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Effect of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus

Richard W. Nelson DVM, DACVIM1, J. Catharine Scott-Moncrieff MS, VetMB, DACVIM2, Edward C. Feldman DVM, DACVIM3, Susan E. DeVries-Concannon DVM, DACVIM4,5, Philip H. Kass DVM, PhD6, Deborah J. Davenport DVM, MS, DACVIM7, Christine T. Kiernan BS8, and Larry A. Neal BS9
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  • 1 Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 2 Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1248.
  • | 3 Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 4 Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 5 Present address is Glaxo Wellcome Inc, 3030 Cornwallis Rd, Research Triangle Park, NC 27709.
  • | 6 Departments of Population, Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 7 Mark Morris Associates, PO Box 1658, Topeka, KS 66601.
  • | 8 Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 9 Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.

Abstract

Objective—To evaluate effects of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus.

Design—Randomized controlled crossover trial.

Animals—16 cats with naturally acquired diabetes mellitus.

Procedure—Cats were fed a diet high in insoluble fiber (HF) containing 12% cellulose (dry-matter basis) or a diet low in insoluble fiber (LF) for 24 weeks; they were fed the other diet for the subsequent 24 weeks. Caloric intake and insulin treatment were adjusted to maintain stable body weight and control of glycemia, respectively. Cats were allowed an adaption period of 6 weeks after initiation of a diet, after which control of glycemia was evaluated at 6-week intervals for 18 weeks. Variables assessed included serum glucose concentration measured during the preprandial state, blood glycated hemoglobin concentration, serum glucose concentration measured at 2-hour intervals for 12 hours beginning at the time of the morning insulin injection, 12-hour mean serum glucose concentration, and mean fluctuation in serum glucose concentration from the 12-hour mean serum glucose concentration.

Results—Mean daily caloric intake, body weight, or daily insulin dosage did not differ significantly between cats when fed HF and LF diets. Mean preprandial serum glucose concentration, most postprandial serum glucose concentrations, and the 12-hour mean serum glucose concentration were significantly lower when cats consumed the HF diet, compared with values when cats consumed the LF diet.

Conclusions and Clinical Relevance—These results support feeding a commercially available diet containing approximately 12% insoluble fiber (dry-matter basis) to cats with naturally acquired diabetes mellitus. (J Am Vet Med Assoc 2000;216:1082–1088)

Abstract

Objective—To evaluate effects of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus.

Design—Randomized controlled crossover trial.

Animals—16 cats with naturally acquired diabetes mellitus.

Procedure—Cats were fed a diet high in insoluble fiber (HF) containing 12% cellulose (dry-matter basis) or a diet low in insoluble fiber (LF) for 24 weeks; they were fed the other diet for the subsequent 24 weeks. Caloric intake and insulin treatment were adjusted to maintain stable body weight and control of glycemia, respectively. Cats were allowed an adaption period of 6 weeks after initiation of a diet, after which control of glycemia was evaluated at 6-week intervals for 18 weeks. Variables assessed included serum glucose concentration measured during the preprandial state, blood glycated hemoglobin concentration, serum glucose concentration measured at 2-hour intervals for 12 hours beginning at the time of the morning insulin injection, 12-hour mean serum glucose concentration, and mean fluctuation in serum glucose concentration from the 12-hour mean serum glucose concentration.

Results—Mean daily caloric intake, body weight, or daily insulin dosage did not differ significantly between cats when fed HF and LF diets. Mean preprandial serum glucose concentration, most postprandial serum glucose concentrations, and the 12-hour mean serum glucose concentration were significantly lower when cats consumed the HF diet, compared with values when cats consumed the LF diet.

Conclusions and Clinical Relevance—These results support feeding a commercially available diet containing approximately 12% insoluble fiber (dry-matter basis) to cats with naturally acquired diabetes mellitus. (J Am Vet Med Assoc 2000;216:1082–1088)