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Determination of the minimum anesthetic concentration of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha)

Kristen A. Phair DVM1, R. Scott Larsen DVM, MS2, Raymund F. Wack DVM, MS3, Yael Shilo-Benjamini DVM4, and Bruno H. Pypendop DrMedVet, DrVetSci5
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  • 1 Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
  • | 2 Denver Zoo, 2300 Steele St, Denver, CO 80205.
  • | 3 Wildlife Health Center and Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
  • | 4 Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
  • | 5 Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.

Abstract

Objective—To determine the minimum anesthetic concentration (MAC) of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha) and compare MAC obtained via mechanical and electrical stimulation.

Animals—15 healthy thick-billed parrots.

Procedures—Anesthesia was induced in each parrot by administration of sevoflurane in oxygen. An end-tidal sevoflurane concentration of 2.5% was established in the first bird. Fifteen minutes was allowed for equilibration. Then, 2 types of noxious stimulation (mechanical and electrical) were applied; stimuli were separated by 15 minutes. Responses to stimuli were graded as positive or negative. For a positive or negative response to a stimulus, the target end-tidal sevoflurane concentration of the subsequent bird was increased or decreased by 10%, respectively. The MAC was calculated as the mean end-tidal sevoflurane concentration during crossover events, defined as instances in which independent pairs of birds evaluated in succession had opposite responses. A quantal method was used to determine sevoflurane MAC. Physiologic variables and arterial blood gas values were also measured.

Results—Via quantal analysis, mean sevoflurane MAC in thick-billed parrots determined with mechanical stimulation was 2.35% (90% fiducial interval, 1.32% to 2.66%), which differed significantly from the mean sevoflurane MAC determined with electrical stimulation, which was 4.24% (90% fiducial interval, 3.61% to 8.71%).

Conclusions and Clinical Relevance—Sevoflurane MAC in thick-billed parrots determined by mechanical stimulation was similar to values determined in chickens and mammals. Sevoflurane MAC determined by electrical stimulation was significantly higher, which suggested that the 2 types of stimulation did not induce similar results in thick-billed parrots.

Contributor Notes

Dr. Phair's present address is Zoological Society of San Diego, POBox 120551, San Diego, CA 92112.

Supported by the Center for Companion Animal Health and the Veterinary Medicine Teaching Hospital, School of Veterinary Medicine, University of California-Davis, and the Sacramento Zoological Society.

The authors thank Neil Willits and Chalon Majewski-Tiedeken for technical assistance.

Address correspondence to Dr. Phair (kaphair@gmail.com).