• 1. McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 2012; 33: 17871847.

    • Search Google Scholar
    • Export Citation
  • 2. Kjaergaard J, Petersen CL, Kjaer A, et al. Evaluation of right ventricular volume and function by 2D and 3D echocardiography compared to MRI. Eur J Echocardiogr 2006; 7: 430438.

    • Search Google Scholar
    • Export Citation
  • 3. Gilbert SH, McConnell FJ, Holden AV, et al. The potential role of MRI in veterinary clinical cardiology Vet J 2010; 183: 124134.

  • 4. Contreras S, Vazquez JM, Miguel AD, et al. Magnetic resonance angiography of the normal canine heart and associated blood vessels. Vet J 2008; 178: 130132.

    • Search Google Scholar
    • Export Citation
  • 5. Mai W, Weisse C, Sleeper MM. Cardiac magnetic resonance imaging in normal dogs and two dogs with heart base tumor. Vet Radiol Ultrasound 2010; 51: 428435.

    • Search Google Scholar
    • Export Citation
  • 6. Sugeng L, Mor-Avi V, Weinert L, et al. Quantitative assessment of left ventricular size and function: side-by-side comparison of real-time three-dimensional echocardiography and computed tomography with magnetic resonance reference. Circulation 2006; 114: 654661.

    • Search Google Scholar
    • Export Citation
  • 7. Mahnken AH, Spuentrup E, Niethammer M, et al. Quantitative and qualitative assessment of left ventricular volume with ECG-gated multislice spiral CT: value of different image reconstruction algorithms in comparison to MRI. Acta Radiol 2003; 44: 604611.

    • Search Google Scholar
    • Export Citation
  • 8. Greupner J, Zimmermann E, Grohmann A, et al. Head-to-head comparison of left ventricular function assessment with 64-row computed tomography, biplane left cineventriculography, and both 2- and 3-dimensional transthoracic echocardiography: comparison with magnetic resonance imaging as the reference standard [Erratum published in J Am Coll Cardiol 2012; 60:481]. J Am Coll Cardiol 2012; 59: 18971907.

    • Search Google Scholar
    • Export Citation
  • 9. Dell'Italia LJ, Blackwell GG, Pearce DJ, et al. Assessment of ventricular volumes using cine magnetic resonance in the intact dog. A comparison of measurement methods. Invest Radiol 1994; 29: 162167.

    • Search Google Scholar
    • Export Citation
  • 10. Markiewicz W, Sechtem U, Kirby R, et al. Measurement of ventricular volumes in the dog by nuclear magnetic resonance imaging. J Am Coll Cardiol 1987; 10: 170177.

    • Search Google Scholar
    • Export Citation
  • 11. Hockings PD, Busza AL, Byrne J, et al. Validation of MRI measurement of cardiac output in the dog: the effects of dobutamine and minoxidil. Toxicol Mech Methods 2003; 13: 3943.

    • Search Google Scholar
    • Export Citation
  • 12. Henjes CR, Nolte I, Wefstaedt P. Multidetector-row computed tomography of thoracic aortic anomalies in dogs and cats: patent ductus arteriosus and vascular rings. BMC Vet Res 2011; 7:57.

    • Search Google Scholar
    • Export Citation
  • 13. Henjes CR, Hungerbuehler S, Bojarski IB, et al. Comparison of multi-detector row computed tomography with echocardiography for assessment of left ventricular function in healthy dogs. Am J Vet Res 2012; 73: 393403.

    • Search Google Scholar
    • Export Citation
  • 14. Ljungvall I, Hoglund K, Carnabuci C, et al. Assessment of global and regional left ventricular volume and shape by real-time 3-dimensional echocardiography in dogs with myxomatous mitral valve disease. J Vet Intern Med 2011; 25: 10361043.

    • Search Google Scholar
    • Export Citation
  • 15. Tidholm A, Haeggstrom J, Borgarelli M, et al. Canine idiopathic dilated cardiomyopathy. Part I: aetiology, clinical characteristics, epidemiology and pathology. Vet J 2001; 162: 92107.

    • Search Google Scholar
    • Export Citation
  • 16. Hergan K, Schuster A, Frühwald J, et al. Comparison of left and right ventricular volume measurement using the Simpson's method and the area length method. Eur J Radiol 2008; 65: 270278.

    • Search Google Scholar
    • Export Citation
  • 17. Kraetschmer S, Ludwig K, Meneses F, et al. Vertebral heart scale in the Beagle dog. J Small Anim Pract 2008; 49: 240243.

  • 18. Maffei E, Messalli G, Martini C, et al. Left and right ventricle assessment with cardiac CT: validation study vs. cardiac MR. Eur Radiol 2012; 22: 10411049.

    • Search Google Scholar
    • Export Citation
  • 19. Boese JM, Bahner ML, Albers J, et al. Optimizing temporal resolution in CT with retrospective ECG gating [in German]. Radiologe 2000; 40: 123129.

    • Search Google Scholar
    • Export Citation
  • 20. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1: 307310.

    • Search Google Scholar
    • Export Citation
  • 21. Brodoefel H, Kramer U, Reimann A, et al. Dual-source CT with improved temporal resolution in assessment of left ventricular function: a pilot study. AJR Am J Roentgenol 2007; 189: 10641070.

    • Search Google Scholar
    • Export Citation
  • 22. Heuschmid M, Rothfuss J, Schroder S, et al. Left ventricular functional parameters: comparison of 16-slice spiral CT with MRI [in German]. Rofo 2005; 177: 6066.

    • Search Google Scholar
    • Export Citation
  • 23. Mahnken AH, Spuntrup E, Wildberger JE, et al. Quantification of cardiac function with multislice spiral CT using retrospective EKG-gating: comparison with MRI [in German]. Rofo 2003; 175: 8388.

    • Search Google Scholar
    • Export Citation
  • 24. Wess G, Maurer J, Simak J, et al. Use of Simpson's method of disc to detect early echocardiographic changes in Doberman Pinschers with dilated cardiomyopathy. J Vet Intern Med 2010; 24: 10691076.

    • Search Google Scholar
    • Export Citation
  • 25. Boon JA. Dilated cardiomyopathy. In: Boon JA, ed. Veterinary echocardiography. Ames, Iowa: Wiley-Blackwell, 2011;381396.

  • 26. Kudelka AM, Turner DA, Liebson PR, et al. Comparison of cine magnetic resonance imaging and Doppler echocardiography for evaluation of left ventricular diastolic function. Am J Cardiol 1997; 80: 384386.

    • Search Google Scholar
    • Export Citation
  • 27. MacDonald KA, Kittleson MD, Garcia-Nolen T, et al. Tissue Doppler imaging and gradient echo cardiac magnetic resonance imaging in normal cats and cats with hypertrophic cardiomyopathy. J Vet Intern Med 2006; 20: 627634.

    • Search Google Scholar
    • Export Citation
  • 28. Jacobs G, Mahjoob K. Influence of alterations in heart rate on echocardiographic measurements in the dog. Am J Vet Res 1988; 49: 548552.

    • Search Google Scholar
    • Export Citation
  • 29. Mahnken AH, Hohl C, Suess C, et al. Influence of heart rate and temporal resolution on left-ventricular volumes in cardiac multislice spiral computed tomography: a phantom study. Invest Radiol 2006; 41: 429435.

    • Search Google Scholar
    • Export Citation
  • 30. Juergens KU, Grude M, Maintz D, et al. Multi-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience. Radiology 2004; 230: 403410.

    • Search Google Scholar
    • Export Citation
  • 31. Primak AN, McCollough CH, Bruesewitz MR, et al. Relationship between noise, dose, and pitch in cardiac multi-detector row CT. Radiographics 2006; 26: 17851794.

    • Search Google Scholar
    • Export Citation
  • 32. Ohnesorge B, Flohr T, Becker C, et al. Cardiac imaging with rapid, retrospective ECG synchronized multilevel spiral CT [in German]. Radiologe 2000; 40: 111117.

    • Search Google Scholar
    • Export Citation
  • 33. Mahnken AH, Gunther RW, Krombach GA. The basics of left ventricular functional analysis with MRI and MSCT [in German]. Rofo 2004; 176: 13651379.

    • Search Google Scholar
    • Export Citation
  • 34. Juergens KU, Maintz D, Grude M, et al. Multi-detector row computed tomography of the heart: does a multi-segment reconstruction algorithm improve left ventricular volume measurements? Eur Radiol 2005; 15: 111117.

    • Search Google Scholar
    • Export Citation
  • 35. Miller S, Simonetti OP, Carr J, et al. MR imaging of the heart with cine true fast imaging with steady-state precession: influence of spatial and temporal resolutions on left ventricular functional parameters. Radiology 2002; 223: 263269.

    • Search Google Scholar
    • Export Citation
  • 36. Koch K, Oellig F, Oberholzer K, et al. Assessment of right ventricular function by 16-detector-row CT: comparison with magnetic resonance imaging. Eur Radiol 2005; 15: 312318.

    • Search Google Scholar
    • Export Citation
  • 37. Takx RA, Moscariello A, Schoepf UJ, et al. Quantification of left and right ventricular function and myocardial mass: comparison of low-radiation dose 2nd generation dual-source CT and cardiac MRI. Eur J Radiol 2012; 81: e598e604.

    • Search Google Scholar
    • Export Citation
  • 38. Schalla S, Nagel E, Lehmkuhl H, et al. Comparison of magnetic resonance real-time imaging of left ventricular function with conventional magnetic resonance imaging and echocardiography. Am J Cardiol 2001; 87: 9599.

    • Search Google Scholar
    • Export Citation
  • 39. Cui W, Kondo T, Anno H, et al. The accuracy and optimal slice thickness of multislice helical computed tomography for right and left ventricular volume measurement. Chin Med J (Engl) 2004; 117: 12831287.

    • Search Google Scholar
    • Export Citation

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Comparative assessment of left ventricular function variables determined via cardiac computed tomography and cardiac magnetic resonance imaging in dogs

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  • 1 Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • | 2 Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • | 3 Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
  • | 4 Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.

Abstract

Objective—To evaluate the accuracy and reproducibility of left ventricular (LV) volumetric and function variables determined via contrast-enhanced cardiac CT and cardiac MRI in healthy dogs.

Animals—10 healthy Beagles.

Procedures—Cardiac MRI and cardiac CT were performed in anesthetized Beagles; both examinations were conducted within a 2-hour period. Cardiac MRI was performed with a 3.0-T magnet, and contrast-enhanced cardiac CT was performed with a 64-row detector CT machine. Data sets were acquired during apnea with simultaneous ECG gating. Short-axis images were created to determine functional variables via the Simpson method.

Results—Cardiac CT values for mean end-diastolic and end-systolic LV volumes had excellent correlation (r = 0.95) with cardiac MRI measurements, whereas LV stroke volume (r = 0.67) and LV ejection fraction (r = 0.75) had good correlations. The only variable that differed significantly between imaging modalities was end-diastolic LV volume. For each pair of values, Bland-Altman analysis revealed good limits of agreement.

Conclusions and Clinical Relevance—The 3-D modalities cardiac CT and cardiac MRI were excellent techniques for use in assessing LV functional variables. Similar results were obtained for LV volume and function variables via both techniques. The major disadvantage of these modalities was the need to anesthetize the dogs for the examinations.

Contributor Notes

Address correspondence to Dr. Nolte (ingo.nolte@tiho-hannover.de).