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Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation

Clarke E. AtkinsDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.

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William A. BrownVeterinary Cardiology Consults, 1886 Birmingham Blvd, Birmingham, MI 48009.

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Julie R. CoatsDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.

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Mary Ann CrawfordOradell Animal Hospital, 481 Kinderkamack Rd, Oradell, NJ 07649.

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Teresa C. DeFrancescoDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.

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Joel EdwardsAlbany County Veterinary Hospital, 148 Bozekill Rd, Albany, NY 12203.

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Philip R. FoxThe Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Bruce W. KeeneDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.

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Linda LehmkuhlDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Present address is MedVet Specialty Clinic, 5747 Cleveland Ave, Columbus, OH 43231.

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Michael LuethyCardioscope Pet Referral Service, 1820 Frontage Rd, Northbrook, IL 60062.

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Kate MeursThe Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

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Jean-Paul PetrieThe Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Frank PipersMerial Inc, 3239 Satellite Blvd, Duluth, GA 30096.
Present address is Dove Lewis Emergency Animal Hospital, 1984 NW Pettygrove Ave, Portland, OR 97209.

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Steven RosenthalChesapeake Veterinary Referral Center, 808 Bathgate Rd, Annapolis, MD 21401.

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Jennifer A. SidleyDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.
Present address is Chesapeake Veterinary Referral Center, 808 Bathgate Rd, Annapolis, MD 21401.

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Justin StrausOradell Animal Hospital, 481 Kinderkamack Rd, Oradell, NJ 07649.
Present address is Animal Emergency and Referral Center, 647 Bloomfield Ave, West Caldwell, NJ 07006.

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Abstract

Objective—To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.

Design—Randomized controlled trial.

Animals—139 dogs with mitral regurgitation but without overt signs of heart failure.

Procedure—Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months.

Results—Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a ≥ 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups.

Conclusions and Clinical Relevance—Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation. (J Am Vet Med Assoc 2002;221: 654–658)

Abstract

Objective—To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.

Design—Randomized controlled trial.

Animals—139 dogs with mitral regurgitation but without overt signs of heart failure.

Procedure—Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months.

Results—Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a ≥ 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups.

Conclusions and Clinical Relevance—Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation. (J Am Vet Med Assoc 2002;221: 654–658)