• 1

    Grummer RR. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J Anim Sci 1995;73:28202833.

  • 2

    Kelton DF, Lissemore KD, Martin RE. Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle. J Dairy Sci 1998;81:25022509.

    • Search Google Scholar
    • Export Citation
  • 3

    Fourichon C, Seegers H, Bareille N, et al.Effects of disease on milk production in the dairy cow: a review. Prev Vet Med 1999;41:135.

  • 4

    Van Maanen RW, Herbein JH, McGilliard AD, et al.Effects of monensin on in vivo rumen propionate production and blood glucose kinetics in cattle. J Nutr 1978;108:10021007.

    • Search Google Scholar
    • Export Citation
  • 5

    Richardson LF, Raun AP, Potter EL, et al.Effect of monensin on rumen fermentation in vitro and in vivo. J Anim Sci 1976;43:657664.

  • 6

    Duffield TF, Sandals D, Leslie KE, et al.Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows. J Dairy Sci 1998;81:28662873.

    • Search Google Scholar
    • Export Citation
  • 7

    Duffield TF, Leslie KE, Sandals D, et al.Effect of a monensin-controlled release capsule on cow health and reproductive performance. J Dairy Sci 1999;82:23772384.

    • Search Google Scholar
    • Export Citation
  • 8

    Stephenson KA, Lean IJ, Hyde ML, et al.Effects of monensin on the metabolism of periparturient dairy cows. J Dairy Sci 1997;80:830837.

  • 9

    Duffield TF, Sandals D, Leslie KE, et al.Effect of prepartum administration of monensin in a controlled-release capsule on postpartum energy indicators in lactating dairy cows. J Dairy Sci 1998;81:23542361.

    • Search Google Scholar
    • Export Citation
  • 10

    Duffield TF, Leslie KE, Sandals D, et al.Effect of prepartum administration of monensin in a controlled-release capsule on milk production and milk components in early lactation. J Dairy Sci 1999;82:272279.

    • Search Google Scholar
    • Export Citation
  • 11

    Green BL, McBride BW, Sandals D, et al.The impact of a monensin controlled-released capsule on subclinical ketosis in the transition dairy cows. J Dairy Sci 1999;82:333342.

    • Search Google Scholar
    • Export Citation
  • 12

    Mutsvangwa T, Walton JP, Plaizier JC, et al.Effects of a monensin controlled-release capsule or premix on attenuation of subacute ruminal acidosis in dairy cows. J Dairy Sci 2002;85:34543461.

    • Search Google Scholar
    • Export Citation
  • 13

    National Research Council. Nutrient requirements of dairy cattle. 7th revised ed. Washington, DC: National Academy Press, 2001.

  • 14

    Dohoo IR, Martin W, Stryhn H. Sample size. In: Dohoo IR, Martin W, Stryhn H, eds. Veterinary epidemiologic research. Charlottetown, PE, Canada: AVC Inc, 2003;2753.

    • Search Google Scholar
    • Export Citation
  • 15

    Ferguson JM, Galligan DT, Thomsen N. Principal descriptors of body condition score in Holstein cows. J Dairy Sci 1994;77:26952703.

  • 16

    Littell R, Milliken G, Stroup W, et al.SAS system for mixed models. Cary, NC: SAS Institute Inc, BBU Press, 1996.

  • 17

    Block E. Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever. J Dairy Sci 1984;67:29392948.

    • Search Google Scholar
    • Export Citation
  • 18

    Goff JP, Horst RL, Mueller FJ, et al.Addition of chloride to a prepartal diet high in cations increases 1,25-dihydroxyvitamin D response to hypocalcemia preventing milk fever. J Dairy Sci 1991;74:38633871.

    • Search Google Scholar
    • Export Citation
  • 19

    Block E. Manipulation of dietary cation-anion difference on nutritionally related production diseases, productivity, and metabolic responses of dairy cows. J Dairy Sci 1994;77:14371450.

    • Search Google Scholar
    • Export Citation
  • 20

    Vagnoni DB, Oetzel GR. Effects of dietary cation-anion difference on the acid-base status of dry cows. J Dairy Sci 1998;81:16431652.

  • 21

    Melendez P, Donovan A, Risco CA, et al.Effect of calcium-energy supplements on calving-related disorders, fertility and milk yield during the transition period in cows fed anionic diets. Theriogenology 2003;60:843854.

    • Search Google Scholar
    • Export Citation
  • 22

    Paisley LG, Mickelson WD, Anderson PB. Mechanisms and therapy for retained fetal membranes and uterine infections of cows: a review. Theriogenology 1986;25:353381.

    • Search Google Scholar
    • Export Citation
  • 23

    Correa MT, Erb H, Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. J Dairy Sci 1993;76:13051312.

  • 24

    Kimura K, Goff JP, Kehrli ME, et al.Decreased neutrophil function as a cause of retained placenta in dairy cattle. J Dairy Sci 2002;85:544550.

    • Search Google Scholar
    • Export Citation
  • 25

    Hoffman PC, Brehm NM, Price SG, et al.Effect of accelerated postpubertal growth and early calving on lactation performance of primiparous Holstein heifers. J Dairy Sci 1996;79:20242031.

    • Search Google Scholar
    • Export Citation
  • 26

    Chassagne M, Barnouin J, Chacornac JP. Risk factors for stillbirth in Holstein heifers under field conditions in France: a prospective survey. Theriogenology 1999;51:14771488.

    • Search Google Scholar
    • Export Citation
  • 27

    Drackley JK, Overton TR, Douglas GN. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. J Dairy Sci 2001;84(suppl E):E100E112.

    • Search Google Scholar
    • Export Citation
  • 28

    Clanton DC, England ME, Parrott JC. Effect of monensin on efficiency on production in beef cows. J Anim Sci 1981;53:873880.

  • 29

    Hixon DL, Fahey GC Jr, Kesler DJ, et al.Effects of creep feeding and monensin on reproductive performance and lactation of beef heifers. J Anim Sci 1982;55:467474.

    • Search Google Scholar
    • Export Citation
  • 30

    Baile CA, McLaughlin CL, Chalupa WV, et al.Effects of monensin fed to replacement dairy heifers during the growing and gestation period upon growth, reproduction, and subsequent lactation. J Dairy Sci 1982;65:19411944.

    • Search Google Scholar
    • Export Citation
  • 31

    Smith BI, Donovan GA, Risco C, et al.Comparison of various antibiotic treatments for cows diagnosed with toxic puerperal metritis. J Dairy Sci 1998;81:15551562.

    • Search Google Scholar
    • Export Citation
  • 32

    Suriyasathaporn W, Heuer C, Noordhuizen-Stassen EN, et al.Hyperketonemia and the impairment of udder defense: a review. Vet Res 2000;31:397412.

    • Search Google Scholar
    • Export Citation
  • 33

    Heuer C, Schukken YH, Jonker LJ, et al.Effect of monensin on blood ketone bodies, incidence and recurrence of disease and fertility in dairy cows. J Dairy Sci 2001;84:10851097.

    • Search Google Scholar
    • Export Citation
  • 34

    Carrier J, Stewart S, Godden S, et al.Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows. J Dairy Sci 2004;87:37253735.

    • Search Google Scholar
    • Export Citation
  • 35

    Duffield TF, LeBlanc S, Bagg R, et al.Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. J Dairy Sci 2003;86:11711176.

    • Search Google Scholar
    • Export Citation
  • 36

    Duffield T, Bagg R, DesCoteaux L, et al.Prepartum monensin for the reduction of energy associated disease in postpartum dairy cows. J Dairy Sci 2002;85:397405.

    • Search Google Scholar
    • Export Citation
  • 37

    Duffield T. Subclinical ketosis in lactating dairy cattle. Vet Clin North Am Food Anim Pract 2000;16:231253.

  • 38

    Radostits OM, Leslie KE, Fetrow J. Culling and genetic improvement programs for dairy herds. In: Radostits OM, Leslie KE, Fetrow J, eds. Herd health: food animal production medicine. 2nd ed. Philadelphia: WB Saunders Co, 1994;159182.

    • Search Google Scholar
    • Export Citation
  • 39

    Simpson RB, Chase CC, Hammond AC, et al.Average daily gain, blood metabolites, and body composition at first conception in Hereford, Senepol, and reciprocal crossbred heifers on two levels of winter nutrition and two summer grazing treatments. J Anim Sci 1998;76:396403.

    • Search Google Scholar
    • Export Citation
  • 40

    Meinert RA, Yang CMJ, Heinrichs AJ, et al.Effect of monensin on growth, reproductive performance, and estimated body composition in Holstein heifers. J Dairy Sci 1992;75:257261.

    • Search Google Scholar
    • Export Citation
  • 41

    Van der Werf JHJ, Jonker LJ, Oldenbroek JK. Effect of monensin on milk production by Holstein and Jersey cows. J Dairy Sci 1998;81:427433.

    • Search Google Scholar
    • Export Citation
  • 42

    Phipps RH, Wilkinson JID, Jonker LJ, et al.Effect of monensin on milk production of Holstein-Friesian dairy cows. J Dairy Sci 2000;83:27892794.

    • Search Google Scholar
    • Export Citation
  • 43

    Lean IJ, Curtis M, Dyson R, et al.Effects of sodium monensin on reproductive performance of dairy cattle. I. Effects on conception rates, calving to conception intervals, calving to heat and milk production in dairy cows. Aust Vet J 1994;71:273277.

    • Search Google Scholar
    • Export Citation
  • 44

    Hayes DP, Pfeiffer DU, Williamson NB. Effect of intraruminal monensin capsules on reproductive performance and milk production of dairy cows fed pasture. J Dairy Sci 1996;79:10001008.

    • Search Google Scholar
    • Export Citation
  • 45

    Abe N, Lean IJ, Rabiee A, et al.Effects of sodium monensin on reproductive performance of dairy cattle. II. Effects on metabolites in plasma, resumption of ovarian cyclicity and oestrus in lactating cows. Aust Vet J 1994;71:277282.

    • Search Google Scholar
    • Export Citation
  • 46

    Vallimont JE, Varga GA, Arieli A, et al.Effects of prepartum somatotropin and monensin on metabolism and production of periparturient Holstein dairy cows. J Dairy Sci 2001;84:26072621.

    • Search Google Scholar
    • Export Citation
  • 47

    Dechow CD, Rogers GW, Clay JS. Heritabilities and correlations among body condition scores, production traits, and reproductive performance. J Dairy Sci 2001;84:266275.

    • Search Google Scholar
    • Export Citation
  • 48

    Tallam SK, Duffield TF, Leslie KE, et al.Ovarian follicular activity in lactating Holstein cows supplemented with monensin. J Dairy Sci 2003;86:34983507.

    • Search Google Scholar
    • Export Citation
  • 49

    Beckett S, Lean I, Dyson R, et al.Effects of monensin on the reproduction, health and milk production of dairy cows. J Dairy Sci 1998;81:15631573.

    • Search Google Scholar
    • Export Citation
  • 50

    Domecq JJ, Skidmore AL, Lloyd JW, et al.Relationships between body condition scores and conception at first artificial insemination in a large dairy herd of high yielding Holstein cows. J Dairy Sci 1997;80:113120.

    • Search Google Scholar
    • Export Citation

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Effect of administration of a controlled-release monensin capsule on incidence of calving-related disorders, fertility, and milk yield in dairy cows

Pedro Melendez DVM, PhD1, Jesse P. Goff DVM, PhD2, Carlos A. Risco DVM3, Louis F. Archbald DVM, PhD4, Ramon C. Littell PhD5, and G. Arthur Donovan DVM, MSc6
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  • 1 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.
  • | 2 National Animal Disease Center, USDA, Ames, IA 50010.
  • | 3 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.
  • | 4 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.
  • | 5 Institute of Food and Agriculture Sciences, University of Florida, Gainesville, FL 32610-0136.
  • | 6 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136.

Abstract

Objective—To determine the effect of a controlled-release monensin capsule administered at cessation of lactation on incidence of calving-related disorders, fertility, and milk yield in dairy cows.

Animals—290 dairy cows treated with monensin and 290 untreated control cows.

Procedure—Treated cows received a capsule that released monensin at 335 mg/d for 95 days. Incidence of calving-related disorders; daily milk yield up to 20 days postpartum; test-day milk yield, fat, protein, and mature-equivalent 305-day milk production; and body condition score at calving were determined. Reproductive variables were conception rate at first service, pregnancy rate, and calving-to-conception interval.

Results—Cows treated with monensin were 2.1 times as likely to develop dystocia and 0.8 times as likely to develop metritis as control cows. For milk yield, there was an interaction of treatment ×time ×parity. In multiparous cows, monensin significantly improved milk yield at test days 4 and 7. In addition, monensin increased body condition score at calving.

Conclusions and Clinical Relevance—Despite increasing the likelihood of developing dystocia and metritis, administration of monensin improved the lactational performance of multiparous cows and may be a promising additive for use at the time of cessation of lactation.

Abstract

Objective—To determine the effect of a controlled-release monensin capsule administered at cessation of lactation on incidence of calving-related disorders, fertility, and milk yield in dairy cows.

Animals—290 dairy cows treated with monensin and 290 untreated control cows.

Procedure—Treated cows received a capsule that released monensin at 335 mg/d for 95 days. Incidence of calving-related disorders; daily milk yield up to 20 days postpartum; test-day milk yield, fat, protein, and mature-equivalent 305-day milk production; and body condition score at calving were determined. Reproductive variables were conception rate at first service, pregnancy rate, and calving-to-conception interval.

Results—Cows treated with monensin were 2.1 times as likely to develop dystocia and 0.8 times as likely to develop metritis as control cows. For milk yield, there was an interaction of treatment ×time ×parity. In multiparous cows, monensin significantly improved milk yield at test days 4 and 7. In addition, monensin increased body condition score at calving.

Conclusions and Clinical Relevance—Despite increasing the likelihood of developing dystocia and metritis, administration of monensin improved the lactational performance of multiparous cows and may be a promising additive for use at the time of cessation of lactation.

Contributor Notes

Supported by North Florida Holstein LLC.

Dr. Donovan.