• 1. Kyles AE, Hardie EM, Mehl M, et al. Evaluation of ameroid ring constrictors for the management of single extrahepatic portosystemic shunts in cats: 23 cases (1996–2001). J Am Vet Med Assoc 2002;220:13411347.

    • Search Google Scholar
    • Export Citation
  • 2. Leshem SS, Lotsikas PJ, Reimer B. In vitro expansion patterns of ameroid ring constrictors. Am J Vet Res 2008;69:15201524.

  • 3. Tobias KM, Rohrbach BW. Association of breed with the diagnosis of congenital portosystemic shunts in dogs: 2,400 cases (1980–2002). J Am Vet Med Assoc 2003;223:16361639.

    • Search Google Scholar
    • Export Citation
  • 4. Adin CA, Sereda CW, Thompson MS, et al. Outcome associated with use of a percutaneously controlled hydraulic occluder for treatment of dogs with intrahepatic portosystemic shunts. J Am Vet Med Assoc 2006;229:17491755.

    • Search Google Scholar
    • Export Citation
  • 5. Johnson CA, Armstrong PJ, Hauptman JG. Congenital portosystemic shunts in dogs: 46 cases (1979–1986). J Am Vet Med Assoc 1987;191:14781483.

    • Search Google Scholar
    • Export Citation
  • 6. Hottinger HA, Walshaw R, Hauptman JG. Long-term results of complete and partial ligation of congenital portosystemic shunts in dogs. Vet Surg 1995;24:331336.

    • Search Google Scholar
    • Export Citation
  • 7. Greenhalgh SN, Dunning MD, McKinley TJ, et al. Comparison of survival after surgical or medical treatment in dogs with a congenital portosystemic shunt. J Am Vet Med Assoc 2010;236:12151220.

    • Search Google Scholar
    • Export Citation
  • 8. Frankel D, Seim H, MacPhail C, et al. Evaluation of cellophane banding with and without intraoperative attenuation for treatment of congenital extrahepatic portosystemic shunts in dogs. J Am Vet Med Assoc 2006;228:13551360.

    • Search Google Scholar
    • Export Citation
  • 9. Smith KR, Bauer M, Monnet E. Portosystemic communications: follow-up of 32 cases. J Small Anim Pract 1995;36:435440.

  • 10. Bright SR, Williams JM, Niles JD. Outcomes of intrahepatic portosystemic shunts occluded with ameroid constrictors in nine dogs and one cat. Vet Surg 2006;35:300309.

    • Search Google Scholar
    • Export Citation
  • 11. Youmans KR, Hunt GB. Experimental evaluation of four methods of progressive venous attenuation in dogs. Vet Surg 1999;28:3847.

  • 12. Léveillé R, Johnson SE, Birchard SJ. Transvenous coil embolization of portosystemic shunt in dogs. Vet Radiol Ultrasound 2003;44:3236.

    • Search Google Scholar
    • Export Citation
  • 13. Sereda CW, Adin CA. Methods of gradual vascular occlusion and their applications in treatment of congenital portosystemic shunts in dogs: a review. Vet Surg 2005;34:8391.

    • Search Google Scholar
    • Export Citation
  • 14. Hunt GB, Kummeling A, Tisdall PLC, et al. Outcomes of cellophane banding for congenital portosystemic shunts in 106 dogs and 5 cats. Vet Surg 2004;33:2531.

    • Search Google Scholar
    • Export Citation
  • 15. Vogt JC, Krahwinkel DJ, Bright RM, et al. Gradual occlusion of extrahepatic portosystemic shunts in dogs and cats using the ameroid constrictor. Vet Surg 1996;25:495502.

    • Search Google Scholar
    • Export Citation
  • 16. Mehl ML, Kyles AE, Hardie EM, et al. Evaluation of ameroid ring constrictors for the treatment for single extrahepatic portosystemic shunts in dogs: 168 cases (1995–2001). J Am Vet Med Assoc 2005;226:20202030.

    • Search Google Scholar
    • Export Citation
  • 17. Adin CA, Gregory CR, Kyles AE, et al. Effect of petrolatum coating on the rate of occlusion of ameroid constrictors in the peritoneal cavity. Vet Surg 2004;33:1116.

    • Search Google Scholar
    • Export Citation
  • 18. Beliciu CM, Sauer A, Moraru CI. The effect of commercial sterilization regimens on micellar casein concentrates. J Dairy Sci 2012;95:55105526.

    • Search Google Scholar
    • Export Citation
  • 19. Lange PE, Seivers HH, Nurnberg JH, et al. A new device for slow progressive narrowing of vessels. Basic Res Cardiol 1985;80:430435.

  • 20. Besancon MF, Kyles AE, Griffey SM, et al. Evaluation of the characteristics of venous occlusion after placement of an ameroid ring constrictor in dogs. Vet Surg 2004;33:597605.

    • Search Google Scholar
    • Export Citation
  • 21. Elzinga WE. Ameroid constrictor: uniform closure rates and a calibration procedure. J Appl Physiol 1969;27:419421.

  • 22. Monnet E, Rosenberg A. Effect of protein concentration on rate of closure of ameroid constrictors in vitro. Am J Vet Res 2005;66:13371340.

    • Search Google Scholar
    • Export Citation
  • 23. Murphy ST, Ellison GW, Long M, et al. A comparison of the ameroid constrictor versus ligation in the surgical management of single extrahepatic portosystemic shunts. J Am Anim Hosp Assoc 2001;37:390396.

    • Search Google Scholar
    • Export Citation

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In vitro effect of multiple hydrogen peroxide gas plasma sterilizations on the rate of closure of ameroid constrictors

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  • 1 Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
  • | 2 Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
  • | 3 Departments of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
  • | 4 Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Abstract

Objective—To evaluate the effect of multiple hydrogen peroxide gas plasma (HPGP) sterilizations on the rate of closure of ameroid constrictors.

Sample—Thirty-six 5.0-mm ameroid constrictors.

Procedures—Ameroid constrictors were randomly allocated to 6 groups. Each group underwent 1, 2, 3, 4, 5, or 6 HPGP sterilizations. Ameroid constrictors were then incubated for 35 days in canine plasma and digitally imaged at predetermined times during incubation. One individual, who was unaware of the group to which each ameroid constrictor was assigned, measured the lumen area of the constrictor on each digital image. Mean lumen area was compared among groups.

Results—No ameroid constrictors were completely closed after 35 days of incubation in canine plasma. Mean lumen area after incubation did not differ among constrictors that underwent 1, 2, and 3 sterilizations. Constrictors that underwent 4 sterilizations were closed significantly more than were those that underwent 1, 2, or 3 sterilizations. Mean lumen area after incubation did not differ significantly between constrictors that underwent 5 and 6 sterilizations, although the final lumen areas for those constrictors were significantly smaller than those for constrictors that underwent 1, 2, 3, and 4 sterilizations.

Conclusions and Clinical Relevance—Ameroid constrictors that underwent 5 and 6 HPGP sterilizations had a 9% to 12% decrease in lumen area, compared with that of constrictors that underwent ≤ 4 plasma sterilizations, and the use of such constrictors could increase the risk of portal hypertension and secondary acquired shunting or decrease the risk of persistent shunting.

Contributor Notes

The authors thank Drs. Gary Lantz and Ralph Millard for technical assistance.

The authors had no affiliations with any vendors of materials used in the study.

Address correspondence to Dr. Towle Millard (millardh@purdue.edu).