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Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy

Kaitkanoke Sirinarumitr DVM, PhD1,2, Shirley D. Johnston DVM, PhD, DACT3, Margaret V. Root Kustritz DVM, PhD, DACT4, Gary R. Johnston DVM, MS, DACVR5, Dipak K. Sarkar PhD6, and Mushtaq A. Memon BVSc, PhD, DACT7
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  • 1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164.
  • | 2 Present address is Department of Obstetrics, Gynaecology, and Animal Reproduction, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10903, Thailand.
  • | 3 College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766-1854.
  • | 4 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.
  • | 5 College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766-1854.
  • | 6 Department of Veterinary Comparative Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164.
  • | 7 Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

Abstract

Objective—To determine the effect of the 5α-reductase inhibitor finasteride on prostatic diameter and volume, semen quality, and serum dihydrotestosterone (DHT) and testosterone concentrations in dogs with spontaneous benign prostatic hypertrophy (BPH).

Design—Double-blind placebo-controlled trial.

Animals—9 dogs with BPH.

Procedure—Five dogs were treated with finasteride for 16 weeks (0.1 to 0.5 mg/kg [0.05 to 0.23 mg/lb] of body weight, PO, q 24 h); the other 4 received a placebo. Prostatic diameter, measured radiographically, prostatic volume, measured ultrasonographically, semen quality, and serum DHT and testosterone concentrations were evaluated before and during treatment. After receiving the placebo for 16 weeks, the 4 control dogs were treated with finasteride for 16 weeks, and evaluations were repeated.

Results—Finasteride significantly decreased prostatic diameter (mean percentage decrease, 20%), prostatic volume (mean percentage decrease, 43%), and serum DHT concentration (mean percentage decrease, 58%). Finasteride decreased semen volume but did not adversely effect semen quality or serum testosterone concentration. No adverse effects were reported by owners of dogs in the study.

Conclusions and Clinical Relevance—Results suggest that finasteride can be used to reduce prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration. (J Am Vet Med Assoc 2001;218:1275–1280)

Abstract

Objective—To determine the effect of the 5α-reductase inhibitor finasteride on prostatic diameter and volume, semen quality, and serum dihydrotestosterone (DHT) and testosterone concentrations in dogs with spontaneous benign prostatic hypertrophy (BPH).

Design—Double-blind placebo-controlled trial.

Animals—9 dogs with BPH.

Procedure—Five dogs were treated with finasteride for 16 weeks (0.1 to 0.5 mg/kg [0.05 to 0.23 mg/lb] of body weight, PO, q 24 h); the other 4 received a placebo. Prostatic diameter, measured radiographically, prostatic volume, measured ultrasonographically, semen quality, and serum DHT and testosterone concentrations were evaluated before and during treatment. After receiving the placebo for 16 weeks, the 4 control dogs were treated with finasteride for 16 weeks, and evaluations were repeated.

Results—Finasteride significantly decreased prostatic diameter (mean percentage decrease, 20%), prostatic volume (mean percentage decrease, 43%), and serum DHT concentration (mean percentage decrease, 58%). Finasteride decreased semen volume but did not adversely effect semen quality or serum testosterone concentration. No adverse effects were reported by owners of dogs in the study.

Conclusions and Clinical Relevance—Results suggest that finasteride can be used to reduce prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration. (J Am Vet Med Assoc 2001;218:1275–1280)