Evaluation of glomerular filtration rate by use of dynamic computed tomography and Patlak analysis in clinically normal cats

Jinhwa Chang Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.

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Sejoon Ahn Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.

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Sooyoung Choi Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.

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Heechun Lee Department of Medical Imaging, College of Veterinary Medicine, Gyeongsang National University, Jinju, 600-701, South Korea.

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Dongwoo Chang Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju-si, 361-763, South Korea.

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Hojung Choi Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.

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Youngwon Lee Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.

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Abstract

Objective—To obtain quantitative variables of the abdominal aorta and both kidneys on the basis of time-attenuation curves (TACs) and to measure glomerular filtration rate (GFR) for each kidney and the global GFR in clinically normal cats by use of dynamic computed tomography (CT) and Patlak analysis.

Animals—9 healthy cats.

Procedures—All the cats were anesthetized with propofol. Anesthesia was maintained by administration of isoflurane, and CT examination was performed in the anesthetized cats. The TACs and renal volume were measured by use of the baseline precontrast and single-slice dynamic scans. The CT-GFR of each kidney and the global CT-GFRs were calculated via Patlak plot analysis.

Results—CT-GFR results from 7 cats were valid. Peak aortic enhancement was detected between 9.0 and 14.0 seconds after iohexol injection, and the initial peak time of renal parenchymal enhancement was 15 to 24 seconds after iohexol injection. Mean ± SD global GFR was 2.06 ± 0.62 mL/min/kg. Mean ± SD CT-GFR of the right and left kidneys was 0.97 ± 0.32 mL/min/kg and 1.05 ± 0.31 mL/min/kg, respectively.

Conclusions and Clinical Relevance—The CT-GFR method can be rapidly and conveniently performed in clinically normal cats. This combined structural-functional approach provided physiologic and morphological information on the kidneys of cats.

Abstract

Objective—To obtain quantitative variables of the abdominal aorta and both kidneys on the basis of time-attenuation curves (TACs) and to measure glomerular filtration rate (GFR) for each kidney and the global GFR in clinically normal cats by use of dynamic computed tomography (CT) and Patlak analysis.

Animals—9 healthy cats.

Procedures—All the cats were anesthetized with propofol. Anesthesia was maintained by administration of isoflurane, and CT examination was performed in the anesthetized cats. The TACs and renal volume were measured by use of the baseline precontrast and single-slice dynamic scans. The CT-GFR of each kidney and the global CT-GFRs were calculated via Patlak plot analysis.

Results—CT-GFR results from 7 cats were valid. Peak aortic enhancement was detected between 9.0 and 14.0 seconds after iohexol injection, and the initial peak time of renal parenchymal enhancement was 15 to 24 seconds after iohexol injection. Mean ± SD global GFR was 2.06 ± 0.62 mL/min/kg. Mean ± SD CT-GFR of the right and left kidneys was 0.97 ± 0.32 mL/min/kg and 1.05 ± 0.31 mL/min/kg, respectively.

Conclusions and Clinical Relevance—The CT-GFR method can be rapidly and conveniently performed in clinically normal cats. This combined structural-functional approach provided physiologic and morphological information on the kidneys of cats.

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