• 1.

    Griffin D. Economic impact associated with respiratory disease in beef cattle. Vet Clin N Am Food Anim Pract 1997; 13: 367377.

  • 2.

    Bateman KG, Martin SW, Shewen PE, et al. An evaluation of antimicrobial therapy for undifferentiated bovine respiratory disease. Can Vet J 1990; 31: 689696.

    • Search Google Scholar
    • Export Citation
  • 3.

    Martin SW, Bateman KG, Shewen PE, et al. A group level analysis of the associations between antibodies to seven putative pathogens and respiratory disease and weight gain in Ontario feedlot calves. Can J Vet Res 1990; 54: 337342.

    • Search Google Scholar
    • Export Citation
  • 4.

    Morck DW, Merrill JK, Thorlakson BE, et al. Prophylactic efficacy of tilmicosin for bovine respiratory tract disease. J Am Vet Med Assoc 1993; 202: 273277.

    • Search Google Scholar
    • Export Citation
  • 5.

    Galyean ML, Gunter SA, Malcolm-Callis KJ. Effects of arrival medication with tilmicosin phosphate on health and performance of newly received beef cattle. J Anim Sci 1995; 73: 12191226.

    • Search Google Scholar
    • Export Citation
  • 6.

    Wittum TE, Perino LJ. Passive immune status at postpartum hour 24 and long-term health and performance of calves. Am J Vet Res 1995; 56: 11491154.

    • Search Google Scholar
    • Export Citation
  • 7.

    Wittum TE, Woollen NE, Perino LJ, et al. Relationships among treatment for respiratory tract disease, pulmonary lesions evident at slaughter, and rate of weight gain in feedlot cattle. J Am Vet Med Assoc 1996; 209: 814818.

    • Search Google Scholar
    • Export Citation
  • 8.

    Gardner BA, Dolezal HG, Bryant LK, et al. Health of finishing steers: effects on performance, carcass traits, and meat tenderness. J Anim Sci 1999; 77: 31683175.

    • Search Google Scholar
    • Export Citation
  • 9.

    Buhman MJ, Perino LJ, Galyean ML, et al. Association between changes in eating and drinking behaviors and respiratory tract disease in newly arrived calves at a feedlot. Am J Vet Res 2000; 61: 11631168.

    • Search Google Scholar
    • Export Citation
  • 10.

    Thompson PN, Stone A, Schultheiss WA. Use of treatment records and lung lesion scoring to estimate the effect of respiratory disease on growth during early and late finishing periods in South African feedlot cattle. J Anim Sci 2006; 84: 488498.

    • Search Google Scholar
    • Export Citation
  • 11.

    Bryant LK, Perino LJ, Griffin D, et al. A method for recording pulmonary lesions of beef calves at slaughter, and the association of lesions with average daily gain. Bovine Pract 1999; 33: 163173.

    • Search Google Scholar
    • Export Citation
  • 12.

    Slocombe RF, Malark J, Ingersoll R, et al. Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves. Am J Vet Res 1985; 46: 22532258.

    • Search Google Scholar
    • Export Citation
  • 13.

    Breider MA, Walker RD, Hopkins FM, et al. Pulmonary lesions induced by Pasteurella haemolytica in neutrophil sufficient and neutrophil deficient calves. Can J Vet Res 1988; 52: 205209.

    • Search Google Scholar
    • Export Citation
  • 14.

    Weiss DJ, Bauer MC, Whiteley LO, et al. Changes in blood and bronchoalveolar lavage fluid components in calves with experimentally induced pneumonic pasteurellosis. Am J Vet Res 1991; 52: 337344.

    • Search Google Scholar
    • Export Citation
  • 15.

    Bednarek D, Zdzisinska B, Kondracki M, et al. Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia. Vet Microbiol 2003; 96: 5367.

    • Search Google Scholar
    • Export Citation
  • 16.

    Friton GM, Cajal C, Ramirez-Romero R. Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle. Vet Rec 2005; 156: 809811.

    • Search Google Scholar
    • Export Citation
  • 17.

    Lockwood PW, Johnson JC, Katz TL. Clinical efficacy of flunixin, carprofen and ketoprofen as adjuncts to the antibacterial treatment of bovine respiratory disease. Vet Rec 2003; 152: 392394.

    • Search Google Scholar
    • Export Citation
  • 18.

    Guzel M, Karakurum MC, Durgut R, et al. Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves. Aust Vet J 2010; 88: 236239.

    • Search Google Scholar
    • Export Citation
  • 19.

    Elitok B, Elitok OM. Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease. J Vet Pharmacol Ther 2004; 27: 317320.

    • Search Google Scholar
    • Export Citation
  • 20.

    Hellwig DH, Kegley EB, Johnson Z, et al. The use of flunixin meglumine as adjunct therapy for bovine respiratory disease in stocker cattle, in Proceedings. 32nd Annu Conf Am Assoc Bovine Pract 1999; 32:228.

    • Search Google Scholar
    • Export Citation
  • 21.

    Hannon SJ, Perrett T, Wildman BK, et al. Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of un-differentiated fever in feedlot calves. Vet Ther 2009; 10:E1E18.

    • Search Google Scholar
    • Export Citation
  • 22.

    Van Donkersgoed J, Berg J, Hendrick S. A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves. Vet Ther 2009; 10: 7885.

    • Search Google Scholar
    • Export Citation
  • 23.

    Christie BM, Pierson RE, Braddy PM, et al. Efficacy of corticosteroids as supportive therapy for bronchial pneumonia in yearling feedlot cattle. Bovine Pract 1977; 12: 115117.

    • Search Google Scholar
    • Export Citation
  • 24.

    Sustronck B, Deprez P, Van Loon G, et al. Efficacy of the combination sodium ceftiofur-flumethasone in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Zentralbl Veterinarmed A 1997; 44: 179187.

    • Search Google Scholar
    • Export Citation
  • 25.

    Moire N, Roy O, Gardey L. Effects of dexamethasone on distribution and function of peripheral mononuclear blood cells in pneumonic calves. Vet Immunol Immunopathol 2002; 87: 459466.

    • Search Google Scholar
    • Export Citation
  • 26.

    Espinasse J, Bost F, Madelenat A, et al. Efficacite d'une nouvelle cephalosporine (ceftiofur) associee ou non a un antiinflammatoire steroidien (succinate de methyl prednisolone) dans un modele experimental de pasteurellose respiratoire du veau a Pasteurella haemolytica bio-serogroupe A1. Rev Med Vet (Toulouse) 1992; 143: 913917.

    • Search Google Scholar
    • Export Citation
  • 27.

    Shewen PE, Wilkie BN. Vaccination of calves with leukotoxic culture supernatant from Pasteurella haemolytica. Can J Vet Res 1988; 52: 3036.

    • Search Google Scholar
    • Export Citation
  • 28.

    Greer CN, Shewen PE. Automated colorimetric assay for the detection of Pasteurella haemolytica leucotoxin. Vet Microbiol 1986; 12: 3342.

    • Search Google Scholar
    • Export Citation
  • 29.

    Steel RGD, Torrie JH, Dickey DA. Principles and procedures of statistics: a biometrical approach. 3rd ed. Boston: WCB/McGraw-Hill, 1997;606609.

    • Search Google Scholar
    • Export Citation
  • 30.

    Malazdrewich C, Thumbikat P, Maheswaran SK. Protective effect of dexamethasone in experimental bovine pneumonic mannheimiosis. Microb Pathog 2004; 36: 227236.

    • Search Google Scholar
    • Export Citation
  • 31.

    Mitchell GB, Clark ME, Caswell JL. Alterations in the bovine bronchoalveolar lavage proteome induced by dexamethasone. Vet Immunol Immunopathol 2007; 118: 283293.

    • Search Google Scholar
    • Export Citation
  • 32.

    Beveridge JD, Mitchell GB, Brewer D, et al. Altered protein expression in neutrophils of calves treated with dexamethasone. Can J Vet Res 2008; 72: 249252.

    • Search Google Scholar
    • Export Citation
  • 33.

    Sowell BF, Branine ME, Bowman JGP, et al. Feeding and watering behavior of healthy and morbid steers in a commercial feedlot. J Anim Sci 1999; 77: 11051112.

    • Search Google Scholar
    • Export Citation
  • 34.

    Schunicht OC, Booker CW, Jim GK, et al. Comparison of a multivalent viral vaccine program versus a univalent viral vaccine program on animal health, feedlot performance, and carcass characteristics of feedlot calves. Can Vet J 2003; 44: 4350.

    • Search Google Scholar
    • Export Citation
  • 35.

    Sielman ES, Sweeney RW, Whitlock RH, et al. Hypokalemia syndrome in dairy cows: 10 cases (1992–1996). J Am Vet Med Assoc 1997; 210: 240243.

    • Search Google Scholar
    • Export Citation
  • 36.

    Coffer NJ, Frank N, Elliott SB, et al. Effects of dexamethasone and isoflupredone acetate on plasma potassium concentrations and other biochemical measurements in dairy cows in early lactation. Am J Vet Res 2006; 67: 12441251.

    • Search Google Scholar
    • Export Citation

Advertisement

Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia

Joanne Hewson DVM, PhD1, Laurent Viel DVM, PhD2, Jeff L. Caswell DVM, PhD3, Patricia E. Shewen DVM, PhD4, and Jock G. Buchanan-Smith PhD5
View More View Less
  • 1 Department of Pathobiology, Ontario Veterinary College, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • | 2 Department of Clinical Studies, Ontario Veterinary College, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • | 3 Department of Pathobiology, Ontario Veterinary College, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • | 4 Department of Pathobiology, Ontario Veterinary College, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • | 5 Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.

Abstract

Objective—To characterize the impact of Mannheimia haemolytica infection on feed intake and weight gain in feedlot heifers and to evaluate the clinical efficacy of isoflupredone acetate administered in combination with oxytetracycline.

Animals—96 weanling heifers in a research feedlot facility.

Procedures—Bronchopneumonia was induced by intrabronchial infusion of M haemolytica. Control heifers underwent a sham procedure. Infected heifers were treated with oxytetracycline alone or in combination with isoflupredone acetate (OXY-ISO) or with nothing. Clinical variables were recorded daily for 7 days following disease induction, and feedlot performance indices were measured over a 12-week period.

Results—Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers that received no treatment. Oxytetracycline treatment alone did not prevent reductions in feed intake and ADG during the first week after infection was induced, whereas OXY-ISO treatment did prevent these reductions. Treatment with OXY-ISO also resulted in faster clinical improvement. No significant differences were evident between the oxytetracycline and OXY-ISO groups with respect to dry-matter intake or ADG throughout the study period.

Conclusions and Clinical Relevance—Isoflupredone acetate appeared to be a useful clinical adjunct to treatment with oxytetracycline in cattle with acute M haemolytica bronchopneumonia.

Abstract

Objective—To characterize the impact of Mannheimia haemolytica infection on feed intake and weight gain in feedlot heifers and to evaluate the clinical efficacy of isoflupredone acetate administered in combination with oxytetracycline.

Animals—96 weanling heifers in a research feedlot facility.

Procedures—Bronchopneumonia was induced by intrabronchial infusion of M haemolytica. Control heifers underwent a sham procedure. Infected heifers were treated with oxytetracycline alone or in combination with isoflupredone acetate (OXY-ISO) or with nothing. Clinical variables were recorded daily for 7 days following disease induction, and feedlot performance indices were measured over a 12-week period.

Results—Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers that received no treatment. Oxytetracycline treatment alone did not prevent reductions in feed intake and ADG during the first week after infection was induced, whereas OXY-ISO treatment did prevent these reductions. Treatment with OXY-ISO also resulted in faster clinical improvement. No significant differences were evident between the oxytetracycline and OXY-ISO groups with respect to dry-matter intake or ADG throughout the study period.

Conclusions and Clinical Relevance—Isoflupredone acetate appeared to be a useful clinical adjunct to treatment with oxytetracycline in cattle with acute M haemolytica bronchopneumonia.

Contributor Notes

Dr. Hewson's present address is Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

This manuscript represents a thesis submitted by the first author as partial fulfillment for the requirements of a Doctor of Philosophy degree from the Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Supported by grants from the Ontario Cattlemen's Association and the Ontario Ministry of Agriculture, Food and Rural Affairs.

Presented in part as an abstract at the 20th Annual Meeting of the American College of Veterinary Internal Medicine, Dallas, May 2002.

The authors thank Betty Anne McBey for technical assistance and William Sears and Gabrielle Monteith for statistical advice.

Address correspondence to Dr. Hewson (jhewson@uoguelph.ca).