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Use of recombinant human granulocyte colony-stimulating factor prior to autologous bone marrow transplantation in dogs with lymphoma

Amy E. Lane BVSc1, Marisa J. Y. Chan BSc, BVMS2, and Kenneth M. Wyatt BSc, BVMS3
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  • 1 Perth Veterinary Oncology, 305 Selby St N, Osborne Park, WA 6014, Australia.
  • | 2 Veterinary Medicine Specialists, 305 Selby St N, Osborne Park, WA 6014, Australia.
  • | 3 Perth Veterinary Oncology, 305 Selby St N, Osborne Park, WA 6014, Australia.

Abstract

Objective—To retrospectively assess the safety and efficacy of recombinant human granulocyte colony-stimulating factor (G-CSF) used as part of autologous bone marrow transplantation in dogs with lymphoma.

Animals—21 dogs with lymphoma at any disease stage.

Procedures—Medical records of dogs with lymphoma that underwent intensified chemotherapy and received an autologous bone marrow transplant following owner administration of recombinant human G-CSF (5 μg/kg, SC, q 12 h) for 7 days between January 2007 and July 2009 were reviewed. Results of physical examinations and CBCs performed before and at intervals during a 24-month period after G-CSF treatment were assessed. The safety of recombinant human G-CSF administration was determined via assessment of both short-term (ie, during the 7-day G-CSF treatment period) and long-term adverse effects.

Results—None of the dogs developed any adverse effect attributable to the administration of recombinant human G-CSF during G-CSF administration or during follow-up periods of 1 month to 2 years (median follow-up period, 4 months). Among the 18 dogs for which CBC results were available for analysis, mean circulating neutrophil count significantly increased after administration of recombinant human G-CSF, compared with value before treatment.

Conclusions and Clinical Relevance—Results indicated that recombinant human G-CSF administered SC at a dosage of 5 μg/kg every 12 hours for 7 days appeared to be safe and effective when used in dogs with lymphoma that were undergoing autologous bone marrow transplant.

Contributor Notes

Address correspondence to Dr. Lane (amy@pvo.com.au).