Editorial Type:
Cardiovascular System

Comparison of echocardiography with dual-source computed tomography for assessment of left ventricular volume in healthy Beagles

Miyoung Lee Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Nohwon Park Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Seungyeon Lee Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Ahra Lee Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Joohyun Jung Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Youngjun Kim Department of Radiology, College of Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Sungmin Ko Department of Radiology, College of Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Hwiyool Kim Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Soonwuk Jeong Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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Kidong Eom Departments of Veterinary Radiology and Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.

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DOI:
https://doi.org/10.2460/ajvr.74.1.62
Volume/Issue:
Volume 74: Issue 1
Online Publication Date:
01 Jan 2013
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Abstract

Objective—To compare echocardiographic measurements of left ventricular (LV) volume obtained via a modified Simpson or Teichholz method with those obtained via dual-source CT (DSCT).

Animals—7 healthy Beagles.

Procedures—Each dog was anesthetized for DSCT; LV volume was determined from contrast-enhanced images of the LV lumen during all phases of contraction. Echocardiography was performed with dogs awake and anesthetized. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume, and ejection fraction were measured via a modified Simpson method and Teichholz method. Each dog was anesthetized twice with a 1-week interval between anesthetic sessions.

Results—Results obtained while dogs were anesthetized revealed that the modified Simpson method underestimated LV volume (mean ± SD EDV, 24.82 ± 2.38 mL; ESV, 12.24 ± 1.77 mL), compared with that estimated by the Teichholz method (EDV, 32.57 ± 2.85 mL; ESV, 14.87 ± 2.09 mL) or DSCT (EDV, 34.14 ± 1.57 mL; ESV, 16.71 ± 0.76 mL). Ejection fraction (modified Simpson method, 48.53% ± 4.24%; Teichholz method, 54.33% ± 4.26%; DSCT, 51.00% ± 2.71%) differed significantly among the 3 methods. Echocardiographic results obtained while dogs were awake revealed that EDV, ESV, and stroke volume differed significantly between the modified Simpson and Teichholz methods.

Conclusions and Clinical Relevance—LV volume determined via the Teichholz method was more similar to that determined via DSCT than was the LV volume determined via the modified Simpson method. The modified Simpson method underestimated LV volume, compared with that obtained via the Teichholz method, in both anesthetized and awake dogs.

Abstract

Objective—To compare echocardiographic measurements of left ventricular (LV) volume obtained via a modified Simpson or Teichholz method with those obtained via dual-source CT (DSCT).

Animals—7 healthy Beagles.

Procedures—Each dog was anesthetized for DSCT; LV volume was determined from contrast-enhanced images of the LV lumen during all phases of contraction. Echocardiography was performed with dogs awake and anesthetized. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume, and ejection fraction were measured via a modified Simpson method and Teichholz method. Each dog was anesthetized twice with a 1-week interval between anesthetic sessions.

Results—Results obtained while dogs were anesthetized revealed that the modified Simpson method underestimated LV volume (mean ± SD EDV, 24.82 ± 2.38 mL; ESV, 12.24 ± 1.77 mL), compared with that estimated by the Teichholz method (EDV, 32.57 ± 2.85 mL; ESV, 14.87 ± 2.09 mL) or DSCT (EDV, 34.14 ± 1.57 mL; ESV, 16.71 ± 0.76 mL). Ejection fraction (modified Simpson method, 48.53% ± 4.24%; Teichholz method, 54.33% ± 4.26%; DSCT, 51.00% ± 2.71%) differed significantly among the 3 methods. Echocardiographic results obtained while dogs were awake revealed that EDV, ESV, and stroke volume differed significantly between the modified Simpson and Teichholz methods.

Conclusions and Clinical Relevance—LV volume determined via the Teichholz method was more similar to that determined via DSCT than was the LV volume determined via the modified Simpson method. The modified Simpson method underestimated LV volume, compared with that obtained via the Teichholz method, in both anesthetized and awake dogs.

Contributor Notes

This study was supported by Konkuk University in 2012.

Address correspondence to Dr. Eom (eomkd@konkuk.ac.kr).
Cover American Journal of Veterinary Research
American Journal of Veterinary Research
Publication Date:
01 Jan 2013
  • 1.

    Katz AM. Physiology of the heart. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2001; 418–450.

  • 2.

    Bellenger NG, Burgess MI, Ray SG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J 2000; 21: 1387–1396.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Annuar BR, Liew CK, Chin SP, et al. Assessment of global and regional left ventricular function using 64-slice multislice computed tomography and 2D echocardiography: a comparison with cardiac magnetic resonance. Eur J Radiol 2008; 65: 112–119.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Chang S, Chou H, Liang H, et al. Quantification of left ventricular volumes using three-dimensional echocardiography: comparison with 64-slice multidetector computed tomography. J Med Ultrasound 2010; 18: 71–78.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Jacobs LD, Salgo IS, Goonewardena S, et al. Rapid online quantification of left ventricular volume from real-time three-dimensional echocardiographic data. Eur Heart J 2006; 27: 460–468.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Kim SS, Ko SM, Song MG, et al. Assessment of global function of left ventricle with dual-source CT in patients with severe arrhythmia: a comparison with the use of two-dimensional transthoracic echocardiography. Int J Cardiovasc Imaging 2010; 26: 213–221.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Stolzmann P, Scheffel H, Trindade PT, et al. Left ventricular and left atrial dimensions and volumes: comparison between dual-source CT and echocardiography. Invest Radiol 2008; 43: 284–289.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Schiller NB. Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography. Circulation 1991; 84:I280–I287.

    • Search Google Scholar
    • Export Citation
  • 9.

    Boon JA. Veterinary echocardiography. 2nd ed. Hoboken, NJ: Wiley-Blackwell, 2011; 198–224.

  • 10.

    Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440–1463.

    • Search Google Scholar
    • Export Citation
  • 11.

    Juergens KU, Seifarth H, Range F, et al. Automated threshold-based 3D segmentation versus short-axis planimetry for assessment of global left ventricular function with dual-source MDCT. AJR Am J Roentgenol 2008; 190: 308–314.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Mahnken AH, Mühlenbruch G, Günther RW, et al. Cardiac CT: coronary arteries and beyond. Eur Radiol 2007; 17: 994–1008.

  • 13.

    Orakzai SH, Orakzai RH, Nasir K, et al. Assessment of cardiac function using multidetector row computed tomography. J Comput Assist Tomogr 2006; 30: 555–563.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Lynch M, Ghita O, Whelan PF. Automatic segmentation of the left ventricle cavity and myocardium in MRI data. Comput Biol Med 2006; 36: 389–407.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Mahnken AH, Koos R, Katoh M, et al. Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction. Eur Radiol 2005; 15: 714–720.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Achenbach S, Ropers D, Kuettner A, et al. Contrast-enhanced coronary artery visualization by dual-source computed tomography—initial experience. Eur J Radiol 2006; 57: 331–335.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Johnson TR, Nikolaou K, Wintersperger BJ, et al. Dual-source CT cardiac imaging: initial experience. Eur Radiol 2006; 16: 1409–1415.

  • 18.

    Groen JM, van der Vleuten PA, Greuter MJW, et al. Comparison of MRI, 64-slice MDCT and DSCT in assessing functional cardiac parameters of a moving heart phantom. Eur Radiol 2009; 19: 577–583.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19.

    Mahnken AH, Bruder H, Suess C, et al. Dual-source computed tomography for assessing cardiac function: a phantom study. Invest Radiol 2007; 42: 491–498.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    Brodoefel H, Kramer U, Reimann A, et al. Dual-source CT with improved temporal resolution in assessment of left ventricular function: a pilot study. AJR Am J Roentgenol 2007; 189: 1064–1070.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Mao S, Takasu J, Child J, et al. Comparison of LV mass and volume measurements derived from electron beam tomography using cine imaging and angiographic imaging. Int J Cardiovasc Imaging 2003; 19: 439–445.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22.

    Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358–367.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Boon JA. Manual of veterinary echocardiography. Ames, Iowa: Blackwell, 2006; 186–209.

  • 24.

    Teichholz LE, Kreulen T, Herman MV, et al. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence or absence of asynergy. Am J Cardiol 1976; 37: 7–11.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25.

    Kronik G, Slany J, Mösslacher H. Comparative value of eight M-mode echocardiographic formulas for determining left ventricular stroke volume. A correlative study with thermodilution and left ventricular single-plane cineangiography. Circulation 1979; 60: 1308–1316.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26.

    Uehara Y, Koga M, Takahashi M. Determination of cardiac output by echocardiography. J Vet Med Sci 1995; 57: 401–407.

  • 27.

    Sisson DD, Daniel GB, Twardock AR. Comparison of left ventricular ejection fractions determined in healthy anesthetized dogs by echocardiography and gated equilibrium radionuclide ventriculography. Am J Vet Res 1989; 50: 1840–1847.

    • Search Google Scholar
    • Export Citation
  • 28.

    Juergens KU, Fischbach R. Left ventricular function studied with MDCT. Eur Radiol 2006; 16: 342–357.

  • 29.

    Serres F, Chetboul V, Tissier R, et al. Comparison of 3 ultrasound methods for quantifying left ventricular systolic function: correlation with disease severity and prognostic value in dogs with mitral valve disease. J Vet Intern Med 2008; 22: 566–577.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30.

    Tidholm A, Westling AB, Höglund K, at el. Comparison of 3-, 2-dimensional, and M-mode echocardiographical methods for estimation of left chamber volumes in dogs with and without acquired heart disease. J Vet Intern Med 2010; 24: 1414–1420.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31.

    Ahmad M, Xie T, McCulloch M, et al. Real-time three-dimensional dobutamine stress echocardiography in assessment of ischemia: comparison with two-dimensional dobutamine stress echocardiography. J Am Coll Cardiol 2001; 37: 1303–1309.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32.

    Gopal AS, Keller AM, Rigling R, et al. Left ventricular volume and endocardial surface area by three-dimensional echocardiography: comparison with two-dimensional echocardiography and nuclear magnetic resonance imaging in normal subjects. J Am Coll Cardiol 1993; 22: 258–270.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 33.

    Gutiérrez-Chico JL, Zamorano JL, Pérez de Isla L, et al. Comparison of left ventricular volumes and ejection fractions measured by three-dimensional echocardiography versus by two-dimensional echocardiography and cardiac magnetic resonance in patients with various cardiomyopathies. Am J Cardiol 2005; 95: 809–813.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34.

    Mochizuki T, Murase K, Higashino H. Two- and three-dimensional CT ventriculography: a new application of helical CT. AJR Am J Roentgenol 2000; 174: 203–208.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 35.

    Vainio O. Introduction to the clinical pharmacology of medetomidine. Acta Vet Scand Suppl 1989;(85):85–88.

  • 36.

    Pypendop B, Verstegen J. A comparison of the sedative and analgesic effects of buprenorphine in combination with acepromazine, midazolam or medetomidine in dogs. Vet Anaesth Analg 1994; 21: 15–20.

    • Search Google Scholar
    • Export Citation
  • 37.

    Savola JM. Cardiovascular actions of medetomidine and their reversal by atipamezole. Acta Vet Scand Suppl 1989;(85):39–47.

  • 38.

    Muir WW, Piper FS. Effect of xylazine on indices of myocardial contractility in the dog. Am J Vet Res 1977; 38: 931–934.

  • 39.

    Pypendop B, Serteyn D, Verstegen J. Hemodynamic effects of medetomidine-midazolam-butorphanol and medetomidine-midazolam-buprenorphine combinations and reversibility by atipamezole in dogs. Am J Vet Res 1996; 57: 724–730.

    • Search Google Scholar
    • Export Citation
  • 40.

    Haskins SC, Patz JD, Farver TB. Xylazine and xylazine-ketamine in dogs. Am J Vet Res 1986; 47: 636–641.

  • 41.

    Serteyn D, Coppens P, Jones R, et al. Circulatory and respiratory effects of the combination medetomidine-ketamine in Beagles. J Vet Pharmacol Ther 1993; 16: 199–206.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 42.

    Alfakih K, Reid S, Jones T, et al. Assessment of ventricular function and mass by cardiac magnetic resonance imaging. Eur Radiol 2004; 14: 1813–1822.

    • Search Google Scholar
    • Export Citation
  • 43.

    Rerkpattanapipat P, Mazur W, Link KM, et al. Assessment of cardiac function with MR imaging. Magn Reson Imaging Clin N Am 2003; 11: 67–80.

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