Concerns about Leptospira vaccine efficacy study

  • 1. Rinehart CL, Zimmerman AD, Buterbaugh RE, et al. Efficacy of vaccination of cattle with the Leptospira interrogans serovar hardjo type hardjoprajitno component of a pentavalent Leptospira bacterin against experimental challenge with Leptospira borgpetersenii serovar hardjo type hardjo-bovis. Am J Vet Res 2012; 73:735740.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2. Bolin CA, Thiermann AB, Handsaker AL, et al. Effect of vaccination with a pentavalent leptospiral vaccine on Leptospira interrogans serovar hardjo type hardjo-bovis infection of pregnant cattle. Am J Vet Res 1989; 50:161165.

    • Search Google Scholar
    • Export Citation
  • 3. Bolin CA, Zuerner RL, Trueba G. Effect of vaccination with a pentavalent leptospiral vaccine containing Leptospira interrogans serovar hardjo type hardjo-bovis on type hardjo-bovis infection of cattle. Am J Vet Res 1989; 50:20042008.

    • Search Google Scholar
    • Export Citation
  • 4. Bolin CA, Cassells JA, Zuerner RL, et al. Effect of vaccination with a monovalent Leptospira interrogans serovar hardjo type hardjo-bovis vaccine on type hardjo-bovis infection of cattle. Am J Vet Res 1991; 52:16391643.

    • Search Google Scholar
    • Export Citation
  • 5. Bolin CA, Alt DP. Use of a monovalent leptopsiral vaccine to prevent renal colonization and urinary shedding in cattle exposed to Leptospria borpetersenii serovar hardjo. Am J Vet Res 2001; 62:9951000.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. Zuerner RL, Alt DP, Palmer MV, et al. A Leptospira borgpetersenii serovar Hardjo vaccine induces a Th1 response, activates NK cells, and reduces renal colonization. Clin Vaccine Immunol 2011; 18:684691.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7. Naimann BM, Blumerman S, Alt D, et al. Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar hardjo: involvement of WC1+ and CD4 T cells. Infect Immun 2002; 70:61476157.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8. Smith CR, Ketterer PJ, McGowan MR, et al. A review of laboratory techniques and their use in the diagnosis of Leptospira interrogans serovar hardjo infection in cattle. Aust Vet J 1994; 71:290294.

    • Crossref
    • Search Google Scholar
    • Export Citation

Advertisement