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Evaluation of computed tomographic enterography with an orally administered lactulose solution in clinically normal dogs

Seoyeon Keh DVM, MS1, Jungmin Sohn DVM, MS2, Mihyun Choi DVM, MS3, Namsoon Lee DVM, MS4, Jaeyoung Jang DVM, MS5, Hyunwook Kim DVM, MS6, Dongwoo Chang DVM, PhD7, Mincheol Choi DVM, PhD8,9, and Junghee Yoon DVM, PhD10
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  • 1 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 2 College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul 151-472, Republic of Korea.
  • | 3 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 4 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 5 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 6 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 7 College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
  • | 8 Haemaru Referral Animal Hospital, Seongnam 463-050, Republic of Korea.
  • | 9 College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul 151-472, Republic of Korea.
  • | 10 College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul 151-472, Republic of Korea.

Abstract

OBJECTIVE To determine optimal techniques for CT enterography in clinically normal dogs and to evaluate luminal distention after oral administration of lactulose solution as a contrast agent.

ANIMALS 15 healthy dogs.

PROCEDURES CT was performed in a control group (2 dogs that underwent CT to evaluate metastasis and 5 other dogs). In a bolus administration group (5 dogs from the control group), lactulose solution (1.34 g/mL) was administered (60 mL/kg) rapidly via gastric tube to anesthetized dogs, and CT was performed every 10 minutes for 1 hour. In a continuous administration group of 8 other dogs, lactulose solution (60 mL/kg) was administered slowly via nasoesophageal tube over a period of 45 minutes. Then, 15 minutes after anesthetic induction, CT was performed every 10 minutes for 1 hour. Luminal distention of the small intestines was evaluated qualitatively by use of a 3-point scale.

RESULTS All small intestinal segments had poor luminal distention in the control group. The terminal ileum had poor luminal distention for the bolus administration group. Nearly all segments had good luminal distention for the continuous administration group with mild adverse effects. Luminal distention scores from 0 to 20 minutes after lactulose administration were significantly higher than scores from 30 to 60 minutes. Interobserver reproducibility was high for all intestinal segments.

CONCLUSIONS AND CLINICAL RELEVANCE CT performed between 0 and 20 minutes after continuous administration of lactulose solution (60 mL/kg) may reveal adequate luminal distention for examination of small intestinal segments in dogs.

Contributor Notes

Address correspondence to Dr. Yoon (heeyoon@snu.ac.kr).