Cover American Journal of Veterinary Research
American Journal of Veterinary Research
ISSN:
0002-9645
Publication Date:
01 Jan 2017

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Editorial Type:
Ophthalmology

Effects of diurnal variation and anesthetic agents on intraocular pressure in Syrian hamsters (Mesocricetus auratus)

Seyed Mehdi Rajaei DVM, DVSc1, Maneli Ansari Mood DVM, DVSc2, Mohammad Reza Paryani DVM, PhD3, and David L. Williams MA, VetMD, PhD4
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  • 1 Department of Clinical Sciences, College of Veterinary Medicine, Karaj Branch, Islamic Azad University, Alborz, Iran.
  • | 2 Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • | 3 Department of Basic Sciences, College of Veterinary Medicine, Karaj Branch, Islamic Azad University, Alborz, Iran
  • | 4 Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, England.
DOI:
https://doi.org/10.2460/ajvr.78.1.85
Volume/Issue:
Volume 78: Issue 1
Online Publication Date:
01 Jan 2017
Restricted access
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Abstract

OBJECTIVE

To determine effects of diurnal variation and anesthetic agents on intraocular pressure (IOP) in Syrian hamsters (Mesocricetus auratus).

ANIMALS

90 healthy adult Syrian hamsters (45 males and 45 females).

PROCEDURES

IOP was measured with a rebound tonometer. In phase 1, IOP was measured in all hamsters 3 times during a 24-hour period (7 am, 3 pm, and 11 pm). In phase 2, hamsters were assigned to 5 groups (18 animals [9 males and 9 females]/group). Each group received an anesthetic agent or combination of anesthetic agents (ketamine hydrochloride, xylazine hydrochloride, diazepam, ketamine-diazepam [KD], or ketamine-xylazine [KX] groups) administered via the IP route. The IOP was measured before (time 0 [baseline]) and 10, 30, 60, 90, 120, and 150 minutes after administration of drugs.

RESULTS

Mean ± SD IOP values were 2.58 ± 0.87 mm Hg, 4.46 ± 1.58 mm Hg, and 5.96 ± 1.23 mm Hg at 7 am, 3 pm, and 11 pm, respectively. Mean baseline IOP was 6.25 ± 0.28 mm Hg, 6.12 ± 0.23 mm Hg, 5.75 ± 0.64 mm Hg, 5.12 ± 1.40 mm Hg, and 4.50 ± 1.30 mm Hg for the ketamine, xylazine, diazepam, KD, and KX groups, respectively. A significant decrease in IOP, compared with baseline IOP, was detected in only the KX group at 30, 60, and 90 minutes after drug administration.

CONCLUSIONS AND CLINICAL RELEVANCE

Maximum IOP in Syrian hamsters was detected at night. The ketamine-xylazine anesthetic combination significantly decreased IOP in Syrian hamsters.

Contributor Notes

Address correspondence to Dr. Rajaei (mehdi_l3r@hotmail.com).