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Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training

Scott R. McClure DVM, PhD, DACVS1, Gary W. White DVM2, Roger L. Sifferman DVM3, William Bernard DVM, MS, DACVIM4, Michèle Y. Doucet DMV, MSc, DVSc, DACVIM, DACVCP5, Andre Vrins DMV6, John E. Holste DVM7, Candis Fleishman MS8, Roberto Alva DVM, PhD9, and Luiz G. Cramer DVM10
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  • 1 College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250
  • | 2 Sallisaw Equine Clinic, 213 Mockingbird Ln, Sallisaw, OK 74955.
  • | 3 Bradford Park Veterinary Hospital, 1255 E Independence, Springfield, MO 65804.
  • | 4 Rood & Riddle Equine Hospital, 4901 Mt Horeb, Lexington, KY 40511.
  • | 5 Universite de Montreal, Montreal, QC, Canada.
  • | 6 Universite de Montreal, Montreal, QC, Canada.
  • | 7 Merial Ltd, Missouri Research Center, 6498 Jade Rd, Fulton, MO 65251.
  • | 8 Merial Ltd, 3239 Satellite Blvd, Duluth, GA 30096.
  • | 9 Merial Ltd, 3239 Satellite Blvd, Duluth, GA 30096.
  • | 10 Merial Ltd, 3239 Satellite Blvd, Duluth, GA 30096.

Abstract

Objective—To determine the minimal effective dosage of omeprazole oral paste for the prevention of naturally occurring ulcers in horses starting race training.

Design—Prospective study.

Animals—175 horses.

Procedure—Horses in the dose selection portion of the study were sham dose treated or received 1 mg (0.45 mg/lb) or 2 mg (0.9 mg/lb) of omeprazole/kg, PO, every 24 hours for 28 days or 4 mg of omeprazole/ kg (1.8 mg/lb; loading dose), PO, every 24 hours for 4 days, then 1 or 2 mg of omeprazole/kg, PO, every 24 hours for 24 days. Horses in the dose confirmation portion of the study were sham dose treated or received 1 mg of omeprazole/kg, PO, every 24 hours for 28 days. Gastric ulcer scores at the beginning and end of the study were compared.

Results—Sham–dose-treated horses had significantly higher ulcer scores than did horses treated with any of the omeprazole dosages evaluated. Among horses treated with omeprazole, there was no significant interaction of dose (1 or 2 mg/kg) and loading dose; therefore, the lowest effective dose (1 mg/kg) was evaluated in the dose confirmation portion of the study. In the dose confirmation study, 4 of 39 (10%) sham–dose-treated horses remained ulcer free, which was significantly different from the proportion of horses (31/38 [82%]) receiving 1 mg of omeprazole/ kg that remained ulcer free.

Conclusions and Clinical Relevance—Results indicated that omeprazole administered at a dosage of 1 mg/kg, PO, every 24 hours for 28 days was effective for prevention of gastric ulcers in horses starting race training. (J Am Vet Med Assoc 2005;226:1681–1684)

Abstract

Objective—To determine the minimal effective dosage of omeprazole oral paste for the prevention of naturally occurring ulcers in horses starting race training.

Design—Prospective study.

Animals—175 horses.

Procedure—Horses in the dose selection portion of the study were sham dose treated or received 1 mg (0.45 mg/lb) or 2 mg (0.9 mg/lb) of omeprazole/kg, PO, every 24 hours for 28 days or 4 mg of omeprazole/ kg (1.8 mg/lb; loading dose), PO, every 24 hours for 4 days, then 1 or 2 mg of omeprazole/kg, PO, every 24 hours for 24 days. Horses in the dose confirmation portion of the study were sham dose treated or received 1 mg of omeprazole/kg, PO, every 24 hours for 28 days. Gastric ulcer scores at the beginning and end of the study were compared.

Results—Sham–dose-treated horses had significantly higher ulcer scores than did horses treated with any of the omeprazole dosages evaluated. Among horses treated with omeprazole, there was no significant interaction of dose (1 or 2 mg/kg) and loading dose; therefore, the lowest effective dose (1 mg/kg) was evaluated in the dose confirmation portion of the study. In the dose confirmation study, 4 of 39 (10%) sham–dose-treated horses remained ulcer free, which was significantly different from the proportion of horses (31/38 [82%]) receiving 1 mg of omeprazole/ kg that remained ulcer free.

Conclusions and Clinical Relevance—Results indicated that omeprazole administered at a dosage of 1 mg/kg, PO, every 24 hours for 28 days was effective for prevention of gastric ulcers in horses starting race training. (J Am Vet Med Assoc 2005;226:1681–1684)