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-
1
Trotter EJ, De Lahunta A & Geary JC, et al. Caudal cervical vertebral malformation-malarticulation in Great Danes and Doberman Pinschers. J Am Vet Med Assoc 1976;168:917–930.
-
2
VanGundy TE. Disc-associated wobbler syndrome in the Doberman pinscher. Vet Clin North Am Small Anim Pract 1988;18:667–696.
-
3
Seim HB, Withrow SJ. Pathophysiology and diagnosis of caudal cervical spondylo-myelopathy with emphasis on the Doberman Pinscher. J Am Anim Hosp Assoc 1982;18:241–251.
-
4
McKee WM, Butterworth SJ, Scott HW. Management of cervical spondylopathy-associated intervertebral, disc protrusions using metal washers in 78 dogs. J Small Anim Pract 1999;40:465–472.
-
5
Mason TA. Cervical vertebral instability (wobbler syndrome) in the dog. Vet Rec 1979;104:142–145.
-
6
Lewis DG. Cervical spondylomyelopathy (‘wobbler” syndrome) in the dog: a study based on 224 cases. J Small Anim Pract 1989;30:657–665.
-
7
Sharp NJH, Wheeler SJ, Cofone M. Radiological evaluation of ‘wobbler” syndrome—caudal cervical spondylomyelopathy. J Small Anim Pract 1992;33:491–499.
-
8
Sharp NJH, Cofone M & Robertson ID, et al. Computed tomography in the evaluation of caudal cervical spondylomyelopathy of the Doberman Pinscher. Vet Radiol Ultrasound 1995;36:100–108.
-
9
Lipsitz D, Levitski RE & Chauvet AE, et al. Magnetic resonance imaging features of cervical stenotic myelopathy in 21 dogs. Vet Radiol Ultrasound 2001;42:20–27.
-
10
Batzdorf U, Flannigan BD. Surgical decompressive procedures for cervical spondylotic myelopathy. A study using magnetic resonance imaging. Spine 1991;16:123–127.
-
11
Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet 1985;1:1106–1107.
-
12
Maertens de Noordhout A, Remacle JM & Pepin JL, et al. Magnetic stimulation of the motor cortex in cervical spondylosis. Neurology 1991;41:75–80.
-
13
Nollet H, Van Ham L & Deprez P, et al. Transcranial magnetic stimulation: review of the technique, basic principles and applications. Vet J 2003;166:28–42.
-
14
Linden D, Berlit P. Magnetic motor evoked potentials (MEP) in diseases of the spinal cord. Acta Neurol Scand 1994;90:348–353.
-
15
Ravnborg M. The role of transcranial magnetic stimulation and motor evoked potentials in the investigation of central motor pathways in multiple sclerosis. Dan Med Bull 1996;43:448–462.
-
16
Fehlings MG, Tator CH, Linden RD. The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr Clin Neurophysiol 1989;74:241–259.
-
17
Kai Y, Owen JH & Allen BT, et al. Relationship between evoked potentials and clinical status in spinal cord ischemia. Spine 1995;20:291–296.
-
18
Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol 2003;2:145–156.
-
19
Bednarik J, Kadanka Z & Vohanka S, et al. The value of somatosensory and motor evoked potentials in pre-clinical spondylotic cervical cord compression. Eur Spine J 1998;7:493–500.
-
20
Tavy DL, Wagner GL & Keunen RW, et al. Transcranial magnetic stimulation in patients with cervical spondylotic myelopathy: clinical and radiological correlations. Muscle Nerve 1994;17:235–241.
-
21
Tavy DL, Franssen H & Keunen RW, et al. Motor and somatosensory evoked potentials in asymptomatic spondylotic cord compression. Muscle Nerve 1999;22:628–634.
-
22
Simo M, Szirmai I, Aranyi Z. Superior sensitivity of motor over somatosensory evoked potentials in the diagnosis of cervical spondylotic myelopathy. Eur J Neurol 2004;11:621–626.
-
23
Travlos A, Pant B, Eisen A. Transcranial magnetic stimulation for detection of preclinical cervical spondylotic myelopathy. Arch Phys Med Rehabil 1992;73:442–446.
-
24
Bednarik J, Kadanka Z & Dusek L, et al. Presymptomatic spondylotic cervical cord compression. Spine 2004;29:2260–2269.
-
25
Poma R, Parent JM & Holmberg DL, et al. Correlation between severity of clinical signs and motor evoked potentials after transcranial magnetic stimulation in large-breed dogs with cervical spinal cord disease. J Am Vet Med Assoc 2002;221:60–64.
-
26
Nollet H, Deprez P & Van Ham L, et al. The use of magnetic motor evoked potentials in horses with cervical spinal cord disease. Equine Vet J 2002;34:156–163.
-
27
Nollet H, Van Ham L & Verschooten F, et al. Use of magnetic motor-evoked potentials in horses with bilateral hind limb ataxia. Am J Vet Res 2003;64:1382–1386.
-
28
Nollet H, Deprez P & Van Ham L, et al. Transcranial magnetic stimulation: normal values of magnetic motor evoked potentials in 84 normal horses and influence of height, weight, age and sex. Equine Vet J 2004;36:51–57.
-
29
Di Lazzaro V, Restuccia D & Colosimo C, et al. The contribution of magnetic stimulation of the motor cortex to the diagnosis of cervical spondylotic myelopathy. Correlation of central motor conduction to distal and proximal upper limb muscles with clinical and MRI findings. Electroencephalogr Clin Neurophysiol 1992;85:311–320.
-
30
Lo YL, Chan LL & Lim W, et al. Systematic correlation of transcranial magnetic stimulation and magnetic resonance imaging in cervical spondylotic myelopathy. Spine 2004;29:1137–1145.
-
31
Lyu RK, Tang LM & Chen CJ, et al. The use of evoked potentials for clinical correlation and surgical outcome in cervical spondylotic myelopathy with intramedullary high signal intensity on MRI. J Neurol Neurosurg Psychiatry 2004;75:256–261.
-
32
da Costa RC, Parent JM & Partlow G, et al. Morphologic and morphometric magnetic resonance imaging features of Doberman Pinschers with and without clinical signs of cervical spondylomyelopathy. Am J Vet Res 2006;67:1601–1612.
-
33
Strain GM, Prescott-Mathews JS, Tedford BL. Motor potentials evoked by transcranial stimulation of the canine motor cortex. Progr Vet Neurol 1990;1:321–331.
-
34
Sylvestre AM, Cockshutt JR & Parent JM, et al. Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. Vet Surg 1993;22:5–10.
-
35
Kaneko K, Taguchi T & Morita H, et al. Mechanism of prolonged central motor conduction time in compressive cervical myelopathy. Clin Neurophysiol 2001;112:1035–1040.
-
36
Eisen A, Siejka S & Schulzer M, et al. Age-dependent decline in motor evoked potential (MEP) amplitude: with a comment on changes in Parkinson's disease. Electroencephalogr Clin Neurophysiol 1991;81:209–215.
-
37
Mazzocchio R, Rothwell JC & Day BL, et al. Effect of tonic voluntary activity on the excitability of human motor cortex. J Physiol 1994;474:261–267.
-
38
Takahashi M, Yamashita Y & Sakamoto Y, et al. Chronic cervical cord compression: clinical significance of increased signal intensity on MR images. Radiology 1989;173:219–224.
-
39
Ohshio I, Hatayama A & Kaneda K, et al. Correlation between histopathologic features and magnetic resonance images of spinal cord lesions. Spine 1993;18:1140–1149.
-
40
al-Mefty O, Harkey HL & Marawi I, et al. Experimental chronic compressive cervical myelopathy. J Neurosurg 1993;79:550–561.
-
41
Mehalic TF, Pezzuti RT, Applebaum BI. Magnetic resonance imaging and cervical spondylotic myelopathy. Neurosurgery 1990;26:217–226.
-
42
Teresi LM, Lufkin RB & Reicher MA, et al. Asymptomatic degenerative disk disease and spondylosis of the cervical spine: MR imaging. Radiology 1987;164:83–88.
-
43
Boden SD, McCowin PR & Davis DO, et al. Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 1990;72:1178–1184.
-
44
Matsumoto M, Fujimura Y & Suzuki N, et al. MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br 1998;80:19–24.
-
45
Kameyama O, Shibano K & Kawakita H, et al. Transcranial magnetic stimulation of the motor cortex in cervical spondylosis and spinal canal stenosis. Spine 1995;20:1004–1010.
-
46
Brunholzl C, Claus D. Central motor conduction time to upper and lower limbs in cervical cord lesions. Arch Neurol 1994;51:245–249.
-
47
de Noordhout AM, Myressiotis S & Delvaux V, et al. Motor and somatosensory evoked potentials in cervical spondylotic myelopathy. Electroencephalogr Clin Neurophysiol 1998;108:24–31.
-
48
Chu NS. Motor evoked potentials with magnetic stimulation: correlations with height. Electroencephalogr Clin Neurophysiol 1989;74:481–485.
-
49
Barker AT. The history and basic principles of magnetic nerve stimulation. In:Pascual-Leone A, Davey NJ, Rothwell J, et al, eds.Handbook of transcranial magnetic stimulation. London: Arnold, 2002;3–17.
-
50
Levy WJ, McCaffrey M & York DH, et al. Motor evoked potentials from transcranial stimulation of the motor cortex in cats. Neurosurgery 1984;15:214–227.
-
51
Kawai N, Nagao S. Origins and conducting pathways of motor evoked potentials elicited by transcranial magnetic stimulation in cats. Neurosurgery 1992;31:520–526.
-
52
Haghighi SS, Perez-Espejo MA & Oro JJ, et al. Origin of muscle action potentials evoked by transcranial magnetic stimulation in cats. Neurol Res 1995;17:469–473.
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Correlation of motor evoked potentials with magnetic resonance imaging and neurologic findings in Doberman Pinschers with and without signs of cervical spondylomyelopathy
Abstract
Objective—To establish the reference ranges for motor evoked potential (MEP) latency and amplitude in clinically normal Doberman Pinschers, compare the MEPs of Doberman Pinschers with and without clinical signs of cervical spondylomyelopathy (CSM; wobbler syndrome), and determine whether MEP data correlate with neurologic or magnetic resonance imaging (MRI) findings.
Animals—16 clinically normal and 16 CSM-affected Doberman Pinschers.
Procedures—Dogs were classified according to their neurologic deficits. After sedation with acepromazine and hydromorphone, transcranial magnetic MEPs were assessed in each dog; latencies and amplitudes were recorded from the extensor carpi radialis and cranial tibial muscles. Magnetic resonance imaging was performed to evaluate the presence and severity of spinal cord compression.
Results—Significant differences in cranial tibial muscle MEP latencies and amplitudes were detected between clinically normal and CSM-affected dogs. No differences in the extensor carpi radialis MEP were detected between groups. There was a significant correlation (r = 0.776) between the cranial tibial muscle MEP latencies and neurologic findings. Significant correlations were also found between MRI findings and the cranial tibial muscle MEP latencies (r = 0.757) and amplitudes (r = −0.453).
Conclusions and Clinical Relevance—Results provided a reference range for MEPs in clinically normal Doberman Pinschers and indicated that cranial tibial muscle MEP latencies correlated well with both MRI and neurologic findings. Because of the high correlation between cranial tibial muscle MEP data and neurologic and MRI findings, MEP assessment could be considered as a screening tool in the management of dogs with spinal cord disease.
Contributor Notes
Dr. Da Costa's present address is Universidade Federal do Paraná, Campus Palotina, Palotina, PR, 85950-000, Brazil.
This report represents a portion of a thesis submitted by the first author to the University of Guelph as partial fulfillment for the PhD degree.
Supported by the Pet Trust Foundation from the Ontario Veterinary College and the Doberman Foundation of America. Dr. da Costa was sponsored by the CNPq–National Scientific Research Council of Brazil.
Presented in part as an abstract at the 23rd American College of Veterinary Internal Medicine Forum, Baltimore, June 2005.
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