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Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows

John R. ChenaultPfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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Joseph F. McAllisterPfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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S. Theodore Chester JrPfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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Kenneth J. DamePfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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Fabian M. KauschePfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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Edward J. RobbPfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001.

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Abstract

Objective—To evaluate the efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for treatment of acute postpartum metritis (APM) in dairy cows.

Design—Multilocation, randomized block, field trial.

Animals—406 cows in the first 14 days postpartum.

Procedure—Cows with rectal temperatures ≥ 39.5°C (103.1°F) without clinical signs of respiratory or gastrointestinal tract disease and with a fetid vaginal discharge were allocated randomly in blocks of 3 to 3 treatment groups: sterile saline (0.9% NaCl) solution administered at a dosage of 2 mL/45.4 kg (2 mL/100 lb), SC or IM, once daily for 5 days (control); or ceftiofur hydrochloride administered at a dosage of 1.1 or 2.2 mg of ceftiofur equivalents (CE)/kg (0.5 or 1 mg/lb, respectively), SC or IM, once daily for 5 days. Cows were evaluated on days 6, 10, and 14, and clinical cure or failure to cure was determined. Clinical cure was defined as no additional antimicrobial treatment administered, rectal temperature < 39.5°C, and absence of a fetid vaginal discharge.

Results—On day 14, clinical cure rates were 77%, 65%, and 62% for the 2.2 mg of CE/kg, 1.1 mg of CE/kg, and control groups, respectively. No significant differences were detected in clinical cure rates between control and treatment groups on day 10 or 6.

Conclusions and Clinical Relevance—Ceftiofur hydrochloride administered at a dosage of 2.2 mg of CE/kg, SC or IM, once daily for 5 days was efficacious for treatment of APM in dairy cows. (J Am Vet Med Assoc 2004;224:1634–1639)

Abstract

Objective—To evaluate the efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for treatment of acute postpartum metritis (APM) in dairy cows.

Design—Multilocation, randomized block, field trial.

Animals—406 cows in the first 14 days postpartum.

Procedure—Cows with rectal temperatures ≥ 39.5°C (103.1°F) without clinical signs of respiratory or gastrointestinal tract disease and with a fetid vaginal discharge were allocated randomly in blocks of 3 to 3 treatment groups: sterile saline (0.9% NaCl) solution administered at a dosage of 2 mL/45.4 kg (2 mL/100 lb), SC or IM, once daily for 5 days (control); or ceftiofur hydrochloride administered at a dosage of 1.1 or 2.2 mg of ceftiofur equivalents (CE)/kg (0.5 or 1 mg/lb, respectively), SC or IM, once daily for 5 days. Cows were evaluated on days 6, 10, and 14, and clinical cure or failure to cure was determined. Clinical cure was defined as no additional antimicrobial treatment administered, rectal temperature < 39.5°C, and absence of a fetid vaginal discharge.

Results—On day 14, clinical cure rates were 77%, 65%, and 62% for the 2.2 mg of CE/kg, 1.1 mg of CE/kg, and control groups, respectively. No significant differences were detected in clinical cure rates between control and treatment groups on day 10 or 6.

Conclusions and Clinical Relevance—Ceftiofur hydrochloride administered at a dosage of 2.2 mg of CE/kg, SC or IM, once daily for 5 days was efficacious for treatment of APM in dairy cows. (J Am Vet Med Assoc 2004;224:1634–1639)