Editorial Type:
Ophthalmology

Changes in pupil size and intraocular pressure after topical application of 0.5% tropicamide to the eyes of dogs sedated with butorphanol

Sophie Jugant Département des Sciences Cliniques des animaux de compagnie, de sports et de loisirs, Université Fédérale de Toulouse Midi-Pyrénées, 31076 Toulouse Cedex 3, France.

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Aure-Eline Grillot Département des Sciences Cliniques des animaux de compagnie, de sports et de loisirs, Université Fédérale de Toulouse Midi-Pyrénées, 31076 Toulouse Cedex 3, France.

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Faouzi Lyarzhri Département des Sciences Biologiques et Fonctionnelles, Université Fédérale de Toulouse Midi-Pyrénées, 31076 Toulouse Cedex 3, France.

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Alain Régnier Département des Sciences Cliniques des animaux de compagnie, de sports et de loisirs, Université Fédérale de Toulouse Midi-Pyrénées, 31076 Toulouse Cedex 3, France.

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Jean-Yves Douet Département des Sciences Cliniques des animaux de compagnie, de sports et de loisirs, Université Fédérale de Toulouse Midi-Pyrénées, 31076 Toulouse Cedex 3, France.

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DOI:
https://doi.org/10.2460/ajvr.80.1.95
Volume/Issue:
Volume 80: Issue 1
Online Publication Date:
01 Jan 2019
Restricted access
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Abstract

OBJECTIVE: To assess changes in pupil size and intraocular pressure (IOP) following topical application of a 0.5% tropicamide solution in the eyes of healthy butorphanol-sedated dogs.

ANIMALS: 12 healthy adult Beagles.

PROCEDURES: In a randomized crossover study consisting of 2 treatment periods with a 1-week washout between periods, dogs received an IM injection of butorphanol (0.2 mg/kg) or an equal volume of sterile saline (0.9% NaCl) solution. For each dog, 1 drop of 0.5% tropicamide ophthalmic solution was topically instilled in one eye and 1 drop of artificial tear solution was topically instilled in the other eye 10 minutes after the IM injection and again 5 minutes later. Extent of sedation, pupil size, and IOP were evaluated from 20 minutes before to 80 minutes after the IM injection and compared among treatment combinations.

RESULTS: Butorphanol induced mild (n = 9) or moderate (3) sedation in all dogs and slightly delayed the onset of, but did not prevent, tropicamide-induced mydriasis. Butorphanol caused a significant increase in IOP, which was not exacerbated by tropicamide-induced mydriasis; however, that increase was generally not sufficient to exceed the upper limit of the IOP reference range.

CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that butorphanol did not prevent tropicamide-induced mydriasis but did increase the IOP in ophthalmologically normal Beagles. Although the butorphanol-induced increase in IOP did not appear clinically relevant for the dogs of this study, that may not be true for dogs with glaucoma, and care should be taken when butorphanol is administered to such dogs.

Abstract

OBJECTIVE: To assess changes in pupil size and intraocular pressure (IOP) following topical application of a 0.5% tropicamide solution in the eyes of healthy butorphanol-sedated dogs.

ANIMALS: 12 healthy adult Beagles.

PROCEDURES: In a randomized crossover study consisting of 2 treatment periods with a 1-week washout between periods, dogs received an IM injection of butorphanol (0.2 mg/kg) or an equal volume of sterile saline (0.9% NaCl) solution. For each dog, 1 drop of 0.5% tropicamide ophthalmic solution was topically instilled in one eye and 1 drop of artificial tear solution was topically instilled in the other eye 10 minutes after the IM injection and again 5 minutes later. Extent of sedation, pupil size, and IOP were evaluated from 20 minutes before to 80 minutes after the IM injection and compared among treatment combinations.

RESULTS: Butorphanol induced mild (n = 9) or moderate (3) sedation in all dogs and slightly delayed the onset of, but did not prevent, tropicamide-induced mydriasis. Butorphanol caused a significant increase in IOP, which was not exacerbated by tropicamide-induced mydriasis; however, that increase was generally not sufficient to exceed the upper limit of the IOP reference range.

CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that butorphanol did not prevent tropicamide-induced mydriasis but did increase the IOP in ophthalmologically normal Beagles. Although the butorphanol-induced increase in IOP did not appear clinically relevant for the dogs of this study, that may not be true for dogs with glaucoma, and care should be taken when butorphanol is administered to such dogs.

Contributor Notes

Address correspondence to Dr. Douet (jy.douet@envt.fr).
Cover American Journal of Veterinary Research
American Journal of Veterinary Research
Publication Date:
01 Jan 2019

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