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    Baggot SM. Veterinarians as advocates for animal rights. J Am Vet Med Assoc 2006;229:350352.

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Letter to the Editor

Questions value of vacuolar hepatopathy study

In the July 15, 2006, issue of the JAVMA, Sepesy et al1 provide empiric evidence that dogs with vacuolar hepatopathy (VH), referring to morphologic alterations in hepatocytes subjected to glucocorticoids, often have a variety of other disorders that do not include “overt” glucocorticoid drug exposure or hyperadrenocorticism (HAC). The clinical implication is that detection of glycogenosis and ballooning of hepatocytes (ie, VH) is not as specific for glucocorticosteroid exposure or HAC as generally perceived.

I contend that this retrospective evaluation does not contribute valid data to clarifying specificity of VH

Questions value of vacuolar hepatopathy study

In the July 15, 2006, issue of the JAVMA, Sepesy et al1 provide empiric evidence that dogs with vacuolar hepatopathy (VH), referring to morphologic alterations in hepatocytes subjected to glucocorticoids, often have a variety of other disorders that do not include “overt” glucocorticoid drug exposure or hyperadrenocorticism (HAC). The clinical implication is that detection of glycogenosis and ballooning of hepatocytes (ie, VH) is not as specific for glucocorticosteroid exposure or HAC as generally perceived.

I contend that this retrospective evaluation does not contribute valid data to clarifying specificity of VH