Cover American Journal of Veterinary Research
American Journal of Veterinary Research
ISSN:
0002-9645
Publication Date:
01 Dec 2018

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Editorial Type:
Diagnostic Imaging

Influence of injection protocol and measurement technique on computed tomographic assessment of glomerular filtration rate in healthy Beagles

Michael Wallimann MVetMed1, Henning Richter Dr Med Vet2, Nadja S. Sieber-Ruckstuhl Dr Med Vet3, Alexandra Blaser Dr Med Vet4, Thomas C. Gent PhD5, Stefanie D. Krämer PhD6, Guido Santner7, Patrick R. Kircher Dr Med Vet8, and Matthias Dennler Dr Med Vet9
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  • 1 Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 2 Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 3 Clinic of Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 4 Clinic of Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 5 Section of Anesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 6 Institute of Pharmaceutical Sciences ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • | 7 Sprachwerk GmbH, Technoparkstrasse 1, 8005 Zurich, Switzerland.
  • | 8 Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
  • | 9 Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
DOI:
https://doi.org/10.2460/ajvr.79.12.1298
Volume/Issue:
Volume 79: Issue 12
Online Publication Date:
01 Dec 2018
Restricted access
Reprints and Permissions Purchase Article

Abstract

OBJECTIVE To compare values of CT-derived glomerular filtration rate (GFR) determined by 3 contrast-medium injection protocols and 4 measurement techniques in healthy Beagles.

ANIMALS 9 healthy Beagles (mean ± SD weight, 13.2 ± 1.6 kg).

PROCEDURES Each dog underwent 3 iohexol-injection protocols (700 mg of iodine/kg administered at a constant rate over 20 seconds, 700 mg of iodine/kg administered following an exponentially decelerated injection over 20 seconds, and 350 mg of iodine/kg at a constant rate over 10 seconds) during dynamic, whole renal-volume CT in randomized order with an interval of ≥ 7 days between experiments. Values of GFR determined from Patlak plots derived by use of 4 measurement techniques (standard transverse section, optimized transverse section, dorsal reconstruction, and volume calculation techniques) were compared.

RESULTS The measurement technique influenced the mean ± SD GFR results (standard transverse section technique, 2.49 ± 0.54 mL/kg/min; optimized transverse section technique, 2.72 ± 0.52 mL/kg/min; dorsal reconstruction technique, 3.00 ± 0.60 mL/kg/min, and volume calculation technique, 2.48 ± 0.51 mL/kg/min). The lower iodine dose resulted in a significantly higher GFR value (3.00 ± 0.65 mL/kg/min), compared with that achieved with either higher dose administration (constant rate injection, 2.54 ± 0.45 mL/kg/min and exponentially decelerated injection, 2.47 ± 0.48 mL/kg/min).

CONCLUSIONS AND CLINICAL RELEVANCE In healthy Beagles, the CT-derived GFR measurements obtained after injection of a full dose of contrast medium were reduced, compared with measurements obtained after injection of a half dose. This finding is important with regard to potential nephrotoxicosis in dogs with impaired renal function and for GFR measurement with CT-contrast medium protocols.

Contributor Notes

Mr. Wallimann's present address is Gross-und Kleintierpraxis, Hofstrasse 8, 6374 Buochs, Switzerland.

Mr. Santner's present address is IngCH – Engineers Shape our Future, Klosbachstrasse 107, 8032 Zurich, Switzerland. (Krämer).

Address correspondence to Dr. Dennler (mdennler@vetclinics.uzh.ch).