Plasma concentrations of tumor necrosis factor-α in cats with congestive heart failure

Kathryn M. Meurs Department of Small Animal Medicine and Surgery and the Michael E. DeBakey Institute, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
Present address is Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

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Philip R. Fox Department of Medicine, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Matthew W. Miller Department of Small Animal Medicine and Surgery and the Michael E. DeBakey Institute, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843.

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Samir Kapadia Section of Cardiology, Department of Internal Medicine, College of Medicine, Baylor University, Houston, TX 77030.
Veterans' Administration Puget Sound Health Care System, 1660 S Columbian Way, Campus Box 358280, Seattle, WA 98108.
Present address is Veterans’ Administration Puget Sound Health Care System, 1660 S Columbian Way, Campus Box 358280, Seattle, WA 98108.

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Douglas L. Mann Section of Cardiology, Department of Internal Medicine, College of Medicine, Baylor University, Houston, TX 77030.

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Abstract

Objective—To determine whether plasma concentrations of tumor necrosis factor-α (TNF-α) are increased in cats with congestive heart failure (CHF) secondary to cardiomyopathy.

Animals—26 adult cats with CHF and cardiomyopathy and 9 healthy control cats.

Procedure—Plasma concentrations of TNF-α were measured in cats with CHF and cardiomyopathy. Tumor necrosis factor-α was measured by quantifying cytotoxic effects of TNF-α on L929 murine fibrosarcoma cells.

Results—Concentrations of TNF-α were increased (0.13 to 3.6 U/ml) in 10 of 26 cats with CHF but were undetectable in the other 16 cats with CHF and all control cats. In 20 of 26 cats with CHF, right-sided heart failure (RHF) was evident; TNF-α concentrations were increased in 9 of these 20 cats. The remaining 6 cats had left-sided heart failure (LHF); TNF-α concentrations were increased in only 1 of these cats. Age of cats with LHF (mean ± SD, 12.1 ± 6.2 years) was not significantly different from age of the cohort with RHF (10.5 ± 5.2 years). Body weight of cats with increased TNFα concentrations (5.4 ± 1.8 kg) was not significantly different from body weight of cats with CHF that did not have measurable concentrations of TNF-α (4.7 ± 1.6 kg).

Conclusionss and Clinical Relevance—Concentrations of TNF-α were increased in many cats with CHF. Cats with RHF were most likely to have increased TNF-α concentrations. Increased plasma concentrations of TNF-α in cats with CHF may offer insights into the pathophysiologic mechanisms of heart failure and provide targets for therapeutic interventions. (Am J Vet Res 2002;63:640–642)

Abstract

Objective—To determine whether plasma concentrations of tumor necrosis factor-α (TNF-α) are increased in cats with congestive heart failure (CHF) secondary to cardiomyopathy.

Animals—26 adult cats with CHF and cardiomyopathy and 9 healthy control cats.

Procedure—Plasma concentrations of TNF-α were measured in cats with CHF and cardiomyopathy. Tumor necrosis factor-α was measured by quantifying cytotoxic effects of TNF-α on L929 murine fibrosarcoma cells.

Results—Concentrations of TNF-α were increased (0.13 to 3.6 U/ml) in 10 of 26 cats with CHF but were undetectable in the other 16 cats with CHF and all control cats. In 20 of 26 cats with CHF, right-sided heart failure (RHF) was evident; TNF-α concentrations were increased in 9 of these 20 cats. The remaining 6 cats had left-sided heart failure (LHF); TNF-α concentrations were increased in only 1 of these cats. Age of cats with LHF (mean ± SD, 12.1 ± 6.2 years) was not significantly different from age of the cohort with RHF (10.5 ± 5.2 years). Body weight of cats with increased TNFα concentrations (5.4 ± 1.8 kg) was not significantly different from body weight of cats with CHF that did not have measurable concentrations of TNF-α (4.7 ± 1.6 kg).

Conclusionss and Clinical Relevance—Concentrations of TNF-α were increased in many cats with CHF. Cats with RHF were most likely to have increased TNF-α concentrations. Increased plasma concentrations of TNF-α in cats with CHF may offer insights into the pathophysiologic mechanisms of heart failure and provide targets for therapeutic interventions. (Am J Vet Res 2002;63:640–642)

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