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Diffusion-weighted and perfusion-weighted magnetic resonance imaging of the prostate gland of healthy adult dogs

Florian Willmitzer Dr Med Vet1, Francesca Del Chicca Dr Med Vet, PhD1, Patrick R. Kircher Dr Med Vet, PhD1, Adriano Wang-Leandro DVM, PhD1, Peter W. Kronen Dr Med Vet2, Dagmar Verdino Dr Med Vet2, Daniel Rüfenacht Dr Med3, Beat Porcellini Dr Med4, and Henning Richter Dr Med Vet, PhD1,2,3,4
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  • 1 1Clinic for Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 2 2Veterinary Anaesthesia Services-International, Zürcherstrasse 39, 8400 Winterthur, Switzerland.
  • | 3 3Department of Neuroradiology, Clinic Hirslanden, Witellikerstrasse 40, 8032 Zurich, Switzerland.
  • | 4 4Department of Abdominal and Urogenital Radiology, Clinic Hirslanden, Witellikerstrasse 40, 8032 Zurich, Switzerland.

Abstract

OBJECTIVE

To describe diffusion and perfusion characteristics of the prostate gland of healthy sexually intact adult dogs as determined by use of diffusion-weighted and perfusion-weighted MRI.

ANIMALS

12 healthy sexually intact adult Beagles.

PROCEDURES

Ultrasonography of the prostate gland was performed. Subsequently, each dog was anesthetized, and morphological, diffusion-weighted, and perfusion-weighted MRI of the caudal aspect of the abdomen was performed. The apparent diffusion coefficient was calculated for the prostate gland parenchyma in diffusion-weighted MRI images in the central ventral and peripheral dorsal areas. Perfusion variables were examined in multiple regions of interest (ROIs) in the ventral and dorsal areas of the prostate gland and in the gluteal musculature. Signal intensity was determined, and a time-intensity curve was generated for each ROI.

RESULTS

Results of ultrasonographic examination of the prostate gland revealed no abnormalities for any dog. Median apparent diffusion coefficient of the prostate gland was 1.51 × 10−3 mm2/s (range, 1.04 × 10−3 mm2/s to 1.86 × 10−3 mm2/s). Perfusion-weighted MRI variables for the ROIs differed between the prostate gland parenchyma and gluteal musculature.

CONCLUSIONS AND CLINICAL RELEVANCE

Results provided baseline information about diffusion and perfusion characteristics of the prostate gland in healthy sexually intact adult dogs. Additional studies with dogs of various ages and breeds, with and without abnormalities of the prostate gland, will be necessary to validate these findings and investigate clinical applications.

Contributor Notes

Dr. Willmitzer's present address is VET Zentrum AG, Riedäckerstrasse 7, 8422 Winterthur, Switzerland.

Drs. Willmitzer and Del Chicca contributed equally to the manuscript.

Address correspondence to Dr. Willmitzer (fwillmitzer@vetzentrum.ch).