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Effects of housing environment on oral absorption of acetaminophen in healthy Beagles
Abstract
OBJECTIVE
To evaluate the effects of housing environment on oral absorption of acetaminophen in dogs.
ANIMALS
6 healthy Beagles.
PROCEDURES
Acetaminophen (325 mg, PO; mean dose, 31.1 mg/kg) was administered in a crossover study design with dogs housed in their normal environment or in a cage in an unfamiliar environment. There was a 7-day washout period between phases. Blood samples were collected for 24 hours following acetaminophen administration, and plasma acetaminophen concentrations were determined with high-pressure liquid chromatography.
RESULTS
A 2-compartment model with lag time was the best fit for both phases of the study. None of the primary or secondary pharmacokinetic parameters were significantly different between the 2 housing environments.
CLINICAL RELEVANCE
Findings suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen.
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