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1
Mateescu R, Dykes NL, Todhunter RJ, et al. QTL mapping using cross breed pedigrees: strategies for canine hip dysplasia. In: Ostrander EA, Giger U, Lindblad-Toh K, ed.The dog and its genome. Woodbury, NY: Cold Spring Harbor Laboratory Press, 2005;407–438.
-
2
Todhunter RL, Mateescu R, Lust G, et al. Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree. Mamm Genome 2005;16:720–730.
-
3
Chase K, Lawler DF, Adler FR, et al. Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris). Am J Med Genet 2004;124A:239–247.
-
4
Burton-Wurster N, Farese JP, Todhunter RJ, et al. Site-specific variation in femoral head cartilage composition in dogs at high and low risk for development of osteoarthritis: insights into cartilage degeneration. Osteoarthritis Cartilage 1999;7:486–497.
-
5
Kealy RD, Lawler DF, Monti KL, et al. Effects of dietary electrolyte balance on subluxation of the femoral head in growing dogs. Am J Vet Res 1993;54:555–562.
-
6
Kealy RD, Lawler DF, Ballam JM, et al. Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. J Am Vet Med Assoc 1997;210:222–225.
-
7
Kealy RD, Lawler DF, Ballam JM, et al. Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. J Am Vet Med Assoc 2000;217:1678–1680.
-
8
Kealy RD, Lawler DF, Ballam JM, et al. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 2002;220:1315–1320.
-
9
Kealy RD, Olsson SE, Monti KL, et al. Effects of limited food consumption on the incidence of hip dysplasia in growing dogs. J Am Vet Med Assoc 1992;201:857–863.
-
10
Popovitch CA, Smith GK, Gregor TP, et al. Comparison of susceptibility for hip dysplasia between Rottweilers and German Shepherd Dogs. J Am Vet Med Assoc 1995;206:648–650.
-
11
Smith GK, Popovitch CA, Gregor TP, et al. Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in dogs. J Am Vet Med Assoc 1995;206:642–647.
-
12
Chase K, Lawler DF, Carrier DR, et al. Genetic regulation of osteoarthritis: a QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris). Am J Med Genet A 2005;135:334–335.
-
13
Beighton P, Cilliers HJ, Ramesar R. Autosomal dominant (Beukes) premature degenerative osteoarthropathy of the hip joint unlinked to COL2A1. Am J Med Genet 1994;53:348–351.
-
14
Harris WH. Etiology of osteoarthritis of the hip. Clin Orthop 1986;213:20–33.
-
15
Hoaglund FT, Healy JH. Osteoarthrosis and congenital dysplasia of the hip in family members of children who have congenital dysplasia of the hip. J Bone Joint Surg Am 1990;72:1510–1518.
-
16
Weinstein SL. Developmental hip dysplasia and dislocation. In:Morrisy RT, Weinstein SL, ed.Lovell and Winter's pediatric orthopedics. Philadelphia: Lippincott-Raven, 1996;903–950.
-
17
Treble NJ, Jensen FO, Bankier A, et al. Development of the hip in multiple epiphyseal dysplasia. Natural history and susceptibility to premature osteoarthritis. J Bone Joint Surg Br 1990;72:1061–1064.
-
18
Spector TD, Cicuttini F, Baker J, et al. Genetic influences on osteoarthritis in women: a twin study. BMJ 1996;312:940–943.
-
19
Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 2000;133:635–646.
-
20
Peach CA, Carr AJ, Loughlin J. Recent advances in the genetic investigation of osteoarthritis. Trends Mol Med 2005;11:186–191.
-
21
Loughlin J. Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr Opin Rheumatol 2005;17:629–633.
-
22
Bliss S, Todhunter RJ, Quaas R, et al. Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds. Am J Vet Res 2002;63:1029–1035.
-
23
Todhunter RJ, Acland GM, Olivier M, et al. An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered 1999;90:83–92.
-
24
Todhunter RJ, Casella G, Bliss SP, et al. Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis. Am J Vet Res 2003;64:418–424.
-
25
Cardinet GH III, Guffy MM, Wallace LJ, et al. Canine hip dysplasia in German Shepherd Dog-Greyhound crossbreeds. J Am Vet Med Assoc 1983;182:393–395.
-
26
Lust G, Todhunter RJ, Erb HN, et al. Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs. J Am Vet Med Assoc 2001;219:1242–1246.
-
27
Olsewski JM, Lust G, Rendano VT, et al. Degenerative joint disease: multiple joint involvement in young and mature dogs. Am J Vet Res 1983;44:1300–1308.
-
28
Wolfinger RD, Tobias R, Sall J. Computing Gaussian likelihoods and their derivatives for general linear mixed models. SIAM J Sci Comput 1994;15:1294–1310.
-
29
Meuwissen TH, Goddard ME. Mapping multiple QTL using linkage disequilibrium and linkage analysis information and multitrait data. Genet Sel Evol 2004;36:261–279.
-
30
Kucerova J, Lund MS, Sorensen P, et al. Multitrait quantitative trait loci mapping for milk production traits in Danish Holstein cattle. J Dairy Sci 2006;89:2245–2256.
-
31
Todhunter RJ, Lust G. Canine hip dysplasia: pathogenesis. In:Slatter D, ed.Textbook of small animal surgery. Philadelphia: WB Saunders Co, 2003;2009–2019.
-
32
Fytili P, Giannatou E, Papanikolaou V, et al. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Clin Genet 2005;68:268–277.
-
33
Beling CG, Gustafsson PO, Kasstrom H. Metabolism of estradiol in Greyhounds and German Shepherd Dogs. An investigation with special reference to hip dysplasia. Acta Radiol Suppl 1975;344:109–120.
-
34
Czeizel A, Tusnady G, Vaczo G, et al. The mechanism of genetic predisposition in congenital dislocation of the hip. J Med Genet 1975;12:121–124.
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Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever–Greyhound pedigree
Abstract
Objective—To evaluate the quantitative inheritance of secondary hip joint osteoarthritis in a canine pedigree.
Animals—137 Labrador Retrievers, Greyhounds, and mixed-breed dogs.
Procedures—Necropsy scores ranging from 0 to 4 were obtained for each hip joint. Seven unaffected Greyhounds with normal hip joint conformation were also used for genetic modeling, but were not euthanized. Sixty-six male and 71 female dogs were allocated to 2 groups (≤ 12 months of age and > 12 months of age). Statistical models were developed to establish the inheritance pattern of hip joint osteoarthritis that developed secondary to hip dysplasia.
Results—62 dogs had evidence of osteoarthritis in a hip joint, and 75 had no evidence of osteoarthritis. After sex was adjusted for, the necropsy score was found to be inherited additively but without dominance. Each Labrador Retriever allele increased the necropsy score by 0.7 to 0.9 points, compared with the Greyhound allele, and male sex increased the necropsy score 0.74 over female sex. Approximately 10% of the variation in necropsy score was attributable to the litter of puppies' origin.
Conclusions and Clinical Relevance—Because secondary hip joint osteoarthritis is inherited additively, selection pressure could be applied to reduce its incidence. Similar statistical models can be used in linkage and association mapping to detect the genes in the underlying quantitative trait loci that contribute to hip joint osteoarthritis.
Contributor Notes
The authors thank Alma Williams, Margaret Vernier-Singer, Elizabeth Corey, Dr. Nathan Dykes, and Pam Gardner for assistance.
† Deceased
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