Plasma fatty acid concentrations in Boxers and Doberman Pinschers

Caren E. Smith Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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 MS, DVM
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Lisa M. Freeman Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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Kathryn M. Meurs Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

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John E. Rush Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.

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Allison Lamb Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

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Abstract

Objective—To compare plasma fatty acid concentrations and the relationships of fatty acids to arrhythmias in Boxers versus Doberman Pinschers.

Animals—38 Boxers and 13 Doberman Pinschers.

Procedures—Boxers and Doberman Pinschers evaluated via Holter recording and for which a blood sample was available were included. Echocardiograms were performed in 49 of 51 dogs. The number of ventricular premature complexes (VPCs)/24 h was counted and fatty acids analyzed. Plasma fatty acid concentrations and VPCs/24 h, as well as correlations between the 2 variables, were compared between the 2 breeds.

Results—Compared with the Doberman Pinschers, Boxers had significantly higher plasma concentrations of γ-linolenic acid but lower concentrations of arachidonic acid. Total n-6 fatty acids and total polyunsaturated fatty acid concentrations were higher in Doberman Pinschers. There were significant, but weak, positive correlations between VPCs and oleic acid, total n-3 fatty acids, and total n-9 fatty acids in Boxers but not in Doberman Pinschers.

Conclusions and Clinical Relevance—Data suggested that plasma fatty acid concentrations may differ between Boxers and Doberman Pinschers and that the relationship between fatty acid concentrations and VPCs may be different between these 2 breeds.

Abstract

Objective—To compare plasma fatty acid concentrations and the relationships of fatty acids to arrhythmias in Boxers versus Doberman Pinschers.

Animals—38 Boxers and 13 Doberman Pinschers.

Procedures—Boxers and Doberman Pinschers evaluated via Holter recording and for which a blood sample was available were included. Echocardiograms were performed in 49 of 51 dogs. The number of ventricular premature complexes (VPCs)/24 h was counted and fatty acids analyzed. Plasma fatty acid concentrations and VPCs/24 h, as well as correlations between the 2 variables, were compared between the 2 breeds.

Results—Compared with the Doberman Pinschers, Boxers had significantly higher plasma concentrations of γ-linolenic acid but lower concentrations of arachidonic acid. Total n-6 fatty acids and total polyunsaturated fatty acid concentrations were higher in Doberman Pinschers. There were significant, but weak, positive correlations between VPCs and oleic acid, total n-3 fatty acids, and total n-9 fatty acids in Boxers but not in Doberman Pinschers.

Conclusions and Clinical Relevance—Data suggested that plasma fatty acid concentrations may differ between Boxers and Doberman Pinschers and that the relationship between fatty acid concentrations and VPCs may be different between these 2 breeds.

Contributor Notes

Dr. Meurs' present address is Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164. Supported by the Barkley Fund.

Presented in abstract form at the American College of Veterinary Internal Medicine Forum, Baltimore, June 2005.

Address correspondence to Dr. Freeman.
  • 1.

    Petric AD, Stabej P, Zemva A. Dilated cardiomyopathy in Doberman Pinschers: survival, causes of death and a pedigree review in a related line. J Vet Cardiol 2002;4:1724.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Calvert CA, Pickus CW, Jacobs GJ, et al. Signalment, survival, and prognostic factors in Doberman Pinschers with end-stage cardiomyopathy. J Vet Intern Med 1997;11:323326.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Basso C, Fox PR, Meurs KM, et al. Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new model of human disease. Circulation 2004;109:11801185.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Meurs KM, Spiers AW, Miller MW, et al. Familial ventricular arrhythmias in Boxers. J Vet Intern Med 1999;13:437439.

  • 5.

    Davila-Roman VG, Vedala G, Herrero P, et al. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2002;40:271277.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Freeman LM, Rush JE, Kehayias JJ, et al. Nutritional alterations and the effect of fish oil supplementation in dogs with heart failure. J Vet Intern Med 1998;12:440448.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Smith CE, Freeman LM, Meydani M, et al. Myocardial concentrations of fatty acids in dogs with dilated cardiomyopathy. Am J Vet Res 2005;66:14831486.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation 1999;99:24522457.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Marchioli R, Barzi F, Bomba E, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002;105:18971903.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Pepe S, McLennan PL. Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. J Nutr 1996;126:3442.

  • 11.

    Smith CE, Freeman LM, Rush JE, et al. Omega-3 fatty acids in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 2007;21:265273.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911917.

  • 13.

    GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447455.

    • Search Google Scholar
    • Export Citation
  • 14.

    Albert CM, Campos H, Stampfer MJ, et al. Blood levels of longchain n-3 fatty acids and the risk of sudden death. New Engl J Med 2002;346:11131118.

  • 15.

    McLennan PL. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 1993;57:207212.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Calvert CA, Hall G, Jacobs G, et al. Clinical and pathological findings in Doberman Pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure: 54 cases (1984–1991). J Am Vet Med Assoc 1997;210:505511.

    • Search Google Scholar
    • Export Citation
  • 17.

    Kraus MS, Moise NS, Rishniw M, et al. Morphology of ventricular arrhythmias in the boxer as measured by 12-lead electrocardiography with pace-mapping comparison. J Vet Intern Med 2002;16:153158.

    • Crossref
    • Search Google Scholar
    • Export Citation

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