Impacts of dual-use research on life science researchers including veterinarians

Tanya D. Graham Veterinary and Biomedical Sciences Department, College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007.

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 DVM, DACVP

Abstract

Since the September 11, 2001, terrorist attacks, concern for the future direction of biological research has expanded to include not only issues involving the welfare of mankind, but also the more immediate and personal concern of individual scientists in the life sciences community. For many investigators in the life sciences, the remainder of their careers will be impacted by concerns about bioterrorism and issues associated with dual-use research. Awareness of these issues will be critical for all professional groups and affiliated organizations as they navigate the growing call for more federal rules and regulations. Veterinarians are not immune to the coming changes in science; all researchers risk criminal sanctions if they violate the USA Patriot Act or the Bioterrorism Act of 2002. Compliance with these regulations will be necessary, not just because of the potential legal ramifications, but because establishing and maintaining public trust is a never-ending requirement for the future of scientific research.

Abstract

Since the September 11, 2001, terrorist attacks, concern for the future direction of biological research has expanded to include not only issues involving the welfare of mankind, but also the more immediate and personal concern of individual scientists in the life sciences community. For many investigators in the life sciences, the remainder of their careers will be impacted by concerns about bioterrorism and issues associated with dual-use research. Awareness of these issues will be critical for all professional groups and affiliated organizations as they navigate the growing call for more federal rules and regulations. Veterinarians are not immune to the coming changes in science; all researchers risk criminal sanctions if they violate the USA Patriot Act or the Bioterrorism Act of 2002. Compliance with these regulations will be necessary, not just because of the potential legal ramifications, but because establishing and maintaining public trust is a never-ending requirement for the future of scientific research.

Contributor Notes

Presented as a poster at the 54th Annual American Association of Veterinary Laboratory Diagnosticians, Buffalo, NY, September–October 2011.

The author does not have any financial or personal relationships that could inappropriately influence or bias the content of the paper.

Address correspondence to Dr. Graham (tanya.graham@sdstate.edu).
  • 1.

    Shea D. CRC report for congress. Oversight of dual-use biological research: the National Science Advisory Board for Biosecurity. Washington, DC: Congressional Research Service, 2007. Available at: www.fas.org/sgp/crs/natsec/RL33342.pdf. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation
  • 2.

    National Institutes of Health, Office of Biotechnology Activities. About NSABB. Available at: oba.od.nih.gov/biosecurity/about_nsabb.html. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation
  • 3.

    NSABB. Proposed framework for the oversight of dual use life sciences research: strategies for minimizing the potential misuse of research information. Washington, DC: NIH Office of Biotechnology Activities, 2007. Available at: oba.od.nih.gov/biosecurity/pdf/Framework%20for%20transmittal%200807_Sept07.pdf. Accessed Feb 18, 2011.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Heinrich J. Testimony before the Subcommittee on Oversight and Investigations, Committee on Energy and Commerce, House of Representatives. Homeland security: new department could improve biomedical R&D coordination but may disrupt dual-purpose efforts. Publication No. GAO-02-924T. Washington, DC: US Government Accountability Office, 2002. Available at: www.gao.gov/new.items/d02924t.pdf. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation
  • 5.

    NIH Office of Biotechnology Activities. NIH guidelines for research involving recombinant dna molecules. Available at: http://oba.od.nih.gov/rdna/nih_guidelines_oba.html. Accessed Aug 31, 2012.

    • Search Google Scholar
    • Export Citation
  • 6.

    National Research Council Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology. Biotechnology research in an age of terrorism: confronting the dual use dilemma. Washington, DC: National Research Council, 2004. Available at: www.nap.edu/openbook.php?isbn=0309089778. Accessed Feb 18, 2011.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Atlas R. Biosecurity concerns: changing the face of academic research. J Chem Health Saf 2005; 12: 15–23.

  • 8.

    Russell CAFonville JMBrown AE, et al. The potential for respiratory droplet-transmission A/H5N1 influenza virus to evolve in a mammalian host. Science 2012; 336: 1541–1547.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Herfst SSchrauwen EJLinster M, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012; 336: 1534–1541.

    • Search Google Scholar
    • Export Citation
  • 10.

    Roos R. 2012. Research on contagious H5N1 viruses: space suits needed? CIDRAP News. Available at: www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/mar0612biosafety.html. Accessed Mar 23, 2012.

    • Search Google Scholar
    • Export Citation
  • 11.

    National Institutes of Health. Statement by NIH Director Francis Collins M.D., Ph.D on the NSABB review of revised H5N1 manuscripts. Available at: www.nih.gov/about/director/04202012_NSABB.htm. Accessed May 7, 2012.

    • Search Google Scholar
    • Export Citation
  • 12.

    National Security Council. National strategy for countering biological threats. Washington, DC: The White House, 2009. Available at: www.whitehouse.gov/sites/default/files/National_Strategy_for_Countering_BioThreats.pdf. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation
  • 13.

    NIH Office of Biotechnology Activities. United States government policy for oversight of life sciences dual use research of concern. Available at: oba.od.nih.gov/oba/biosecurity/PDF/United_States_Government_Policy_for_Oversight_of_DURC_FINAL_version_032812.pdf. Accessed May 7, 2012.

    • Crossref
    • Export Citation
  • 14.

    NSABB Working Group on International Engagement. Appendix D In: Executive summary—3rd international roundtable: sustaining progress in the life sciences: strategies for managing dual use research of concern. Washington, DC: NIH Office of Biotechnology Activities, 2008;15–23. Available at: oba.od.nih.gov/biosecurity/PDF/Report%20from%203rd%20Rt_Final_18%20May%202009.pdf. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation
  • 15.

    Kahn L. Biodefense research: can secrecy and safety coexist? Biosecur Bioterror 2004; 2: 81–85.

  • 16.

    US Government Accountability Office. CDC select agent program. GAO Report 03-315R. Washington, DC: US Government Accountability Office, 2002. Available at: www.gao.gov/products/GAO-03-315R. Accessed Mar 22, 2012.

    • Search Google Scholar
    • Export Citation
  • 17.

    US Government Accountability Office. Preliminary observations on the oversight of the proliferation of BSL3 and BSL4 laboratories in the United States. GAO report 08-108T. Washington, DC: US Government Accountability Office, 2007. Available at: www.gao.gov/products/GAO-08-108T. Accessed Mar 22, 2012.

    • Search Google Scholar
    • Export Citation
  • 18.

    US Government Accountability Office. High containment laboratories—national strategy for oversight is needed. GAO report 09-574. Washington, DC: US Government Accountability Office, 2009. Available at: www.gao.gov/products/GAO-09-574. Accessed Mar 22, 2012.

    • Search Google Scholar
    • Export Citation
  • 19.

    Gottron FShea DA. Oversight of high-containment biological laboratories: issues for congress. Washington, DC: Congressional Research Service, 2009. Available at: www.fas.org/sgp/crs/terror/R40418.pdf. Accessed Mar 23, 2012.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    Roberts M. Role of regulation in minimizing terrorist threats against the food supply: information, incentives, and penalties. Minn J Law Sci Techol 2006; 8: 199–223.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Tadataka Yamada MD. Poverty, wealth, and access to pandemic influenza vaccines. N Engl J Med 2009; 361: 1129–1131.

  • 22.

    Faden RRKarron RA. Public health & biosecurity: the obligation to prevent the next dual-use controversy. Science 2012; 335: 802–804.

    • Search Google Scholar
    • Export Citation
  • 23.

    Sutton V. Survey finds biodefense researcher anxiety—over inadvertently violating regulations. Biosecur Bioterr 2009; 7: 225–226.

    • Search Google Scholar
    • Export Citation
  • 24.

    National Science Advisory Board for Biosecurity. Enhancing personnel reliability among individuals with access to select agents: report of the National Science Advisory Board for Biosecurity. Washington, DC: National Science Advisory Board for Biosecurity, 2009. Available at: oba.od.nih.gov/biosecurity/meetings/200905T/NSABB%20Final%20Report%20on%20PR%205-29-09.pdf. Accessed Feb 18, 2011.

    • Search Google Scholar
    • Export Citation

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