Evaluation of perinuclear anti-neutrophilic cytoplasmic autoantibodies as an early marker of protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers
Search for other papers by Karin Allenspach in
Current site
Google Scholar
PubMed
Search for other papers by Bethany Lomas in
Current site
Google Scholar
PubMed
Search for other papers by Barbara Wieland in
Current site
Google Scholar
PubMed
Search for other papers by Tonya Harris in
Current site
Google Scholar
PubMed
Search for other papers by Barrak Pressler in
Current site
Google Scholar
PubMed
Search for other papers by Carolina Mancho in
Current site
Google Scholar
PubMed
Search for other papers by George E. Lees in
Current site
Google Scholar
PubMed
Search for other papers by Shelly L. Vaden in
Current site
Google Scholar
PubMed
Abstract
Objective—To evaluate perinuclear anti-neutrophilic cytoplasmic autoantibody (pANCA) status in Soft Coated Wheaten Terriers (SCWTs) and SCWT-Beagle crossbred dogs and to correlate pANCA status of dogs with clinicopathologic variables of protein-losing enteropathy (PLE), protein-losing nephropathy (PLN), or both.
Animals—13 SCWTs and 8 SCWT-Beagle crossbred dogs in a research colony and a control group comprising 7 dogs with X-linked hereditary nephropathy and 12 healthy SCWTs > 9 years old.
Procedures—Samples were obtained from dogs in the research colony every 6 months. At each sample-collection time point, serum concentrations of albumin, globulin, creatinine, and urea nitrogen; fecal concentration of α-proteinase inhibitor; and urinary protein-to-creatinine ratios were determined and correlated with pANCA status.
Results—20 of 21 dogs in the research colony had positive results for pANCAs at a minimum of 2 time points, and 18 of 21 dogs had definitive evidence of disease. None of the control dogs had positive results for pANCAs. A positive result for pANCAs was significantly associated with hypoalbuminemia, and pANCAs preceded the onset of hypoalbuminemia on an average of 2.4 years. Sensitivity and specificity for use of pANCAs to predict development of PLE or PLN were 0.95 (95% confidence interval, 0.72 to 1.00) and 0.8 (95% confidence interval, 0.51 to 0.95), respectively.
Conclusions and Clinical Relevance—Most dogs in this study affected with PLE, PLN, or both had positive results for pANCAs before clinicopathologic evidence of disease was detected. Thus, pANCAs may be useful as an early noninvasive test of disease in SCWTs.
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 58 | 0 | 0 |
| Full Text Views | 6751 | 6233 | 72 |
| PDF Downloads | 269 | 104 | 2 |
