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Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis

John A. Angelos MS, DVM, DACVIM1, Erica L. Dueger DVM, DACVIM2, Lisle W. George DVM, PhD, DACVIM3, Tracey K. Carrier DVM, MPVM4,5, Judy E. Mihalyi BS6, Sallie B. Cosgrove MS, DVM7, and John C. Johnson DVM, MS8
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  • 1 Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 2 Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 3 Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 4 Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 5 Present address: Third Avenue Animal Medical Center, 1280 3rd Ave, Chula Vista, CA 91911.
  • | 6 Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • | 7 Schering-Plough Animal Health Corp, 1095 Morris Ave, Union, NJ 07083.
  • | 8 Schering-Plough Animal Health Corp, PO Box 3113, Omaha, NE 68103.

Abstract

Objective—To determine the efficacy of florfenicol for treatment of calves with naturally occurring infectious bovine keratoconjunctivitis (IBK).

Design—Randomized controlled field trial.

Animals—63 beef calves and 80 dairy calves between 4 and 12 months of age.

Procedure—Calves were randomly assigned to 1 of 3 treatment groups. Calves in the SC treatment group received a single dose of florfenicol (40 mg/kg [18.2 mg/lb] of body weight), SC, on day 0. Calves in the IM treatment group received florfenicol (20 mg/kg [9.1 mg/lb]), IM, on days 0 and 2. Calves in the control group received injections of saline solution (0.9% NaCl), IM, on days 0 and 2. Calves were reevaluated every other day for 20 days after treatment.

Results—Corneal ulcers healed by day 20 in 48 of 49 (98%) calves treated with florfenicol IM, 39 of 42 (93%) calves treated with florfenicol SC, and 33 of 52 (63%) control calves.

Conclusions and Clinical Relevance—Florfenicol administered SC (1 dose) or IM (2 doses 48 hours apart) was effective for treatment of calves with naturally occurring IBK. ( J Am Vet Med Assoc 2000;216: 62–64)

Abstract

Objective—To determine the efficacy of florfenicol for treatment of calves with naturally occurring infectious bovine keratoconjunctivitis (IBK).

Design—Randomized controlled field trial.

Animals—63 beef calves and 80 dairy calves between 4 and 12 months of age.

Procedure—Calves were randomly assigned to 1 of 3 treatment groups. Calves in the SC treatment group received a single dose of florfenicol (40 mg/kg [18.2 mg/lb] of body weight), SC, on day 0. Calves in the IM treatment group received florfenicol (20 mg/kg [9.1 mg/lb]), IM, on days 0 and 2. Calves in the control group received injections of saline solution (0.9% NaCl), IM, on days 0 and 2. Calves were reevaluated every other day for 20 days after treatment.

Results—Corneal ulcers healed by day 20 in 48 of 49 (98%) calves treated with florfenicol IM, 39 of 42 (93%) calves treated with florfenicol SC, and 33 of 52 (63%) control calves.

Conclusions and Clinical Relevance—Florfenicol administered SC (1 dose) or IM (2 doses 48 hours apart) was effective for treatment of calves with naturally occurring IBK. ( J Am Vet Med Assoc 2000;216: 62–64)