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-
1.
Larson BT, Lawler DF, Spitznagel EL Jr, et al. Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs. J Nutr 2003;133:2887–2892.
-
2.
Manek NJ, Lane NE. Osteoarthritis: current concepts in diagnosis and management. Am Fam Physician 2000;61:1795–1804.
-
3.
Karlson EW, Mandl LA, Aweh GN, et al. Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors. Am J Med 2003;114:93–98.
-
4.
Kealy RD, Lawler DF, Ballam JM, et al. Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. J Am Vet Med Assoc 2000;217:1678–1680.
-
5.
Burton-Wurster N, Farese JP, Todhunter RJ, et al. Site-specific variation in femoral head cartilage composition in dogs at high and low risk for development of osteoarthritis: insights into cartilage degeneration. Osteoarthritis Cartilage 1999;7:486–497.
-
6.
Kealy RD, Lawler DF, Ballam JM, et al. Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. J Am Vet Med Assoc 1997;210:222–225.
-
7.
Chapman K, Mustafa Z, Irven C, et al. Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage. Am J Hum Genet 1999;65:167–174.
-
8.
Loughlin J. Osteoarthritis linkage scan: more loci for the geneticists to investigate. Ann Rheum Dis 2006;65:1265–1266.
-
9.
Southam L, Heath O, Chapman K, et al. Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Ann Rheum Dis 2006;65:556–557.
-
10.
Kawahara C, Forster T, Chapman K, et al. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. Ann Rheum Dis 2005;64:474–476.
-
11.
MacGregor AJ, Antoniades L, Matson M, et al. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000;43:2410–2416.
-
12.
Zhai G, Hart DJ, Kato BS, et al. Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study. Osteoarthritis Cartilage 2007;15:222–225.
-
13.
Hays L, Zhang Z, Mateescu RG, et al. Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. Am J Vet Res 2007;68:35–41.
-
14.
Chase K, Lawler DF, Carrier DR, et al. Genetic regulation of osteoarthritis: a QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris). Am J Med Genet A 2005;135:334–335.
-
15.
Chase K, Lawler DF, Adler FR, et al. Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris). Am J Med Genet A 2004;124A:239–247.
-
16.
Todhunter RJ, Mateescu R, Lust G, et al. Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree. Mamm Genome 2005;16:720–730.
-
17.
Olsewski JM, Lust G, Rendano VT, et al. Degenerative joint disease: multiple joint involvement in young and mature dogs. Am J Vet Res 1983;44:1300–1308.
-
18.
Popovitch CA, Smith GK, Gregor TP, et al. Comparison of susceptibility for hip dysplasia between Rottweilers and German Shepherd Dogs. J Am Vet Med Assoc 1995;206:648–650.
-
19.
Todhunter RJ, Acland GM, Olivier M, et al. An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered 1999;90:83–92.
-
20.
Henry GA. Radiographic development of canine hip dysplasia. Vet Clin North Am Small Anim Pract 1992;22:559–578.
-
21.
Cardinet GH III, Guffy MM, Wallace LJ, et al. Canine hip dysplasia in German Shepherd Dog-Greyhound crossbreeds. J Am Vet Med Assoc 1983;182:393–395.
-
22.
Todhunter RJ, Casella G, Bliss SP, et al. Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis. Am J Vet Res 2003;64:418–424.
-
23.
Clark LA, Tsai KL, Steiner JM, et al. Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog. Genomics 2004;84:550–554.
-
24.
Breen M, Hitte C, Lorentzen TD, et al. An integrated 4249 marker FISH/RH map of the canine genome. BMC Genomics 2004;5:65–76.
-
25.
Botstein D, White RL, Skolnick M, et al. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 1980;32:314–331.
-
26.
Seaton G, Haley CS, Knott SA, et al. QTL express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 2002;18:339–340.
-
27.
Bliss S, Todhunter RJ, Quaas R, et al. Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds. Am J Vet Res 2002;63:1029–1035.
-
28.
Lust G, Todhunter RJ, Erb HN, et al. Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. Am J Vet Res 2001;62:1711–1715.
-
29.
Todhunter RJ, Bliss SP, Casella G, et al. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 2003;94:39–48.
-
30.
Chapman K, Mustafa Z, Dowling B, et al. Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs. Arthritis Rheum 2002;46:1780–1783.
-
31.
Loughlin J, Mustafa Z, Smith A, et al. Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology (Oxford) 2000;39:377–381.
-
32.
Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 2004;101:9757–9762.
-
33.
Mototani H, Mabuchi A, Saito S, et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet 2005;14:1009–1017.
-
34.
Loughlin J. Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr Opin Rheumatol 2005;17:629–633.
-
35.
Burton-Wurster N, Mateescu RG, Todhunter RJ, et al. Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChip. J Hered 2005;96:821–828.
-
36.
Mateescu RG, Todhunter RJ, Lust G, et al. Increased MIG-6 mRNA transcripts in osteoarthritic cartilage. Biochem Biophys Res Commun 2005;332:482–486.
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Identification of quantitative trait loci for osteoarthritis of hip joints in dogs
Abstract
Objective—To identify quantitative trait loci (QTL) associated with osteoarthritis (OA) of hip joints of dogs by use of a whole-genome microsatellite scan.
Animals—116 founder, backcross, F1, and F2 dogs from a crossbred pedigree.
Procedures—Necropsy scores and an optimized set of 342 microsatellite markers were used for interval mapping by means of a combined backcross and F2 design module from an online statistical program. Breed and sex were included in the model as fixed effects. Age of dog at necropsy and body weight at 8 months of age were also included in the model as covariates. The chromosomal location at which the highest F score was obtained was considered the best estimate of a QTL position. Chromosome-wide significance thresholds were determined empirically from 10,000 permutations of marker genotypes.
Results—4 chromosomes contained putative QTL for OA of hip joints in dogs at the 5% chromosome-wide significance threshold: chromosomes 5, 18, 23, and 31.
Conclusions and Clinical Relevance—Osteoarthritis of canine hip joints is a complex disease to which many genes and environmental factors contribute. Identification of contributing QTL is a strategy to elucidate the genetic mechanisms that underlie this disease. Refinement of the putative QTL and subsequent candidate gene studies are needed to identify the genes involved in the disease process.
Contributor Notes
The authors thank Alma Williams, Liz Corey, and Margaret Vernier-Singer for technical assistance.
†Deceased.
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