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Evaluation of the effects of thiopental, propofol, and etomidate on glomerular filtration rate measured by the use of dynamic computed tomography in dogs

Jinhwa Chang DVM, PhD1, Sujin Kim MS2, Joohyun Jung DVM, PhD3, Heechun Lee DVM, PhD4, Dongwoo Chang DVM, PhD5, Youngwon Lee DVM, PhD6, Inhyung Lee DVM, PhD7, Junghee Yoon DVM, PhD8, and Mincheol Choi DVM, PhD9
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  • 1 Department of Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151–742, South Korea
  • | 2 Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110–460, South Korea
  • | 3 Department of Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151–742, South Korea
  • | 4 Department of Medical Imaging, Gyeongsang National University, Jinju, 600–701, South Korea
  • | 5 Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongjusi, 361–763, South Korea
  • | 6 Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305–764, South Korea
  • | 7 Department of Surgery/Anesthesiology, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, South Korea.
  • | 8 Department of Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151–742, South Korea
  • | 9 Department of Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151–742, South Korea

Abstract

Objective—To evaluate the effects of thiopental, propofol, and etomidate on glomerular filtration rate (GFR) measured by the use of dynamic computed tomography in dogs.

Animals—17 healthy Beagles.

Procedures—Dogs were randomly assigned to receive 2 mg of etomidate/kg (n = 5), 6 mg of propofol/kg (7), or 15 mg of thiopental/kg (5) during induction of anesthesia; anesthesia was subsequently maintained by isoflurane evaporated in 100% oxygen. A 1 mL/kg dosage of a 300 mg/mL solution of iohexol was administered at a rate of 3 mL/s during GFR measurement. Regions of interest of the right kidney were manually drawn to exclude vessels and fatty tissues and highlight the abdominal portion of the aorta. Iohexol clearance per unit volume of the kidney was calculated by use of Patlak plot analysis.

Results—Mean ± SD weight-adjusted GFR of the right kidney after induction of anesthesia with thiopental, propofol, and etomidate was 2.04 ± 0.36 mL/min/kg, 2.06 ± 0.29 mL/min/kg, and 2.14 ± 0.43 mL/min/kg, respectively. However, no significant differences in weight-adjusted GFR were detected among the treatment groups.

Conclusions and Clinical Relevance—Results obtained for the measurement of GFR in anesthetized dogs after anesthetic induction with etomidate, propofol, or thiopental and maintenance with isoflurane did not differ significantly. Therefore, etomidate, propofol, or thiopental can be used in anesthesia-induction protocols that involve the use of isoflurane for maintenance of anesthesia without adversely affecting GFR measurements obtained by the use of dynamic computed tomography in dogs.

Contributor Notes

Address correspondence to Dr. Choi (mcchoi@snu.ac.kr).