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Pharmacokinetics and bioavailability of cefquinome in healthy ducks

Liguo Yuan DVM1, Jian Sun BVSc2, Rui Wang BVSc3, Lihua Sun PhD4, Lixiang Zhu BVSC5, Xianyang Luo BVSc6, Binghu Fang DVM7, and Yahong Liu DVM8
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  • 1 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 2 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 3 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 4 School of Biosciences & Bioengineering, South China University of Technology, Guangzhou 510641, Guangdong, People's Republic of China.
  • | 5 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 6 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 7 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China
  • | 8 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China

Abstract

Objective—To determine pharmacokinetics and bioavailability of cefquinome administered IV, IM, or PO to healthy ducks.

Animals—Thirty-six 2-month-old Muscovy ducks.

Procedures—Ducks were randomly assigned to 3 groups of 12 birds each for a single IV, IM, or PO administration at a dose of 5 mg/kg. Blood samples were collected before and at various intervals after each administration. Cefquinome concentration was determined by use of high-performance liquid chromatography at 268 nm with a UV detector, and pharmacokinetics were analyzed.

Results—The disposition of cefquinome following IV or IM administration was best described by a 2-compartment model. After IV administration, mean ± SD elimination halflife was 1.57 ± 0.06 hours, clearance value was 0.22 ± 0.02 L/kg·h, and apparent volume of distribution at steady state was 0.41 ± 0.04 L/kg. After IM administration, elimination half-life was 1.79 ± 0.13 hours, peak concentration time was 0.38 ± 0.06 hours, peak drug concentration was 9.38 ± 1.61 μg/mL, and absolute mean ± SD bioavailability was 93.28 ± 13.89%. No cefquinome was detected in plasma after PO administration.

Conclusions and Clinical Relevance—Results indicated that cefquinome was absorbed quickly and had excellent bioavailability after IM administration, but absorption after PO administration was poor.

Contributor Notes

Supported by National Key Technologies R&D Program for 11th Five-year Plan 2006BAD31B01 and National Natural Science Foundation of China grants 30471308 and 30771629.

Jian Sun and Liguo Yuan contributed equally to this study.

Address correspondence to Dr. Liu (gale@scau.edu.cn).