Objective—To determine the association between
cancer chemotherapy and serum canine distemper
virus (CDV), canine parvovirus (CPV), and rabies virus
antibody titers in tumor-bearing dogs.
Animals—21 client-owned dogs with various malignancies
and 16 client-owned dogs with lymphoma.
Procedure—In study A, serum antibody titers were
measured by use of hemagglutination inhibition (CPV
titers) or serum neutralization (CDV titers) before and
at least 1 month after initiation of chemotherapy.
Baseline values were compared with values obtained
from a control population of 122 healthy dogs seen for
routine revaccination. Titers were considered protective
at ≥ 1:96 for CDV and ≥ 1:80 for CPV.
In study B, serum IgG titers were measured by
use of immunofluorescent assay (CDV and CPV titers)
and rapid fluorescent focus inhibition test (RFFIT,
rabies titers) at baseline and again at weeks 5, 8, and
24 of a standard chemotherapy protocol for treatment
of lymphoma. An IgG titer of ≥ 1:50 was considered
protective for CPV and CDV. An RFFIT titer of ≥ 0.5
U/ml was considered protective for rabies virus.
Results—Significant changes were not detected in
CDV, CPV, and rabies virus titers following chemotherapy
in tumor-bearing dogs.
Conclusions and Clinical Relevance—Results suggest
that established immunity to CDV, CPV, and
rabies virus from previous vaccination is not significantly
compromised by standard chemotherapy used
to treat tumor-bearing dogs. (J Am Vet Med Assoc