Objective—To compare long-term results of radiotherapy
alone versus radiotherapy followed by exenteration
of the nasal cavity in dogs with malignant
Animals—53 dogs with malignant intranasal neoplasia.
Procedure—All dogs underwent radiotherapy consisting
of administration of 10 fractions of 4.2 Gy each
on consecutive weekdays. For dogs in the surgery
group (n = 13), follow-up computed tomography was
performed, and dogs were scheduled for surgery if
persistent or recurrent tumor was seen.
Results—Perioperative complications for dogs that
underwent surgery included hemorrhage requiring
transfusion (2 dogs) and subcutaneous emphysema
(8). Rhinitis and osteomyelitis-osteonecrosis occurred
significantly more frequently in dogs in the radiotherapy
and surgery group (9 and 4 dogs, respectively)
than in dogs in the radiotherapy-only group (4 and 3
dogs, respectively). Two- and 3-year survival rates
were 44% and 24%, respectively, for dogs in the
radiotherapy group and 69% and 58%, respectively,
for dogs in the surgery group. Overall median survival
time for dogs in the radiotherapy and surgery group
(47.7 months) was significantly longer than time for
dogs in the radiotherapy-only group (19.7 months).
Conclusions and Clinical Relevance—Results suggest
that exenteration of the nasal cavity significantly
prolongs survival time in dogs with intranasal neoplasia
that have undergone radiotherapy. Exenteration after
radiotherapy may increase the risk of chronic complications.
(J Am Vet Med Assoc 2005;227:936–941)