Acellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019–2021)

Elise S. Mauer Park West Veterinary Associates, Mount Pleasant, SC

Search for other papers by Elise S. Mauer in
Current site
Google Scholar
PubMed
Close
 DVM
,
Elizabeth A. Maxwell Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL

Search for other papers by Elizabeth A. Maxwell in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Christina J. Cocca Metropolitan Veterinary Hospital, Copley, OH

Search for other papers by Christina J. Cocca in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Justin Ganjei Veterinary Surgical Centers, Vienna, VA

Search for other papers by Justin Ganjei in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Daniel Spector Animal Medical Center, New York, NY

Search for other papers by Daniel Spector in
Current site
Google Scholar
PubMed
Close
 DVM

Abstract

OBJECTIVE

To report the clinical outcomes of the use of acellular fish skin grafts (FSGs) for the management of complex soft tissue wounds of various etiologies in dogs and cats.

ANIMALS

13 dogs and 4 cats with complex wounds treated with FSGs between February 2019 and March 2021.

PROCEDURES

Medical records were reviewed for information regarding cause, location, size of the wound, management techniques, complications, and clinical outcomes.

RESULTS

In dogs, the number of FSG applications ranged from 1 to 4 (median, 2 graft applications). The time between each application ranged from 4 to 21 days (median, 9.5 days). Time to application of the first FSG ranged from 9 to 210 days (median, 19 days). Wounds closed by second-intention healing following the first fish skin application between 26 and 145 days (median, 71 days; n = 12). In cats, 1 or 2 FSGs were used, and the wounds of 3 of 4 cats healed completely by secondary intention. The wounds of 1 dog and 1 cat did not heal. There were no adverse events attributed to the use of the FSGs.

CLINICAL RELEVANCE

For dogs and cats of the present study, complete healing of most wounds occurred with the use of FSGs, the application of which did not require special training, instruments, or bandage materials.

Abstract

OBJECTIVE

To report the clinical outcomes of the use of acellular fish skin grafts (FSGs) for the management of complex soft tissue wounds of various etiologies in dogs and cats.

ANIMALS

13 dogs and 4 cats with complex wounds treated with FSGs between February 2019 and March 2021.

PROCEDURES

Medical records were reviewed for information regarding cause, location, size of the wound, management techniques, complications, and clinical outcomes.

RESULTS

In dogs, the number of FSG applications ranged from 1 to 4 (median, 2 graft applications). The time between each application ranged from 4 to 21 days (median, 9.5 days). Time to application of the first FSG ranged from 9 to 210 days (median, 19 days). Wounds closed by second-intention healing following the first fish skin application between 26 and 145 days (median, 71 days; n = 12). In cats, 1 or 2 FSGs were used, and the wounds of 3 of 4 cats healed completely by secondary intention. The wounds of 1 dog and 1 cat did not heal. There were no adverse events attributed to the use of the FSGs.

CLINICAL RELEVANCE

For dogs and cats of the present study, complete healing of most wounds occurred with the use of FSGs, the application of which did not require special training, instruments, or bandage materials.

Contributor Notes

Corresponding author: Dr. Maxwell (emaxwell@ufl.edu)
  • 1.

    Campbell BG. Moist wound healing in dogs and cats: using MRDs to improve care. Today ’s Vet Pract. 2015. Accessed March 22, 2021. https://todaysveterinarypractice.com/moist-wound-healing-the-new-standard-of-care/

    • Search Google Scholar
    • Export Citation
  • 2.

    Prpich CY, Santamaria AC, Simcock JO, Wong HK, Nimmo JS, Kuntz CA. Second intention healing after wide local excision of soft tissue sarcomas in the distal aspects of the limbs in dogs: 31 cases (2005–2012). J Am Vet Med Assoc. 2014;244(2):187194.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Dorweiler B, Trinh TT, Dünschede F, et al. The marine omega3 wound matrix for treatment of complicated wounds: a multicenter experience report. Article in German. Gefasschirurgie. 2018;23(suppl 2):4655.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Baldursson BT, Kjartansson H, Konr ádsdóttir F, Gudnason P, Sigurjonsson GF, Lund SH. Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a noninferiority study: a noninferiority study. Int J Low Extrem Wounds. 2015;14(1):3743.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Kirsner RS, Margolis DJ, Baldursson BT, et al. Fish skin grafts compared to human amnion/chorion membrane allografts: a double-blind, prospective, randomized clinical trial of acute wound healing. Wound Repair Regen. 2020;28(1):7580.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Magnusson S, Baldursson BT, Kjartansson H, Rolfsson O, Sigurjonsson GF. Regenerative and antibacterial properties of acellular fish skin grafts and human amnion/chorion membrane: implications for tissue preservation in combat casualty care. Mil Med. 2017;182(S1):383388.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Magnusson S, Winters C, Baldursson BT, Kjartansson H, Rolfsson O, Sigurjonsson F. Acceleration of wound healing through utilization of fish skin containing omega-3 fatty acids. Today ’s Wound Clin. 2016. Accessed March 22, 2021. https://www.todayswoundclinic.com/articles/acceleration-wound-healing-through-utilization-fish-skin-containing-omega-3-fatty-acids

    • Search Google Scholar
    • Export Citation
  • 8.

    Magnússon S, Baldursson BT, Kjartansson H, et al. Decellularized fish skin: characteristics that support tissue repair. Article in Icelandic. Laeknabladid. 2015;101(12):567573.

    • Search Google Scholar
    • Export Citation
  • 9.

    Magnusson S, Kjartansson H, Baldursson BT, et al. Acellular fish skin grafts and pig urinary bladder matrix assessed in the collagen-induced arthritis mouse model. Int J Low Extrem Wounds. 2018;17(4):275281.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Boháč M, Danišovič Ľ, Koller J, Drag úňov á J, Varga I. What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study. Eur J Histochem. 2018;62(1):2873.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Bush K, Gertzman AA. Process development and manufacturing of human and animal acellular dermal matrices. In: Albanna MZ, Holmes JH, eds. Skin Tissue Engineering and Regenerative Medicine. Elsevier; 2016:83103.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Carlsson AH, Gronet EM, Rose LF, et al. Clinical applications of acellular dermal matrices in reconstructive surgery. In: Albanna MZ, Holmes JH, eds. Skin Tissue Engineering and Regenerative Medicine. Elsevier; 2016:109124.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Stone R II, Saathoff EC, Larson DA, et al. Accelerated wound closure of deep partial thickness burns with acellular fish skin graft. Int J Mol Sci. 2021;22(4):1590.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Yang CK, Polanco TO, Lantis JC II. A prospective, postmarket, compassionate clinical evaluation of a novel acellular fish-skin graft which contains omega-3 fatty acids for the closure of hard-to-heal lower extremity chronic ulcers. Wounds. 2016;28(4):112118.

    • Search Google Scholar
    • Export Citation
  • 15.

    Woodrow T, Chant T, Chant H. Treatment of diabetic foot wounds with acellular fish skin graft rich in omega-3: a prospective evaluation. J Wound Care. 2019;28(2):7680.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Michael S, Winters C, Khan M. Acellular fish skin graft use for diabetic lower extremity wound healing: a retrospective study of 58 ulcerations and a literature review. Wounds. 2019;31(10):262268.

    • Search Google Scholar
    • Export Citation

Advertisement