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Use of low molecular weight heparin in cats: 57 cases (1999–2003)

Caren E. SmithDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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Elizabeth A. RozanskiDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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 DVM, DACVIM, DACVECC
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Lisa M. FreemanDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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Donald J. BrownDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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Jennifer S. GoodmanDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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John E. RushDepartment of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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 DVM, MS, DACVIM, DACVECC

Abstract

Objective—To determine duration of administration, complications, and frequency of aortic thromboembolism associated with administration of low molecular weight heparin (dalteparin) in cats.

Design—Retrospective study.

Animals—57 cats treated with dalteparin.

Procedure—Data were recorded from the medical records of cats treated with dalteparin, and owners were contacted by telephone for information regarding ease of administration and possible adverse effects.

Results—Dalteparin was easily administered by owners. Median dose was 99 U/kg (45 U/lb) once or twice daily. Bleeding complications were infrequent. Of 43 cats with cardiomyopathy that received owner-administered dalteparin for a median follow-up time of 172 days, 8 cats developed documented or possible arterial thromboembolism.

Conclusions and Clinical Relevance—Dalteparin was easily administered by owners and was well tolerated by cats. Whether dalteparin administration can reduce the frequency or severity of arterial thromboembolism is not yet known. (J Am Vet Med Assoc 2004;225:1237–1241)

Abstract

Objective—To determine duration of administration, complications, and frequency of aortic thromboembolism associated with administration of low molecular weight heparin (dalteparin) in cats.

Design—Retrospective study.

Animals—57 cats treated with dalteparin.

Procedure—Data were recorded from the medical records of cats treated with dalteparin, and owners were contacted by telephone for information regarding ease of administration and possible adverse effects.

Results—Dalteparin was easily administered by owners. Median dose was 99 U/kg (45 U/lb) once or twice daily. Bleeding complications were infrequent. Of 43 cats with cardiomyopathy that received owner-administered dalteparin for a median follow-up time of 172 days, 8 cats developed documented or possible arterial thromboembolism.

Conclusions and Clinical Relevance—Dalteparin was easily administered by owners and was well tolerated by cats. Whether dalteparin administration can reduce the frequency or severity of arterial thromboembolism is not yet known. (J Am Vet Med Assoc 2004;225:1237–1241)