Cover American Journal of Veterinary Research
American Journal of Veterinary Research
ISSN:
0002-9645
Publication Date:
01 Dec 2011
  • 1.

    Hill R. NK1 (substance P) receptor antagonists—why are they not analgesic in humans?. Trends Pharmacol Sci 2000; 21: 244–246.

  • 2.

    Rost K, Fleischer F, Nieber K. Neurokinin 1 receptor antagonists—between hope and disappointment. Med Monatsschr Pharm 2006; 29: 200–205.

    • Search Google Scholar
    • Export Citation
  • 3.

    Laird JM, Olivar T, Roza C, et al. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. Neuroscience 2000; 98: 345–352.

    • Search Google Scholar
    • Export Citation
  • 4.

    Ruggieri MR, Filer-Maerten S, Hieble JP, et al. Role of neurokinin receptors in the behavioral effect of intravesical antigen infusion in guinea pig bladder. J Urol 2000; 164: 197–202.

    • Search Google Scholar
    • Export Citation
  • 5.

    Okano S, Ikeura Y, Inatomi N. Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits. J Pharmacol Exp Ther 2002; 300: 925–931.

    • Search Google Scholar
    • Export Citation
  • 6.

    Laird J. Gut feelings about tachykinin NK1 receptor antagonists (lett). Trends Pharmacol Sci 2001; 22:169.

  • 7.

    Greenwood-Van Meerveld B, Gibson MS, Johnson AC, et al. NK1 receptor-mediated mechanisms regulate colonic hypersensitivity in the guinea pig. Pharmacol Biochem Behav 2003; 74: 1005–1013.

    • Search Google Scholar
    • Export Citation
  • 8.

    Sakurada T, Katsumata K, Yogo H, et al. The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test. Pain 1995; 60: 175–180.

    • Search Google Scholar
    • Export Citation
  • 9.

    Laird JM, Roza C, De Felipe C, et al. Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice. Pain 2001; 90: 97–103.

    • Search Google Scholar
    • Export Citation
  • 10.

    Finnerup NB, Otto M, McQuay HJ, et al. Algorithm for neuropathic pain treatment: an evidence based proposal. Pain 2005; 118: 289–305.

  • 11.

    Gilron I. Is gabapentin a “broad-spectrum” analgesic?. Anesthesiology 2002; 97: 537–539.

  • 12.

    Rose MA, Kam PC. Gabapentin: pharmacology and its use in pain management. Anaesthesia 2002; 57: 451–462.

  • 13.

    Mitra S. Opioid-induced hyperalgesia: pathophysiology and clinical implications. J Opioid Manag 2008; 4: 123–130.

  • 14.

    Cohen SP, Christo PJ, Moroz L. Pain management in trauma patients. Am J Phys Med Rehabil 2004; 83: 142–161.

  • 15.

    Brain SD. Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology 1997; 37: 133–152.

  • 16.

    Inoue M, Kobayashi M, Kozaki S, et al. Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc Natl Acad Sci U S A 1998; 95: 10949–10953.

    • Search Google Scholar
    • Export Citation
  • 17.

    Duggan AW, Hendry IA, Morton CR, et al. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res 1988; 451: 261–273.

    • Search Google Scholar
    • Export Citation
  • 18.

    Lawson SN, Crepps BA, Perl ER. Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. J Physiol 1997; 505: 177–191.

    • Search Google Scholar
    • Export Citation
  • 19.

    Zachariou V, Goldstein BD, Yeomans DC. Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P. Brain Res 1997; 752: 143–150.

    • Search Google Scholar
    • Export Citation
  • 20.

    Morris R, Cheunsuang O, Stewart A, et al. Spinal dorsal horn neurone targets for nociceptive primary afferents: do single neurone morphological characteristics suggest how nociceptive information is processed at the spinal level. Brain Res Brain Res Rev 2004; 46: 173–190.

    • Search Google Scholar
    • Export Citation
  • 21.

    Leah J, Menetrey D, De Pommery J. Neuropeptides in long ascending spinal tract cells in the rat: evidence for parallel processing of ascending information. Neuroscience 1988; 24: 195–207.

    • Search Google Scholar
    • Export Citation
  • 22.

    Battaglia G, Rustioni A. Substance P innervation of the rat and cat thalamus. II. Cells of origin in the spinal cord. J Comp Neurol 1992; 315: 473–486.

    • Search Google Scholar
    • Export Citation
  • 23.

    Gamboa-Esteves FO, Kaye JC, McWilliam PN, et al. Immunohistochemical profiles of spinal lamina I neurones retrogradely labelled from the nucleus tractus solitarii in rat suggest excitatory projections. Neuroscience 2001; 104: 523–538.

    • Search Google Scholar
    • Export Citation
  • 24.

    Andoh T, Nagasawa T, Kuraishi Y. Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia of the mouse. Brain Res Mol Brain Res 1996; 35: 329–332.

    • Search Google Scholar
    • Export Citation
  • 25.

    Yip J, Chahl LA. Localization of tachykinin receptors and Fos-like immunoreactivity induced by substance P in guinea-pig brain. Clin Exp Pharmacol Physiol 2000; 27: 943–946.

    • Search Google Scholar
    • Export Citation
  • 26.

    Mantyh PW, Gates T, Mantyh CR, et al. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci 1989; 9: 258–279.

    • Search Google Scholar
    • Export Citation
  • 27.

    Boscan P, Monnet E, Mama K, et al. A dog model to study ovary, ovarian ligament and visceral pain. Vet Anaesth Analg 2011; 38: 260–266.

  • 28.

    Eger EI II, Eisenkraft JB, Weiskopf RB. MAC. In: The pharmacology of inhaled anesthetics. Chicago: Baxter Healthcare Corp, 2003; 21–32.

  • 29.

    Kelly WB, Howie MB, Romanelli VA, et al. A comparison of pentamorphone and fentanyl in balanced anaesthesia during general surgery. Can J Anaesth 1994; 41: 703–709.

    • Search Google Scholar
    • Export Citation
  • 30.

    Ko JC, Weil AB, Inoue T. Effects of carprofen and morphine on the minimum alveolar concentration of isoflurane in dogs. J Am Anim Hosp Assoc 2009; 45: 19–23.

    • Search Google Scholar
    • Export Citation
  • 31.

    Machado CE, Dyson DH, Grant MM. Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs. Vet Anaesth Analg 2006; 33: 70–77.

    • Search Google Scholar
    • Export Citation
  • 32.

    McEwan AI, Smith C, Dyar O, et al. Isoflurane minimum alveolar concentration reduction by fentanyl. Anesthesiology 1993; 78: 864–869.

  • 33.

    Murphy MR, Hug CC Jr. The enflurane sparing effect of morphine, butorphanol, and nalbuphine. Anesthesiology 1982; 57: 489–492.

  • 34.

    Valverde A, Morey TE, Hernandez J, et al. Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits. Am J Vet Res 2003; 64: 957–962.

    • Search Google Scholar
    • Export Citation

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Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs

Pedro Boscan DVM, PhD1, Eric Monnet DVM, PhD2, Khursheed Mama DVM3, David C. Twedt DVM4, Jonathan Congdon DVM, MSc5, and Eugene P. Steffey DVM, PhD6
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  • 1 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 2 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 3 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 4 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 5 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 6 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
DOI:
https://doi.org/10.2460/ajvr.72.12.1576
Volume/Issue:
Volume 72: Issue 12
Online Publication Date:
01 Dec 2011
Restricted access
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Abstract

Objective—To determine the anesthetic-sparing effect of maropitant, a neurokinin 1 receptor antagonist, during noxious visceral stimulation of the ovary and ovarian ligament in dogs.

Animals—Eight 1-year-old female dogs.

Procedures—Dogs were anesthetized with sevoflurane. Following instrumentation and stabilization, the right ovary and ovarian ligament were accessed by use of laparoscopy. The ovary was stimulated with a traction force of 6.61 N. The minimum alveolar concentration (MAC) was determined before and after 2 doses of maropitant.

Results—The sevoflurane MAC value was 2.12 ± 0.4% during stimulation without treatment (control). Administration of maropitant (1 mg/kg, IV, followed by 30 μg/kg/h, IV) decreased the sevoflurane MAC to 1.61 ± 0.4% (24% decrease). A higher maropitant dose (5 mg/kg, IV, followed by 150 μg/kg/h, IV) decreased the MAC to 1.48 ± 0.4% (30% decrease).

Conclusions and Clinical Relevance—Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs. Results suggest the potential role for neurokinin 1 receptor antagonists to manage ovarian and visceral pain.

Abstract

Objective—To determine the anesthetic-sparing effect of maropitant, a neurokinin 1 receptor antagonist, during noxious visceral stimulation of the ovary and ovarian ligament in dogs.

Animals—Eight 1-year-old female dogs.

Procedures—Dogs were anesthetized with sevoflurane. Following instrumentation and stabilization, the right ovary and ovarian ligament were accessed by use of laparoscopy. The ovary was stimulated with a traction force of 6.61 N. The minimum alveolar concentration (MAC) was determined before and after 2 doses of maropitant.

Results—The sevoflurane MAC value was 2.12 ± 0.4% during stimulation without treatment (control). Administration of maropitant (1 mg/kg, IV, followed by 30 μg/kg/h, IV) decreased the sevoflurane MAC to 1.61 ± 0.4% (24% decrease). A higher maropitant dose (5 mg/kg, IV, followed by 150 μg/kg/h, IV) decreased the MAC to 1.48 ± 0.4% (30% decrease).

Conclusions and Clinical Relevance—Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs. Results suggest the potential role for neurokinin 1 receptor antagonists to manage ovarian and visceral pain.

Contributor Notes

Supported by Morris Animal Foundation grant D08CA-035.

Address correspondence to Dr. Boscan (pboscan@colostate.edu).