Advertisement

Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats

Charlotte H. EdinboroDepartments of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Present address is Exponent Inc, Health Practice, 149 Commonwealth Dr, Menlo Park, CA 94025.

Search for other papers by Charlotte H. Edinboro in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
J. Catharine Scott-MoncrieffDepartment of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by J. Catharine Scott-Moncrieff in
Current site
Google Scholar
PubMed
Close
 VetMB, MS, DACVIM
,
Evan JanovitzDepartments of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Present address is Discovery Toxicology, Pharmaceutical Research Institute, Bristol-Myers Squibb Co, PO Box 5400, Princeton, NJ 08543.

Search for other papers by Evan Janovitz in
Current site
Google Scholar
PubMed
Close
 DVM, PhD, DACVP
,
H. Leon ThackerDepartments of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by H. Leon Thacker in
Current site
Google Scholar
PubMed
Close
 DVM, PhD, DACVP
, and
Larry T. GlickmanDepartments of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by Larry T. Glickman in
Current site
Google Scholar
PubMed
Close
 VMD, DrPH

Abstract

Objective—To determine whether the increasing prevalence of feline hyperthyroidism is the result of aging of the cat population and whether consumption of canned foods at various times throughout life is associated with increased risk of hyperthyroidism.

Design—Retrospective and case-control studies.

Study Population—Medical records of 169,576 cats, including 3,570 cats with hyperthyroidism, evaluated at 9 veterinary school hospitals during a 20-year period, and 109 cats with hyperthyroidism (cases) and 173 cats without hyperthyroidism (controls).

Procedure—Age-adjusted hospital prevalence of hyperthyroidism was calculated by use of Veterinary Medical Database records. On the basis of owners' questionnaire responses, logistic regression was used to evaluate associations between consumption of canned food and development of hyperthyroidism.

Results—Age-specific hospital prevalence of feline hyperthyroidism increased significantly from 1978 to 1997. Overall, consumption of pop-top canned (vs dry) food at various times throughout life and each additional year of age were associated with greater risk of developing hyperthyroidism. In female cats, increased risk was associated with consumption of food packaged in pop-top cans or in combinations of pop-top and non-pop-top cans. In male cats, increased risk was associated with consumption of food packaged in pop-top cans and age.

Conclusions and Clinical Relevance—These findings suggest that the increasing prevalence of feline hyperthyroidism is not solely the result of aging of the cat population and that canned foods may play a role. (J Am Vet Med Assoc 2004;224:879–886)

Abstract

Objective—To determine whether the increasing prevalence of feline hyperthyroidism is the result of aging of the cat population and whether consumption of canned foods at various times throughout life is associated with increased risk of hyperthyroidism.

Design—Retrospective and case-control studies.

Study Population—Medical records of 169,576 cats, including 3,570 cats with hyperthyroidism, evaluated at 9 veterinary school hospitals during a 20-year period, and 109 cats with hyperthyroidism (cases) and 173 cats without hyperthyroidism (controls).

Procedure—Age-adjusted hospital prevalence of hyperthyroidism was calculated by use of Veterinary Medical Database records. On the basis of owners' questionnaire responses, logistic regression was used to evaluate associations between consumption of canned food and development of hyperthyroidism.

Results—Age-specific hospital prevalence of feline hyperthyroidism increased significantly from 1978 to 1997. Overall, consumption of pop-top canned (vs dry) food at various times throughout life and each additional year of age were associated with greater risk of developing hyperthyroidism. In female cats, increased risk was associated with consumption of food packaged in pop-top cans or in combinations of pop-top and non-pop-top cans. In male cats, increased risk was associated with consumption of food packaged in pop-top cans and age.

Conclusions and Clinical Relevance—These findings suggest that the increasing prevalence of feline hyperthyroidism is not solely the result of aging of the cat population and that canned foods may play a role. (J Am Vet Med Assoc 2004;224:879–886)