Advertisement

Evaluation of sedative and cardiorespiratory effects of romifidine and romifidine-butorphanol in cats

André L. SelmiVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by André L. Selmi in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Glenda R. Barbudo-SelmiVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Glenda R. Barbudo-Selmi in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Carla F. MoreiraVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Carla F. Moreira in
Current site
Google Scholar
PubMed
Close
 DVM
,
Christine S. MartinsVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Christine S. Martins in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Bruno T. LinsVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Bruno T. Lins in
Current site
Google Scholar
PubMed
Close
 DVM
,
Guilherme M. MendesVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Guilherme M. Mendes in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Concepta McManusVeterinary Teaching Hospital, Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF 70910-970, Brazil.

Search for other papers by Concepta McManus in
Current site
Google Scholar
PubMed
Close
 PhD

Abstract

Objective—To determine sedative and cardiorespiratory effects of romifidine alone and romifidine in combination with butorphanol and effects of preemptive atropine administration in cats sedated with romifidine-butorphanol.

Design—Randomized crossover study.

Animals—6 healthy adult cats.

Procedures—Cats were given saline (0.9% NaCl) solution followed by romifidine alone (100 µg/kg [45.4 µg/lb], IM), saline solution followed by a combination of romifidine (40 µg/kg [18.1 µg/lb], IM) and butorphanol (0.2 mg/kg [0.09 mg/lb], IM), or atropine (0.04 mg/kg [0.02 mg/lb], SC) followed by romifidine (40 µg/kg, IM) and butorphanol (0.2 mg/kg, IM). Treatments were administered in random order, with ≥ 1 week between treatments. Physiologic variables were determined before and after drug administration. Time to recumbency, duration of recumbency, time to recover from sedation, and subjective evaluation of sedation, muscle relaxation, and analgesia were assessed.

Results—Bradycardia developed in all cats that received saline solution and romifidine-butorphanol or romifidine alone. Preemptive administration of atropine prevented bradycardia for 50 minutes in cats given romifidine-butorphanol. Oxyhemoglobin saturation was significantly decreased 10 minutes after romifidine-butorphanol administration in atropinetreated cats.

Conclusions and Clinical Relevance—Results suggested that administration of romifidine alone or romifidine-butorphanol causes a significant decrease in heart rate and that preemptive administration of atropine in cats sedated with romifidine-butorphanol effectively prevents bradycardia for 50 minutes. (J Am Vet Med Assoc 2002;221: 506–510)

Abstract

Objective—To determine sedative and cardiorespiratory effects of romifidine alone and romifidine in combination with butorphanol and effects of preemptive atropine administration in cats sedated with romifidine-butorphanol.

Design—Randomized crossover study.

Animals—6 healthy adult cats.

Procedures—Cats were given saline (0.9% NaCl) solution followed by romifidine alone (100 µg/kg [45.4 µg/lb], IM), saline solution followed by a combination of romifidine (40 µg/kg [18.1 µg/lb], IM) and butorphanol (0.2 mg/kg [0.09 mg/lb], IM), or atropine (0.04 mg/kg [0.02 mg/lb], SC) followed by romifidine (40 µg/kg, IM) and butorphanol (0.2 mg/kg, IM). Treatments were administered in random order, with ≥ 1 week between treatments. Physiologic variables were determined before and after drug administration. Time to recumbency, duration of recumbency, time to recover from sedation, and subjective evaluation of sedation, muscle relaxation, and analgesia were assessed.

Results—Bradycardia developed in all cats that received saline solution and romifidine-butorphanol or romifidine alone. Preemptive administration of atropine prevented bradycardia for 50 minutes in cats given romifidine-butorphanol. Oxyhemoglobin saturation was significantly decreased 10 minutes after romifidine-butorphanol administration in atropinetreated cats.

Conclusions and Clinical Relevance—Results suggested that administration of romifidine alone or romifidine-butorphanol causes a significant decrease in heart rate and that preemptive administration of atropine in cats sedated with romifidine-butorphanol effectively prevents bradycardia for 50 minutes. (J Am Vet Med Assoc 2002;221: 506–510)