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-
1.
Terzioglu T, Yalti T, Tezelman S. The effect of prostaglandin E1 on experimental colitis in the rat. Int J Colorectal Dis 1997; 12:63–66.
-
2.
Nakai M, Uchida H, Hanaoka T, et al. Beneficial effects of prostaglandin E1 on ischemic colitis following surgery on the abdominal aorta. Surg Today 1998; 28:1146–1153.
-
3.
Sasaki S, Hirata I, Maemura K, et al. Prostaglandin E2 inhibits lesion formation in dextran sodium sulphate-induced colitis in rats and reduces the levels of mucosal inflammatory cytokines. Scand J Immunol 2000; 51:23–28.
-
4.
Pai R, Soreghan B, Szabo IL, et al. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 2002; 8:289–293.
-
5.
Cosme R, Lublin D, Takafuji V, et al. Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression. Hum Immunol 2000; 61:684–696.
-
6.
Kawamori T, Uchiya N, Sugimura T, et al. Enhancement of colon carcinogenesis by prostaglandin E2 administration. Carcinogenesis 2003; 24:985–990.
-
7.
Riviere PJ, Farmer SC, Burks TF, et al. Prostaglandin E2-induced diarrhea in mice: importance of colonic secretion. J Pharmacol Exp Ther 1991; 256:547–552.
-
8.
Calderaro V, Giovane A, De Simone B, et al. Arachidonic acid metabolites and chloride secretion in rabbit distal colonic mucosa. Am J Physiol 1991; 261:G443–G450.
-
9.
Wiercinska-Drapalo A, Flisiak R, Prokopowicz D. Effects of ulcerative colitis activity on plasma and mucosal prostaglandin E2 concentration. Prostaglandins Other Lipid Mediat 1999; 58:159–165.
-
10.
Steven K, Lange P, Bukhave K, et al. Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. Gastroenterology 1981; 80:1562–1566.
-
11.
Inaba A, Uchiyama T, Oka M. Role of prostaglandin E2 in rat colon carcinoma. Hepatogastroenterology 1999; 46:2347–2351.
-
12.
Hull MA, Gardner SH, Hawcroft G. Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. Cancer Treat Rev 2003; 29:309–320.
-
13.
Sandle GI, Wills NK, Alles W, et al. Electrophysiology of the human colon: evidence of segmental heterogeneity. Gut 1986; 27:999–1005.
-
14.
Sandle GI & McGlone E Segmental variability of membrane conductances in rat and human colonic epithelia. Implications for Na, Kand Cl transport. Pflugers Arch 1987; 410:173–180.
-
15.
Rangachari PK, McWade D. Epithelial and mucosal preparations of canine proximal colon in Ussing chambers: comparison of responses. Life Sci 1986; 38:1641–1652.
-
16.
Rangachari PK, McWade D. Histamine stimulation of canine colonic epithelium: potentiation by hydroxylamines. Eur J Pharmacol 1987; 135:331–335.
-
17.
Keenan CM, Rangachari PK. Eicosanoid interactions in the canine proximal colon. Am J Physiol 1989; 256:G673–G679.
-
18.
Rangachari PK, Prior T, McWade D. Epithelial and mucosal preparations from canine colon: responses to substance P. J Pharmacol Exp Ther 1990; 254:1076–1083.
-
19.
Keenan CM, Rangachari PK. Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. Am J Physiol 1991; 260:G481–G488.
-
20.
Rangachari PK, Berezin M, Prior T. Effects of bradykinin on the canine proximal colon. Regul Pept 1993; 46:511–522.
-
21.
Rangachari PK, Betti PA. Biological activity of metabolites of PGD2 on canine proximal colon. Am J Physiol 1993; 264:G886–G894.
-
22.
Rangachari PK, Prior T. Functional subtyping of histamine receptors on the canine proximal colonic mucosa. J Pharmacol Exp Ther 1994; 271:1016–1026.
-
23.
Cody RP, Smith JK. Repeated measures designs. In: Applied statistics and the SAS programming language. 2nd ed. New York: Elsevier Science Publishing Co Inc, 1987;133–177.
-
24.
Sandle GI. Mechanisms of colonic electrolyte absorption and secretion. Dig Dis 1988; 6:1–14.
-
25.
Rolfe V. Colonic fluid and electrolyte transport in health and disease. Vet Clin North Am Small Anim Pract 1999; 29:577–588.
-
26.
Riegler M, Castagliuolo I, Wlk M, et al. Substance P causes a chloride-dependent short-circuit current response in rabbit colonic mucosa in vitro. Scand J Gastroenterol 1999; 34:1203–1211.
-
27.
Engelmann BE, Bindslev N, Poulsen SS, et al. Effects of cyclo-oxygenase and lipoxygenase inhibition on basal- and serotonin-induced ion transport in rat colon. Comp Biochem Physiol C Toxicol Pharmacol 2002; 132:37–52.
-
28.
Clarke LL, Argenzio RA. NaCl transport across equine proximal colon and the effect of endogenous prostanoids. Am J Physiol 1990; 259:G62–G69.
-
29.
Frizzell RA, Koch MJ, Schultz SG. Ion transport by rabbit colon. I. Active and passive components. J Membr Biol 1976; 27:297–316.
-
30.
Halevy J, Budinger ME, Hayslett JP, et al. Role of aldosterone in the regulation of sodium and chloride transport in the distal colon of sodium-depleted rats. Gastroenterology 1986; 91:1227–1233.
-
31.
Pacha J, Pohlova I, Karen P. Regulation of amiloride-sensitive Na+ transport in immature rat distal colon by aldosterone. Pediatr Res 1995; 38:356–360.
-
32.
Travis SP, Jewell DP. Regional differences in the response to platelet-activating factor in rabbit colon. Clin Sci (Lond) 1992; 82:673–680.
-
33.
Travis SP, Crotty B, Jewell DP. Site of action of platelet-activating factor within the mucosa of rabbit distal colon. Clin Sci (Lond) 1995; 88:51–57.
-
34.
Argenzio RA, Liacos JA. Endogenous prostanoids control ion transport across neonatal porcine ileum in vitro. Am J Vet Res 1990; 51:747–751.
-
35.
Ussing HH, Zerahn K. Active transport of sodium and the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand 1951; 23:110–127.
-
36.
Diener M, Bridges RJ, Knobloch SF, et al. Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens. Naunyn Schmiedebergs Arch Pharmacol 1988; 337:74–78.
-
37.
Halm DR, Halm ST. Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways. Am J Physiol Gastrointest Liver Physiol 2001; 281:G984–G996.
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Evaluation of the secretory response to endogenous and exogenous prostaglandins in mucosa from the proximal and distal portions of the colon of dogs
Abstract
Objective—To compare secretory responses to prostaglandin (PG) E2 in mucosa obtained from the proximal and distal portions of the colon of dogs.
Sample—Colonic mucosa from cadavers of 18 clinically normal adult dogs.
Procedures—Short-circuit current (ISC) and maximum change in ISC (ΔIsc) in response to administration of 1μM PGE2 were measured across mucosa obtained from the proximal and distal portions of the colon. Responses were evaluated in mucosa (n = 6 dogs) incubated in Ussing chambers with or without 1 mM amiloride or without chloride in the Ringer's bathing solution. Responses were also evaluated in mucosa (n = 9 dogs) incubated with or without pretreatment with 1 μM indomethacin, with or without amiloride in the subsequent bathing solution. Histologic changes in mucosa from 3 dogs were assessed over time.
Results—ISC and ΔISC were significantly reduced when chloride was removed from, but not when amiloride was added to, the bathing solution and were significantly reduced after pretreatment with indomethacin. The ΔISC was significantly greater in mucosa from the distal portion of the colon than in the proximal portion of the colon. Histologic changes after incubation for 3 hours were minimal.
Conclusions and Clinical Relevance—ISC and ΔISC resulted from electrogenic chloride secretion. Chloride secretion was reduced when release of PGs was prevented by indomethacin and was induced by administration of PGE2. Chloride secretion in response to PGE2 was greater in mucosa from the distal portion of the colon than in mucosa from the proximal portion of the colon.
Contributor Notes
Dr. Omori's present address is 12634 Carmel Country Rd 117, San Diego, CA 92130.
Dr. Lester's present address is Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Perth, WA 6150, Australia.
Dr. Hill was supported in part by the Waltham Centre for Pet Nutrition.
Published as University of Florida College of Veterinary Medicine Journal Series No. 657.
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