• 1. Mila H, Feugier A, Grellet A, et al. Inadequate passive immune transfer in puppies: definition, risk factors and prevention in a large multi-breed kennel. Prev Vet Med 2014;116:209213.

    • Search Google Scholar
    • Export Citation
  • 2. Chastant-Maillard S, Freyburger L, Marcheteau E, et al. Timing of the intestinal barrier closure in puppies. Reprod Domest Anim 2012;47:190193.

    • Search Google Scholar
    • Export Citation
  • 3. Marti JA, Fernandez S. Clinical approach to mammary gland disease. In: England G, von Heimendahl A, eds. BSAVA manual of canine and feline reproduction and neonatology Gloucester, England: British Small Animal Veterinary Association, 2010;155165.

    • Search Google Scholar
    • Export Citation
  • 4. Goericke-Pesch S, Georgiev P, Atanasov A, et al. Treatment with suprelorin in a pregnant cat. J Feline Med Surg 2013;15:357360.

  • 5. Romagnoli S, Milani C, Perin S, et al. Effect of an injectable cabergoline formulation on serum prolactin (PRL) and milk secretion in early postpartum Beagle bitches. Reprod Domest Anim 2009;44:148151.

    • Search Google Scholar
    • Export Citation
  • 6. Jöchle W, Ballabio R, di Salle E. Inhibition of lactation in the Beagle bitch with the prolactin inhibitor cabergoline (FCE 21336): dose response and aspects of long-term safety. Theriogenology 1987;27:799810.

    • Search Google Scholar
    • Export Citation
  • 7. Jöchle W. Prolactin in canine and feline reproduction. Reprod Domest Anim 1997;32:183193.

  • 8. Ostrom KM. A review of the hormone prolactin during lactation. Prog Food Nutr Sci 1990;14:143.

  • 9. Crowley WR. Neuroendocrine regulation of lactation and milk production. Compr Physiol 2015;5:255291.

  • 10. Freeman ME, Kanyicska B, Lerant A, et al. Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000;80:15231631.

  • 11. Lamberts SW, Macleod RM. Regulation of prolactin secretion at the level of the lactotroph. Physiol Rev 1990;70:279318.

  • 12. Koch A, Hoppen HO, Dieleman SJ, et al. Effects of the dopamine agonist cabergoline on the pulsatile and TRH-induced secretion of prolactin, LH, and testosterone in male Beagle dogs. Theriogenology 2006;65:16661677.

    • Search Google Scholar
    • Export Citation
  • 13. Leong DA, Frawley LS, Neill JD. Neuroendocrine control of prolactin secretion. Annu Rev Physiol 1983;45:109127.

  • 14. Concannon PW, Butler WR, Hansel W, et al. Parturition and lactation in the bitch: serum progesterone, cortisol and prolactin. Biol Reprod 1978;19:11131118.

    • Search Google Scholar
    • Export Citation
  • 15. Onclin K, Verstegen JP. Secretion patterns of plasma prolactin and progesterone in pregnant compared with non-pregnant dioestrous Beagle bitches. J Reprod Fertil Suppl 1997;51:203208.

    • Search Google Scholar
    • Export Citation
  • 16. Turkington RW, Brew K, Vanaman TC, et al. The hormonal control of lactose synthetase in the developing mouse mammary gland. J Biol Chem 1968;243:33823387.

    • Search Google Scholar
    • Export Citation
  • 17. Turkington RW, Hill RL. Lactose synthetase: progesterone inhibition of the induction of alpha-lactalbumin. Science 1969;163:14581460.

    • Search Google Scholar
    • Export Citation
  • 18. Kuhn NJ, Carrick DT, Wilde CJ. Lactose synthesis: the possibilities of regulation. J Dairy Sci 1980;63:328336.

  • 19. Ramakrishnan B, Qasba PK. Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I. J Mol Biol 2001;310:205218.

    • Search Google Scholar
    • Export Citation
  • 20. Holt C. Swelling of Golgi vesicles in mammary secretory cells and its relation to the yield and quantitative composition of milk. J Theor Biol 1983;101:247261.

    • Search Google Scholar
    • Export Citation
  • 21. Oftedal OT. Lactation in the dog: milk composition and intake by puppies. J Nutr 1984;114:803812.

  • 22. Macias Rostami S, Benet T, Spears J, et al. Milk oligosaccharides over time of lactation from different dog breeds. PLoS One 2014;9:e99824.

    • Search Google Scholar
    • Export Citation
  • 23. Adkins Y, Lepine AJ, Lonnerdal B. Changes in protein and nutrient composition of milk throughout lactation in dogs. Am J Vet Res 2001;62:12661272.

    • Search Google Scholar
    • Export Citation
  • 24. Powe CE, Allen M, Puopolo KM, et al. Recombinant human prolactin for the treatment of lactation insufficiency. Clin Endocrinol (Oxf) 2010;73:645653.

    • Search Google Scholar
    • Export Citation
  • 25. Tonini M, Cipollina L, Poluzzi E, et al. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther 2004;19:379390.

    • Search Google Scholar
    • Export Citation
  • 26. Plumb DC. Metoclopramide HCl. In: Plumb's veterinary drug handbook. 7th ed. Ames, Iowa: Wiley-Blackwell, 2011;677680.

  • 27. Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274279.

  • 28. Zuppa AA, Sindico P, Orchi C, et al. Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production. J Pharm Pharm Sci 2010;13:162174.

    • Search Google Scholar
    • Export Citation
  • 29. Kauppila A, Kivinen S, Ylikorkala O. A dose response relation between improved lactation and metoclopramide. Lancet 1981;1:11751177.

  • 30. de Gezelle H, Ooghe W, Thiery M, et al. Metoclopramide and breast milk. Eur J Obstet Gynecol Reprod Biol 1983;15:3136.

  • 31. Kauppila A, Anunti P, Kivinen S, et al. Metoclopramide and breast feeding: efficacy and anterior pituitary responses of the mother and the child. Eur J Obstet Gynecol Reprod Biol 1985;19:1922.

    • Search Google Scholar
    • Export Citation
  • 32. Ehrenkranz RA, Ackerman BA. Metoclopramide effect on faltering milk production by mothers of premature infants. Pediatrics 1986;78:614620.

    • Search Google Scholar
    • Export Citation
  • 33. Ingram J, Taylor H, Churchill C, et al. Metoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2012;97:F241F245.

    • Search Google Scholar
    • Export Citation
  • 34. Ertl T, Sulyok E, Ezer E, et al. The influence of metoclopramide on the composition of human breast milk. Acta Paediatr Hung 1991;31:415422.

    • Search Google Scholar
    • Export Citation
  • 35. Fife S, Gill P, Hopkins M, et al. Metoclopramide to augment lactation, does it work? A randomized trial. J Matern Fetal Neonatal Med 2011;24:13171320.

    • Search Google Scholar
    • Export Citation
  • 36. Hansen WF, McAndrew S, Harris K, et al. Metoclopramide effect on breastfeeding the preterm infant: a randomized trial. Obstet Gynecol 2005;105:383389.

    • Search Google Scholar
    • Export Citation
  • 37. Kolster KA, Panciera DL, Purswell BJ, et al. Control of prolactin secretion in canine hypothyroidism. Clin Theriogenol 2010;2:185190.

    • Search Google Scholar
    • Export Citation
  • 38. Koivisto MB, Eschricht F, Urhausen C, et al. Effects of short-term hyper- and hypoprolactinaemia on hormones of the pituitary, gonad and -thyroid axis and on semen quality in male Beagles. Reprod Domest Anim 2009;44(suppl 2):320325.

    • Search Google Scholar
    • Export Citation
  • 39. Davidson AP. Reproductive disorders in the dog and bitch with genetic concerns, in Proceedings. Voorjarsdagen Vet Conf, 2007;157161.

    • Search Google Scholar
    • Export Citation
  • 40. Romagnoli S, Lopate C. Control of mammary gland function in the bitch and queen: a review. Clin Theriogenol 2012;4:196205.

  • 41. Rickard V. Birth and the first 24 hours. In: Peterson ME, Kutzler MA, eds. Small animal pediatrics: the first 12 months of life. St Louis: Elsevier Saunders, 2011;1119.

    • Search Google Scholar
    • Export Citation
  • 42. Campbell-Yeo ML, Allen AC, Joseph KS, et al. Effect of domperidone on the composition of preterm human breast milk. Pediatrics 2010;125:e107e114.

    • Search Google Scholar
    • Export Citation
  • 43. Gobello C, Bolognani F, de la Sota RL, et al. Twenty-four-hour profiles of serum prolactin and luteinizing hormone in anoestrous crossbred bitches. Reprod Domest Anim 2001;36:4145.

    • Search Google Scholar
    • Export Citation
  • 44. Corrada Y, Castex G, Sosa Y, et al. Secretory patterns of prolactin in dogs: circannual and ultradian rhythms. Reprod Domest Anim 2003;38:219223.

    • Search Google Scholar
    • Export Citation
  • 45. Michel KE. Nutritional management of body weight. In: Fascetti AJ, Delaney SJ, eds. Applied veterinary clinical nutrition. Chichester, England: Wiley-Blackwell, 2012; 109124.

    • Search Google Scholar
    • Export Citation
  • 46. Okkens AC, Dieleman SJ, Bevers MM, et al. Evidence for the non-involvement of the uterus in the lifespan of the corpus luteum in the cyclic dog. Vet Q 1985;7:169173.

    • Search Google Scholar
    • Export Citation
  • 47. Jensen RL, Johnson AK, Wilborn RR, et al. A case report on the use of domperidone for management of agalactia in a queen. Clin Theriogenol 2016;8:121126.

    • Search Google Scholar
    • Export Citation
  • 48. Frawley LS, Mulchahey JJ, Neill JD. Nursing induces a biphasic release of prolactin in rhesus monkeys. Endocrinology 1983;112:558561.

    • Search Google Scholar
    • Export Citation
  • 49. Jonas W, Woodside B. Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young. Horm Behav 2016;77:167181.

    • Search Google Scholar
    • Export Citation
  • 50. Mattheij JA, Swarts HJ, Verstijnen CP. The response of plasma prolactin to suckling during normal and prolonged lactation in the rat. Horm Res 1984;20:261268.

    • Search Google Scholar
    • Export Citation
  • 51. Mattheij JA, Gruisen EF, Swarts JJ. The suckling-induced rise of plasma prolactin in lactating rats: its dependence on stage of lactation and litter size. Horm Res 1979;11:325336.

    • Search Google Scholar
    • Export Citation
  • 52. Günzel-Apel AR, Beste N, Nottorf S, et al. Comparison of selected endocrine parameters during luteal phase and pregnancy in German Shepherd Dogs and Beagles. Reprod Domest Anim 2009;44:5964.

    • Search Google Scholar
    • Export Citation
  • 53. Bostedt H. Erkrankungen des Gesäuges/diseases of the mammary gland [in German] In: Günzel-Apel AR, Bostedt H, eds. Reproduktionsmedizin und Neonatologie von Hund und Katze. Stuttgart, Germany: Schattauer, 2016;186220.

    • Search Google Scholar
    • Export Citation
  • 54. Saint L, Smith M, Hartmann PE. The yield and nutrient content of colostrum and milk of women from giving birth to 1 month post-partum. Br J Nutr 1984;52:8795.

    • Search Google Scholar
    • Export Citation
  • 55. Hartmann PE. Changes in the composition and yield of the mammary secretion of cows during the initiation of lactation. J Endocrinol 1973;59:231247.

    • Search Google Scholar
    • Export Citation
  • 56. Chahoud I, Paumgartten FJ. Influence of litter size on the postnatal growth of rat pups: is there a rationale for litter-size standardization in toxicity studies? Environ Res 2009;109:10211027.

    • Search Google Scholar
    • Export Citation
  • 57. Lau Moon Lin M, Robinson PD, Flank J, et al. The safety of metoclopramide in children: a systematic review and meta-analysis. Drug Saf 2016;39:675687.

    • Search Google Scholar
    • Export Citation

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Effect of metoclopramide treatment of bitches during the first week of lactation on serum prolactin concentration, milk composition, and milk yield and on weight gain of their puppies

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  • 1 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 2 Department of Biomathematics and Informatics, University of Veterinary Medicine, Istvan u. 2, 1078 Budapest, Hungary.
  • | 3 Nestlé Research Centre, Nestec Ltd, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland.
  • | 4 Nestlé Research Centre, Nestec Ltd, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland.
  • | 5 Institute of Animal Nutrition, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 6 Institute of Animal Nutrition, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 7 Department of Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands.
  • | 8 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
  • | 9 Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.

Abstract

OBJECTIVE To investigate effects of metoclopramide orally administered to healthy bitches on serum prolactin and milk lactose concentrations, gross energy, and dry matter content and on puppy weight gain during early lactation.

ANIMALS 20 client-owned bitches and their 121 puppies.

PROCEDURES 10 bitches received metoclopramide (0.2 mg/kg, PO, q 6 h for 6 days; treatment group) starting 10 to 24 hours after birth of the last puppy of the litter (day 0), and 10 bitches served as the control group. Blood and milk samples from all bitches were collected on days 0, 1, 2, 4, and 6. Milk samples for days 1 and 2 and days 4 and 6 were pooled because of small volume. Puppies were weighed twice daily.

RESULTS Serum prolactin concentration increased significantly over time in both groups, and no treatment effect was detected. When day-to-day changes were analyzed, the prolactin concentration increased from day 0 to day 1 in the treatment group but not in the control group. Milk lactose concentration increased significantly and was higher in the treatment group than in the control group. Milk dry matter content was unchanged, whereas the time course for milk gross energy content differed significantly between treatment and control bitches. Puppy weight gain was not affected by metoclopramide treatment.

CONCLUSIONS AND CLINICAL RELEVANCE Oral administration of metoclopramide to healthy bitches after parturition induced a transient increase in serum prolactin concentration and stimulated milk lactose production. It is likely bitches with insufficient or delayed milk production could benefit from metoclopramide treatment.

Abstract

OBJECTIVE To investigate effects of metoclopramide orally administered to healthy bitches on serum prolactin and milk lactose concentrations, gross energy, and dry matter content and on puppy weight gain during early lactation.

ANIMALS 20 client-owned bitches and their 121 puppies.

PROCEDURES 10 bitches received metoclopramide (0.2 mg/kg, PO, q 6 h for 6 days; treatment group) starting 10 to 24 hours after birth of the last puppy of the litter (day 0), and 10 bitches served as the control group. Blood and milk samples from all bitches were collected on days 0, 1, 2, 4, and 6. Milk samples for days 1 and 2 and days 4 and 6 were pooled because of small volume. Puppies were weighed twice daily.

RESULTS Serum prolactin concentration increased significantly over time in both groups, and no treatment effect was detected. When day-to-day changes were analyzed, the prolactin concentration increased from day 0 to day 1 in the treatment group but not in the control group. Milk lactose concentration increased significantly and was higher in the treatment group than in the control group. Milk dry matter content was unchanged, whereas the time course for milk gross energy content differed significantly between treatment and control bitches. Puppy weight gain was not affected by metoclopramide treatment.

CONCLUSIONS AND CLINICAL RELEVANCE Oral administration of metoclopramide to healthy bitches after parturition induced a transient increase in serum prolactin concentration and stimulated milk lactose production. It is likely bitches with insufficient or delayed milk production could benefit from metoclopramide treatment.

Contributor Notes

Drs. Balogh and Reichler contributed equally to the manuscript.

Address correspondence to Dr. Balogh (obalogh@vetclinics.uzh.ch).