Advertisement
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1. Brown C, King CE, Mossbarger S, et al. Flamingo taxon advisory group husbandry manual. Available at: aviansag.org/Husbandry/Unlocked/Care_Manuals/Flamingo%20Husbandry%20Guidelines.pdf. Accessed Jul 15, 2015.
-
2. Wyss FS, Wenker CJ. Phoenicopteriformes. In: Miller RE, Fowler ME, eds. Zoo and wild animal medicine: current therapy. 8th ed. St Louis: Saunders Elsevier, 2014; 105–112.
-
3. Nielsen AM, Nielsen SS, King CE, et al. Classification and prevalence of foot lesions in captive flamingos (Phoenicopteridae). J Zoo Wildl Med 2010; 41: 44–49.
-
4. Nielsen AM, Nielsen SS, King CE, et al. Risk factors for development of foot lesions in captive flamingos (Phoenicopteridae). J Zoo Wildl Med 2012: 43: 744–749.
-
5. Hawkins MG, Barron HW, Speer BL, et al. Birds. In: Carpenter JW, ed. Exotic animal formulary. 4th ed. St Louis: Elsevier Health Sciences, 2013; 277–281.
-
6. Papich MG, Messenger K. Nonsteroidal anti-inflammatory drugs. In: Grimm KA, Lamont LA, Tranquilli WJ, et al, eds. Lumb and Jones' veterinary anesthesia and analgesia. 5th ed. Ames, Iowa: Wiley Blackwell, 2015; 227–243
-
7. Pereira ME, Werther K. Evaluation of the renal effects of flunixin meglumine, ketoprofen and meloxicam in budgerigars (Melopsittacus undulatus). Vet Rec 2007; 160: 844–846.
-
8. Swarup D, Patra RC, Prakash V, et al. Safety of meloxicam to critically endangered Gyps vultures and other scavenging birds in India. Anim Conserv 2007; 21: 192–198.
-
9. Sinclair K, Paul-Murphy J, Church M, et al. Renal physiological and histopathological effects of meloxicam in Japanese quail (Coturnix japonica), in Proceedings. Annu Conf Assoc Avian Vet Assoc Exotic Mam Vet 2010; 287–288.
-
10. Dijkstra B, Sanchez-Migallon Guzman D, Gustavsen K, et al. Renal, gastrointestinal, and hemostatic effects of oral administration of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2015; 76: 308–317.
-
11. Montesinos A, Ardiaca M, Juan-Sallés C, et al. Effects of meloxicam on hematologic and plasma biochemical analyte values and results of histologic examination of kidney biopsy specimens of African grey parrots (Psittacus erithacus). J Avian Med Surg 2015; 29: 1–8.
-
12. Baert K, De Backer P. Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. J Vet Pharmacol Ther 2002; 25: 449–453
-
13. Cole GA, Paul-Murphy J, Krugner-Higby L, et al. Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis. Am J Vet Res 2009; 70: 1471–1476.
-
14. Molter CM, Cole GA, Gagnon DJ, et al. Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res 2013; 74: 375–380.
-
15. Lacasse C, Gamble KC, Boothe DM. Pharmacokinetics of a single dose of intravenous and oral meloxicam in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus). J Avian Med Surg 2013; 27: 204–210.
-
16. Baert K, De Backer P. Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comp Biochem Physiol C Toxicol Pharmacol 2003; 134: 25–33.
-
17. Naidoo V, Wolter K, Cromarty AD, et al. The pharmacokinetics of meloxicam in vultures. J Vet Pharmacol Ther 2008; 31: 128–134.
-
18. Wilson GH, Hernandez-Divers S, Budsberg SC, et al. Pharmacokinetics and use of meloxicam in psittacine birds, in Proceedings. 8th Eur Assoc Avian Vet Conf 2005; 230–231.
-
19. Ette EI, Williams PJ. Population pharmacokinetics I: background, concepts, and models. Ann Pharmacother 2004; 38: 1702–1706.
-
20. KuKanich B, Huff D, Riviere JE, et al. Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals. J Am Vet Med Assoc 2007; 230: 390–395.
-
21. Phillips BE, Harms CA, Lewbart GA, et al. Population pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in the green sea urchin (Strongylocentrotus droebachiensis) following intracoelomic and immersion administration. J Zoo Wildl Med 2016; 47;175–186.
-
22. Rosenberg JF, Haulena M, Brianne E, et al. Population pharmacokinetics of enrofloxacin in purple sea stars (Pisaster ochraceus) following an intracoelomic injection or extended immersion. Am J Vet Res 2016; 77: 1266–1275.
-
23. Chinnadurai SK, Messenger KM, Papich MG, et al. Meloxicam pharmacokinetics using nonlinear mixed-effects modeling in ferrets after single subcutaneous administration. J Vet Pharmacol Ther 2014; 37: 382–387.
-
24. Simeone CA, Nollens HH, Meegan JM, et al. Pharmacokinetics of single dose oral meloxicam in bottlenose dolphins (Tursiops truncatus). J Zoo Wildl Med 2014; 45: 594–599.
-
25. US Pharmacopeia. USP37-NF32. (1225) Validation of compendial procedures. Rockville, MD: US Pharmacopeial Convention, 2014.
-
26. ICH Expert Working Group. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. Validation of analytical procedures: text and methodology Q2(R1). Geneva: ICH, 2005.
-
27. Brune K. Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability. Curr Med Res Opin 2007; 23: 2985–2995.
Advertisement
Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)
Abstract
OBJECTIVE To determine the pharmacokinetics of a single dose of meloxicam after IM and oral administration to healthy lesser flamingos (Phoeniconaias minor) by use of a population approach.
ANIMALS 16 healthy captive lesser flamingos between 1 and 4 years of age.
PROCEDURES A single dose of meloxicam (0.5 mg/kg) was administered IM to each bird, and blood samples were collected from birds at 3 (n = 13 birds), 2 (2), or 1 (1) selected point between 0 and 13 hours after administration, with samples collected from birds at each point. After a 15-day washout period, the same dose of meloxicam was administered PO via a red rubber tube and blood samples were collected as described for IM administration. Pharmacokinetic values were determined from plasma concentrations measured by high-performance liquid chromatography.
RESULTS Plasma drug concentrations after IM administration of meloxicam reached a mean ± SD maximum value of 6.01 ± 3.38 μg/mL. Mean area under the concentration-versus-time curve was 17.78 ± 2.79 μg•h/mL, and mean elimination half-life was 1.93 ± 0.32 hours. Plasma concentrations after oral administration reached a mean maximum value of 1.79 ± 0.33 μg/mL. Mean area under the curve was 22.16 ± 7.17 μg•h/mL, and mean elimination half-life was 6.05 ± 3.53 hours.
CONCLUSIONS AND CLINICAL RELEVANCE In lesser flamingos, oral administration of meloxicam resulted in higher bioavailability and a longer elimination half-life than did IM administration, but the maximum plasma concentration was low and may be insufficient to provide analgesia in flamingos. Conversely, IM administration achieved the desired plasma concentration but would require more frequent administration.
Contributor Notes
Powered by PubFactory