Advertisement
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1. Hanson IR, Hingson RA. The use of xylocaine, a new local anesthetic, in surgery, obstetrics and therapeutics. Curr Res Anesth Analg 1950; 29: 136–147.
-
2. Griffin EM, Prystowsky H, Hingson RA, et al. The use of topical anaesthesia of the peritoneum in poor risk surgery and in augmenting inadequate vertebral conduction anaesthesia. N Z Med J 1951; 50: 31–33.
-
3. Kahokehr A, Sammour T, Vather R, et al. Systemic levels of local anaesthetic after intra-peritoneal application—a systematic review. Anaesth Intensive Care 2010; 38: 623–638.
-
4. Buck L, Varras MN, Miskry T, et al. Intraperitoneal bupivacaine for the reduction of postoperative pain following operative laparoscopy: a pilot study and review of the literature. J Obstet Gynaecol 2004; 24: 448–451.
-
5. Malhotra N, Chanana C, Roy KK, et al. To compare the efficacy of two doses of intraperitoneal bupivacaine for pain relief after operative laparoscopy in gynecology (Erratum published in Arch Gynecol Obstet 2009; 279: 611). Arch Gynecol Obstet 2007; 276: 323–326.
-
6. Freilich DA, Houck CS, Meier PM, et al. The effectiveness of aerosolized intraperitoneal bupivacaine in reducing postoperative pain in children undergoing robotic-assisted laparoscopic pyeloplasty. J Pediatr Urol 2008; 4: 337–340.
-
7. Kang H, Kim BG. Intraperitoneal ropivacaine for effective pain relief after laparoscopic appendectomy: a prospective, randomized, double-blind, placebo-controlled study. J Int Med Res 2010; 38: 821–832.
-
8. Shahin AY, Osman AM. Intraperitoneal lidocaine instillation and postcesarean pain after parietal peritoneal closure: a randomized double blind placebo-controlled trial. Clin J Pain 2010; 26: 121–127.
-
9. Perniola A, Magnuson A, Axelsson K, et al. Intraperitoneal local anesthetics have predominant local analgesic effect: a randomized, double-blind study. Anesthesiology 2014; 121: 352–361.
-
10. Perniola A, Fant F, Magnuson A, et al. Postoperative pain after abdominal hysterectomy: a randomized, double-blind, controlled trial comparing continuous infusion vs patient-controlled intraperitoneal injection of local anaesthetic. Br J Anaesth 2014; 112: 328–336.
-
11. Roy KK, Subbaiah M, Naha M, et al. Intraperitoneal bupivacaine for pain relief after minilaparoscopy in patients with infertility. Arch Gynecol Obstet 2014; 289: 337–340.
-
12. Arden D, Seifert E, Donnellan N, et al. Intraperitoneal instillation of bupivacaine for reduction of postoperative pain after laparoscopic hysterectomy: a double-blind randomized controlled trial. J Minim Invasive Gynecol 2013; 20: 620–626.
-
13. Coughlin SM, Karanicolas PJ, Emmerton-Coughlin HM, et al. Better late than never? Impact of local analgesia timing on postoperative pain in laparoscopic surgery: a systematic review and meta-analysis. Surg Endosc 2010; 24: 3167–3176.
-
14. Kahokehr A, Sammour T, Srinivasa S, et al. Systematic review and meta-analysis of intraperitoneal local anaesthetic for pain reduction after laparoscopic gastric procedures. Br J Surg 2011; 98: 29–36.
-
15. Kahokehr A, Sammour T, Soop M, et al. Intraperitoneal local anaesthetic in abdominal surgery—a systematic review. ANZ J Surg 2011; 81: 237–245.
-
16. Marks JL, Ata B, Tulandi T. Systematic review and meta-analysis of intraperitoneal instillation of local anesthetics for reduction of pain after gynecologic laparoscopy. J Minim Invasive Gynecol 2012; 19: 545–553.
-
17. Carpenter RE, Wilson DV, Evans AT. Evaluation of intraperitoneal and incisional lidocaine or bupivacaine for analgesia following ovariohysterectomy in the dog. Vet Anaesth Analg 2004; 31: 46–52.
-
18. Campagnol D, Teixeira-Neto FJ, Monteiro ER, et al. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaesth Analg 2012; 39: 426–430.
-
19. Kim YK, Lee SS, Suh EH, et al. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J 2012; 191: 188–192.
-
20. Mathews K, Kronen PW, Lascelles D, et al. Guidelines for recognition, assessment, and treatment of pain. J Small Anim Pract 2014; 55: E10–E68.
-
21. Lipscomb GH, Summitt RL Jr, McCord ML, et al. Serum bupivacaine levels during laparoscopic sterilization using local anesthesia. J Am Assoc Gynecol Laparosc 1994; 2: 27–30.
-
22. Narchi P, Benhamou D, Bouaziz H, et al. Serum concentrations of local anaesthetics following intraperitoneal administration during laparoscopy. Eur J Clin Pharmacol 1992; 42: 223–225.
-
23. Spielman FJ, Hulka JF, Ostheimer GW, et al. Pharmacokinetics and pharmacodynamics of local analgesia for laparoscopic tubal ligations. Am J Obstet Gynecol 1983; 146: 821–824.
-
24. Gaudette F, Benito J, Steagall P, et al. Assessment of tandem mass spectrometry and high-resolution mass spectrometry for the analysis of bupivacaine in plasma. Biomed Chromatogr 2015; 29: 1724–1730.
-
25. Rowland M, Tozer TN. Chapter 19. In: Rowland M, Tozer TN, eds. Clinical pharmacokinetics: concepts and applications. 3rd ed. Philadelphia: Lippincott, Williams & Wilkins, 1995:317–319.
-
26. de Jong RH, Ronfeld RA, DeRosa RA. Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics. Anesth Analg 1982; 61: 3–9.
-
27. Kasaba T, Shiraishi S, Taniguchi M. Bupivacaine-induced convulsion is suppressed by MK-801. Reg Anesth Pain Med 1998; 23: 71–76.
-
28. Chadwick HS. Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. Anesthesiology 1985; 63: 385–390.
-
29. Fuhrer Y, Charpentier C, Boulanger G, et al. Analgesia after laparoscopic cholecystectomy by intraperitoneal administration of bupivacaine [in French]. Ann Fr Anesth Reanim 1996; 15: 128–134.
-
30. Brocco MC, Paulo DN, Baptista JF, et al. Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis. Acta Cir Bras 2008; 23: 42–47.
-
31. Brocco MC, Paulo DN, Baptista JF, et al. Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal. Rev Bras Anestesiol 2008; 58: 470–479.
-
32. Camargo MG, Fagundes JJ, Leal RF, et al. Influence of the peritoneal lavage with bupivacaine on the survival and resistance of colonic anastomoses performed under fecal peritonitis in rats. Acta Cir Bras 2013; 28: 783–787.
-
33. Mather LE, Copeland SE, Ladd LA. Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Reg Anesth Pain Med 2005; 30: 553–566.
-
34. Shilo-Benjamini Y, Pascoe PJ, Maggs DJ, et al. Comparison of peribulbar and retrobulbar regional anesthesia with bupivacaine in cats. Am J Vet Res 2014; 75: 1029–1039.
-
35. Gupta PK, Hopkins PM. Effect of concentration of local anaesthetic solution on the ED50 of bupivacaine for supraclavicular brachial plexus block. Br J Anaesth 2013; 111: 293–296.
-
36. Tariq A, Abdulaziz AA. Effect of bupivacaine concentration on the efficacy of ultrasound-guided interscalene brachial plexus block. Saudi J Anaesth 2011; 5: 190–194.
-
37. Wilson DV, Barnes KS, Hauptman JG. Pharmacokinetics of combined intraperitoneal and incisional lidocaine in the dog following ovariohysterectomy. J Vet Pharmacol Ther 2004; 27: 105–109.
-
38. Scheinin B, Kellokumpu I, Lindgren L, et al. Effect of intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy. Acta Anaesthesiol Scand 1995; 39: 195–198.
Advertisement
Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy
Abstract
OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy.
ANIMALS 8 healthy cats.
PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0.25% bupivacaine) was injected into the peritoneal space over the right and left ovarian pedicles and caudal aspect of the uterus before ovariohysterectomy. Cats were monitored for signs of bupivacaine toxicosis. Venous blood samples (2 mL) were collected before (time 0) and 2, 5, 10, 15, 20, 30, 60, 120, and 240 minutes after bupivacaine administration. Plasma bupivacaine concentrations were determined with a liquid chromatography–tandem mass spectrometry method. Pharmacokinetic parameters were determined by data plotting followed by analysis with a noncompartmental model.
RESULTS No signs of bupivacaine toxicosis were observed. Maximum bupivacaine plasma concentration was 1,030 ± 497.5 ng/mL at a mean ± SD value of 30 ± 24 minutes after administration. Mean elimination half-life was 4.79 ± 2.7 hours. Mean clearance indexed by bioavailability and volume of distribution indexed by bioavailability were 0.35 ± 0.18 L•h/kg and 2.10 ± 0.84 L/kg, respectively.
CONCLUSIONS AND CLINICAL RELEVANCE Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis. Studies to investigate analgesic effects for this technique in cats are warranted.
Contributor Notes
Powered by PubFactory