Merial Limited, 3239 Satellite Blvd, Duluth, GA 30096

Search for other papers by Luiz G. Cramer in
Current site
Google Scholar
PubMed
Close
 DVM
Restricted access
Purchase Article

Abstract

Objective—To determine the effects of 8 days of light to heavy exercise on gastric ulcer development in horses and determine the efficacy of omeprazole paste in preventing gastric ulceration.

Design—Randomized, controlled, multicenter clinical trial.

Animals—102 horses with normal-appearing gastric mucosa on endoscopic examination that were in light to heavy training.

Procedures—Horses at 4 trial locations were allocated into replicates and sham dosed orally (empty syringe) or treated with a paste formulation of omeprazole (1 mg/kg [0.45 mg/ lb], PO) once daily for 8 days. Training regimens varied among locations and included early training for western performance events; walking, trotting, and cantering in a mechanical exerciser; and race training (2 locations). Prevalences of gastric ulceration at the completion of the 8-day treatment period were compared between groups.

Results—At the end of the 8-day treatment period, the proportion of omeprazole-treated horses free from gastric ulceration (88%) was significantly higher than the proportion of sham-dosed horses free from gastric ulceration (27%).

Conclusions and Clinical Relevance—Results showed that horses in light to heavy training for as short as 8 days were at risk of developing gastric ulcers and that administration of omeprazole paste decreased the incidence of gastric ulcers.

All Time Past Year Past 30 Days
Abstract Views 243 0 0
Full Text Views 1736 796 45
PDF Downloads 494 173 10
Advertisement