Changes in the myocardial performance index during dobutamine administration in anesthetized cats

Yasutomo Hori Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan

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Masami Uechi Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252-8510, Japan.

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Atsuko Indou Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan

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Shigeki Yamano Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan

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Takashi Ebisawa Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan

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Kenji Teshima Department of Veterinary Surgery, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252-8510, Japan.

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Kazushi Asano Department of Veterinary Surgery, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252-8510, Japan.

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Abstract

Objective—To investigate the relationship between myocardial performance index (MPI; also known as the Tei index) and cardiac function in anesthetized cats administered dobutamine.

Animals—6 adult cats.

Procedures—Cats were anesthetized by administration of propofol (6 mg/kg, IV), and anesthesia was maintained by administration of isoflurane. Heart rate and systolic arterial pressure (SAP) were monitored. Stroke volume, cardiac output, and aortic blood flow (ABF) were measured by use of transesophageal ultrasonography. Left ventricular fractional shortening (LVFS), mitral E-wave velocity-to-A-wave velocity (E:A) ratio, and ejection time were measured by use of transthoracic echocardiography. Dobutamine was administrated via a cephalic vein at rates of 2.5, 5.0, and 10 μg/kg/min.

Results—Heart rate, SAP, cardiac output, and ABF increased with dobutamine administration, whereas stroke volume significantly decreased. The LVFS significantly increased, and the E:A ratio significantly decreased. Total isovolumic time and the MPI significantly decreased. The MPI was negatively correlated (r = −0.63) with LVFS. Conversely, the MPI was positively correlated with the E:A ratio (r = 0.47), stroke volume (r = 0.66), and total isovolumic time (r = 0.95). However, the MPI was not significantly correlated with heart rate, SAP, cardiac output, or ABF.

Conclusion and Clinical Relevance—Analysis suggested that the MPI provides a sensitive clinical assessment of cardiac response to medication in cats, which may be similar to the usefulness of the MPI reported in humans.

Abstract

Objective—To investigate the relationship between myocardial performance index (MPI; also known as the Tei index) and cardiac function in anesthetized cats administered dobutamine.

Animals—6 adult cats.

Procedures—Cats were anesthetized by administration of propofol (6 mg/kg, IV), and anesthesia was maintained by administration of isoflurane. Heart rate and systolic arterial pressure (SAP) were monitored. Stroke volume, cardiac output, and aortic blood flow (ABF) were measured by use of transesophageal ultrasonography. Left ventricular fractional shortening (LVFS), mitral E-wave velocity-to-A-wave velocity (E:A) ratio, and ejection time were measured by use of transthoracic echocardiography. Dobutamine was administrated via a cephalic vein at rates of 2.5, 5.0, and 10 μg/kg/min.

Results—Heart rate, SAP, cardiac output, and ABF increased with dobutamine administration, whereas stroke volume significantly decreased. The LVFS significantly increased, and the E:A ratio significantly decreased. Total isovolumic time and the MPI significantly decreased. The MPI was negatively correlated (r = −0.63) with LVFS. Conversely, the MPI was positively correlated with the E:A ratio (r = 0.47), stroke volume (r = 0.66), and total isovolumic time (r = 0.95). However, the MPI was not significantly correlated with heart rate, SAP, cardiac output, or ABF.

Conclusion and Clinical Relevance—Analysis suggested that the MPI provides a sensitive clinical assessment of cardiac response to medication in cats, which may be similar to the usefulness of the MPI reported in humans.

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