Plasma amino acid and whole blood taurine concentrations in cats eating commercially prepared diets

Cailin R. Heinze Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.

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Jennifer A. Larsen Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.

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Philip H. Kass Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.

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Andrea J. Fascetti Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.

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Abstract

Objective—To establish comprehensive reference ranges for plasma amino acid and whole blood taurine concentrations in healthy adult cats eating commercial diets and to evaluate the relationships of age, sex, body weight, body condition score (BCS), dietary protein concentration, and dietary ingredients with plasma amino acid and whole blood taurine concentrations.

Animals—120 healthy adult cats.

Procedures—Blood samples and a complete health and diet history were obtained for each cat, and reference intervals for plasma amino acid and whole blood taurine concentrations were determined. Results were analyzed for associations of age, breed, sex, body weight, BCS, use of heparin, sample hemolysis and lipemia, dietary protein concentrations, and dietary ingredients with amino acid concentrations.

Results—95% reference intervals were determined for plasma amino acid and whole blood taurine concentrations. A significant difference in amino acid concentrations on the basis of sex was apparent for multiple amino acids. There was no clear relationship between age, BCS, body weight, and dietary protein concentration and amino acid concentrations. Differences in amino acid concentrations were detected for various dietary ingredients, but the relationships were difficult to interpret.

Conclusions and Clinical Relevance—This study provided data on plasma amino acid and whole blood taurine concentrations for a large population of adult cats eating commercial diets. Plasma amino acid and whole blood taurine concentrations were not affected by age, BCS, or body weight but were affected by sex and neuter status. Dietary protein concentration and dietary ingredients were not directly associated with plasma amino acid or whole blood taurine concentrations.

Abstract

Objective—To establish comprehensive reference ranges for plasma amino acid and whole blood taurine concentrations in healthy adult cats eating commercial diets and to evaluate the relationships of age, sex, body weight, body condition score (BCS), dietary protein concentration, and dietary ingredients with plasma amino acid and whole blood taurine concentrations.

Animals—120 healthy adult cats.

Procedures—Blood samples and a complete health and diet history were obtained for each cat, and reference intervals for plasma amino acid and whole blood taurine concentrations were determined. Results were analyzed for associations of age, breed, sex, body weight, BCS, use of heparin, sample hemolysis and lipemia, dietary protein concentrations, and dietary ingredients with amino acid concentrations.

Results—95% reference intervals were determined for plasma amino acid and whole blood taurine concentrations. A significant difference in amino acid concentrations on the basis of sex was apparent for multiple amino acids. There was no clear relationship between age, BCS, body weight, and dietary protein concentration and amino acid concentrations. Differences in amino acid concentrations were detected for various dietary ingredients, but the relationships were difficult to interpret.

Conclusions and Clinical Relevance—This study provided data on plasma amino acid and whole blood taurine concentrations for a large population of adult cats eating commercial diets. Plasma amino acid and whole blood taurine concentrations were not affected by age, BCS, or body weight but were affected by sex and neuter status. Dietary protein concentration and dietary ingredients were not directly associated with plasma amino acid or whole blood taurine concentrations.

Contributor Notes

Dr. Heinze's present address is Department of Animal Science, College of Agricultural and Environmental Sciences, University of California-Davis, Davis, CA 95616.

Supported by grants from the Center for Companion Animal Health, School of Veterinary Medicine, University of California-Davis, and the Morris Animal Foundation and by the Nestlé Purina PetCare Company.

Dr. Heinze was supported by an educational grant from the Nestlé Purina PetCare Company.

The authors thank Dr. Zengshou Yu, Deborah Bee, and Tiffany Chan for technical assistance.

Address correspondence to Dr. Fascetti (ajfascetti@ucdavis.edu).
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