Cover American Journal of Veterinary Research
American Journal of Veterinary Research
ISSN:
0002-9645
Publication Date:
01 Feb 2018

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Editorial Type:
Theriogenology

Effect of metoclopramide treatment of bitches during the first week of lactation on serum prolactin concentration, milk composition, and milk yield and on weight gain of their puppies

Stefanie R. Keller DVM1, Zsolt Abonyi-Tóth MS2, Norbert Sprenger PhD3, Sean C. Austin PhD4, Brigitta A. C. Wichert DVM, PD habil5, Annette Liesegang DVM, prof habil6, Christine H. Y. Oei MS7, Orsolya Balogh DVM, PhD8, and Iris M. Reichler DVM, Prof habil9
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  • 1 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 2 Department of Biomathematics and Informatics, University of Veterinary Medicine, Istvan u. 2, 1078 Budapest, Hungary.
  • | 3 Nestlé Research Centre, Nestec Ltd, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland.
  • | 4 Nestlé Research Centre, Nestec Ltd, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland.
  • | 5 Institute of Animal Nutrition, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 6 Institute of Animal Nutrition, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 7 Department of Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands.
  • | 8 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 9 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
DOI:
https://doi.org/10.2460/ajvr.79.2.233
Volume/Issue:
Volume 79: Issue 2
Online Publication Date:
01 Feb 2018
Restricted access
Reprints and Permissions Purchase Article

Abstract

OBJECTIVE To investigate effects of metoclopramide orally administered to healthy bitches on serum prolactin and milk lactose concentrations, gross energy, and dry matter content and on puppy weight gain during early lactation.

ANIMALS 20 client-owned bitches and their 121 puppies.

PROCEDURES 10 bitches received metoclopramide (0.2 mg/kg, PO, q 6 h for 6 days; treatment group) starting 10 to 24 hours after birth of the last puppy of the litter (day 0), and 10 bitches served as the control group. Blood and milk samples from all bitches were collected on days 0, 1, 2, 4, and 6. Milk samples for days 1 and 2 and days 4 and 6 were pooled because of small volume. Puppies were weighed twice daily.

RESULTS Serum prolactin concentration increased significantly over time in both groups, and no treatment effect was detected. When day-to-day changes were analyzed, the prolactin concentration increased from day 0 to day 1 in the treatment group but not in the control group. Milk lactose concentration increased significantly and was higher in the treatment group than in the control group. Milk dry matter content was unchanged, whereas the time course for milk gross energy content differed significantly between treatment and control bitches. Puppy weight gain was not affected by metoclopramide treatment.

CONCLUSIONS AND CLINICAL RELEVANCE Oral administration of metoclopramide to healthy bitches after parturition induced a transient increase in serum prolactin concentration and stimulated milk lactose production. It is likely bitches with insufficient or delayed milk production could benefit from metoclopramide treatment.

Contributor Notes

Drs. Balogh and Reichler contributed equally to the manuscript.

Address correspondence to Dr. Balogh (obalogh@vetclinics.uzh.ch).